Zobrazeno 1 - 10
of 2 794
pro vyhledávání: '"LINC"'
Autor:
Xuehuan Meng, Ye Zhu, Hao Tan, Baraa Daraqel, Ye Ming, Xiang Li, Guoyin Yang, Xinyi He, Jinlin Song, Leilei Zheng
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses. Yes-associated protein (YAP) is a rec
Externí odkaz:
https://doaj.org/article/ecf01d16ba894a89a98b1b90a05bf960
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 2, Pp 307-317 (2024)
Acute lymphoblastic leukemia (ALL) is the most prevailing cancer among children. Despite extensive studies, ALL etiology is still an unsolved puzzle. Long non-coding RNAs (lncRNAs) emerged as key mediators in cancer etiology. Several lncRNAs are dysr
Externí odkaz:
https://doaj.org/article/5ddc162f11ac4cdfa15a2ab5fbf5e2a3
Autor:
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emer
Externí odkaz:
https://doaj.org/article/8b88ef704fdc41188bda66bde4715d39
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract This review presents a comprehensive exploration of the pivotal role played by the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin proteins, in cellular mechanics and the pathogenesis of muscular
Externí odkaz:
https://doaj.org/article/ab69fc3ba7584311a9a0556a20f6eac9
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34075- (2024)
Dysregulation of long noncoding RNAs (lncRNAs), such as maternally expressed gene 3 (MEG3) and long intergenic noncoding RNA regulator of reprogramming (linc-ROR), plays a crucial role in colorectal cancer progression. We aimed to assess linc-ROR sil
Externí odkaz:
https://doaj.org/article/a97f52493d4a441795df78420b3d1cd0
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Long intergenic non-protein coding RNA, P53 induced transcript (LINC-PINT) exhibits different expression patterns in the majority of tumors, yet its relationship with cancer prognosis remains a subject of debate. This study aims to comprehen
Externí odkaz:
https://doaj.org/article/b0694dc7f94d40c394a701959641649d
Autor:
Theresa Paulus, Natalie Young, Emily Jessop, Carolin Berwanger, Christoph Stephan Clemen, Rolf Schröder, Rafal Ploski, Christian Hagel, Yorck Hellenbroich, Andreas Moser, Iakowos Karakesisoglou
Publikováno v:
Muscles, Vol 3, Iss 1, Pp 100-109 (2024)
SYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-e
Externí odkaz:
https://doaj.org/article/e71a6d2e4cbc420a8756d1031e1da6dd
Autor:
Ruisha Tu, Dunjing Zhong, Ping Li, Yongyu Li, Zhuang Chen, Feixiang Hu, Guihong Yuan, Zhaowei Chen, Shuyong Yu, Jian Song
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
Objectives Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with high incidence and mortality rates worldwide. This study aimed to investigate the correlation between LINC-PINT polymorphisms and ESCC risk in the Hainan Han population.Me
Externí odkaz:
https://doaj.org/article/e5ff0c46685c438298ce55e66691c45e
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechani
Externí odkaz:
https://doaj.org/article/69b0f1644f2b4919a922f43fa0f9bbef
Autor:
Joana T. Lima, Jorge G. Ferreira
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTCellular behavior is continuously influenced by mechanical forces. These forces span the cytoskeleton and reach the nucleus, where they trigger mechanotransduction pathways that regulate downstream biochemical events. Therefore, the nucleus h
Externí odkaz:
https://doaj.org/article/7958364dff7d47f7bedb23bc42c40d5c