Zobrazeno 1 - 10
of 234
pro vyhledávání: '"LIMK"'
Autor:
Jee-Yeon Ryu, Jianing Zhang, Selena-Rae Tirado, Sarajune Dagen, Kai U. Frerichs, Nirav J. Patel, M. Ali Aziz-Sultan, Alison Brown, Maximilian Rogers-Grazado, Sami S. Amr, Scott T. Weiss, Rose Du
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cerebral vasospasm (CVS) is an important contributor to delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH), leading to high morbidity and long-term disability. While several microRNAs (miRNAs) have been implicated
Externí odkaz:
https://doaj.org/article/822c9c34275b4b54b57c49427a657656
Akademický článek
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Autor:
Ji-Min Noh, Seung-Cheol Choi, Myeong-Hwa Song, Kyung Seob Kim, Seongmin Jun, Jae Hyoung Park, Ju Hyeon Kim, Kyoungmi Kim, Tae Hee Ko, Jong-Il Choi, Jeong-An Gim, Jong-Hoon Kim, Yongjun Jang, Yongdoo Park, Ji Eun Na, Im Joo Rhyu, Do-Sun Lim
Publikováno v:
Cells, Vol 12, Iss 16, p 2029 (2023)
The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease modeling. This study investigates the effects of cellular aggregate (CA) stem
Externí odkaz:
https://doaj.org/article/ef0364a8fad84c03a78242590f64ad95
Autor:
Qingfeng Yu, Chengjie Wu, Yeda Chen, Bingsheng Li, Ruixiao Wang, Ru Huang, Xuechun Li, Di Gu, Xiaolong Wang, Xiaolu Duan, Shujue Li, Yang Liu, Wenqi Wu, Martin Hennenberg, Guohua Zeng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1914-1930 (2021)
Overactive bladder (OAB) is the most bothersome symptom in lower urinary tract symptoms (LUTS). Current pharmacologic treatment aims to inhibit detrusor contraction; however, shows unsatisfied efficacy and high discontinuation rate. LIM kinases (LIMK
Externí odkaz:
https://doaj.org/article/45acd86a838d49659c591eec4b20cd77
Autor:
Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, Bojan Žunar, Michel Doudeau, Fabienne Godin, Hélène Bénédetti, Béatrice Vallée
Publikováno v:
Cells, Vol 12, Iss 5, p 805 (2023)
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtub
Externí odkaz:
https://doaj.org/article/b3b06cb558dc48d3866e0df980021655
Publikováno v:
Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 10, Pp 1579-1589 (2020)
Objective This study was conducted to investigate the roles of LIM kinases (LIMK1 and LIMK2) during porcine early embryo development. We checked the mRNA expression patterns and localization of LIMK1/2 to evaluate their characterization. We further e
Externí odkaz:
https://doaj.org/article/9f6ca07b416448aab388dea9ca1f08bb
Autor:
Daryl Ariawan, Carol Au, Esmeralda Paric, Thomas Fath, Yazi D. Ke, Michael Kassiou, Janet van Eersel, Lars M. Ittner
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting many cellular functio
Externí odkaz:
https://doaj.org/article/6f64097e86454ff89c0370f47fad2bdb
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zheng
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opp
Externí odkaz:
https://doaj.org/article/f5a93aee91754b5c87466dc7092a4a43
Autor:
Dong-Hun Lee, Ji Young Lee, Dong-Yong Hong, Eun Chae Lee, Sang-Won Park, Yu Na Jo, Yu Jin Park, Jae Young Cho, Yoo Jin Cho, Su Hyun Chae, Man Ryul Lee, Jae Sang Oh
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1348 (2022)
Dementia is a disease in which memory, thought, and behavior-related disorders progress gradually due to brain damage caused by injury or disease. It is mainly caused by Alzheimer’s disease or vascular dementia and several other risk factors, inclu
Externí odkaz:
https://doaj.org/article/bbe8326f874241cfaa0ba83010feec6e