Zobrazeno 1 - 10
of 94
pro vyhledávání: '"LGALS1"'
Autor:
Olga I. Urazova, Gleb V. Reyngardt, Yulia V. Kolobovnikova, Anna V. Kurnosenko, Vadim S. Poletika, Olga A. Vasil'yeva, Aleksandra V. Avgustinovich
Publikováno v:
Alʹmanah Kliničeskoj Mediciny, Vol 52, Iss 3, Pp 170-177 (2024)
Background: Galectin-1 plays an important role in the pathogenesis of colorectal cancer (CRC). The blood and tumoral levels of galectin-1 could be dependent on the polymorphism of the promotor region of LGALS1 gene. Aim: To analyze an association
Externí odkaz:
https://doaj.org/article/831cb4f5d01f40718a489e6114cadafe
Autor:
Fang Yang, Tong Li, Xiao-qian Zhang, Yi Gong, Hongwei Su, Junming Fan, Li Wang, Qiong-dan Hu, Rui-zhi Tan
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
The Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) has been clinically shown to effectively slow down the progression of chronic kidney disease (CKD) and has demonstrated significant anti-fibrosis effects in experimental CKD model.
Externí odkaz:
https://doaj.org/article/9e56bf64d5cb401c805219ca1a0bbc8b
Autor:
Qi Huang, Feiyu Li, Li Liu, Rui Xu, Tao Yang, Xiaoyun Ma, Hongmei Zhang, Yan Zhou, Yongxiang Shao, Qiaofeng Wang, Haifeng Xi, Yancai Ding
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Kidney renal clear cell carcinoma (KIRC), as a main type of malignant kidney cancers, has a poor prognosis. Epithelial-mesenchymal transformation (EMT) exerts indispensable role in tumor progression and metastasis, including in KIRC. Th
Externí odkaz:
https://doaj.org/article/6d8049b1895b4e2db9a553a9ce3b7334
Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma
Autor:
Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor response rates of curr
Externí odkaz:
https://doaj.org/article/976910c5b9a04a05a8d793a2fa75c789
Autor:
Sicheng Lu, Xiaoman Wei, Lihuiping Tao, Dan Dong, Wenlong Hu, Qinchang Zhang, Yuquan Tao, Chengtao Yu, Dongdong Sun, Haibo Cheng
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract tRNA-derived fragments (tRFs) are a class of small RNAs that occur when tRNAs are broken down by enzymes due to stress. Increasing reports have shown that tRFs are associated with multiple physiological and pathological processes, especially
Externí odkaz:
https://doaj.org/article/926cd5051b024c51b2d8fa106e778975
Autor:
Huanhuan Sun, Hong Zhang, Yan Yan, Yushi Li, Gang Che, Cuiling Zhou, Christophe Nicot, Haiqing Ma
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Numerous common oncogenic driver events have been confirmed in non-small cell lung cancer (NSCLC). Although targeted therapy has revolutionized NSCLC treatment, some patients still do not respond. NCAPG, also known as non-SMC cond
Externí odkaz:
https://doaj.org/article/cdc6084f0854431cbeacf8954891ce54
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Publikováno v:
Kidney & Blood Pressure Research, Pp 1-11 (2021)
Background: Acute kidney injury (AKI) is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying molecular targets related to the progression of AKI. Methods: A public database
Externí odkaz:
https://doaj.org/article/24f957f2b0ef4a6e8fc57d5183666039
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 9, p 275 (2022)
Background: The mortality rate from melanoma has been rising and hence new therapeutic approaches for this disease have received extensive attention, especially the search for novel therapeutic targets. The aim of this study was to find new targets f
Externí odkaz:
https://doaj.org/article/572b9ffe2d21441688edb3205986068a
Autor:
Ana Triguero-Martínez, Emilia Roy-Vallejo, Nuria Montes, Hortensia de la Fuente, Ana María Ortiz, Santos Castañeda, Isidoro González-Álvaro, Amalia Lamana
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7181 (2022)
Galectin 1 (Gal1) exerts immunomodulatory effects leading to therapeutic effects in autoimmune animal models. Patients with rheumatoid arthritis have been reported to show higher Gal1 serum levels than the healthy population. Our study aimed to find
Externí odkaz:
https://doaj.org/article/9ccc438d35df41d893e6da4c907f19fc