Zobrazeno 1 - 10
of 48
pro vyhledávání: '"LF Lacey"'
Autor:
Fridrun Podczeck, Abdul Basit, Peter J. Ell, Wendy A. Waddington, J. Michael Newton, LF Lacey
Publikováno v:
Pharmaceutical Research. 19:1368-1374
Purpose. To investigate the effect of co-administered polyethylene glycol 400 (PEG 400), a pharmaceutical excipient previously shown to accelerate small intestinal transit, on the absorption characteristics of ranitidine from the gastrointestinal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e00bbb6fa97ff4a6da47d66c8123659
https://doi.org/10.1023/a:1020315228237
https://doi.org/10.1023/a:1020315228237
Autor:
Abdul Basit, LF Lacey
Publikováno v:
International Journal of Pharmaceutics. 227:157-165
The aim of this study was to assess the in vitro stability of ranitidine to colonic bacteria by utilising a batch culture fermentation system to simulate the conditions of the colon. Three quantities of ranitidine, 100, 200 and 500 mg, in the form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8cbc33ca9ead80508b80da1f4b4cb4
https://doi.org/10.1016/s0378-5173(01)00794-3
https://doi.org/10.1016/s0378-5173(01)00794-3
Autor:
Abdul Basit, Peter J. Ell, Michael D. Short, Wendy A. Waddington, J. Michael Newton, LF Lacey
Publikováno v:
Pharmaceutical Research. 18:1146-1150
Purpose. To assess the effect of polyethylene glycol 400 (PEG 400), a pharmaceutical excipient frequently employed to enhance the solubility and bioavailability of poorly water-soluble drugs, on the gastrointestinal transit of liquid and pellet prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96a6ce7ad40467ffbe42b995237db6d
https://doi.org/10.1023/a:1010927026837
https://doi.org/10.1023/a:1010927026837
Publikováno v:
Pharmaceutical Development and Technology. 4:499-505
The present study was concerned with the feasibility of formulating ranitidine into pellets with a range of alternative excipients in place of microcrystalline cellulose (MCC). Eight ranitidine formulations employing two or more of the excipients lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3d03fa9083d3625673247dc528cd12
https://doi.org/10.1081/pdt-100101387
https://doi.org/10.1081/pdt-100101387
Publikováno v:
European Journal of Pharmaceutical Sciences. 6:259-263
The performance of different partial AUCs, including partial AUC from zero to t(max) of the reference formulation (AUC(r)) and partial AUC from zero to tmax of test or reference formulation, whichever occurs earliest (AUC(e), as indirect measures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bb165dad22ce8065cb89f5fe8b5c2f
https://doi.org/10.1016/s0928-0987(97)10023-9
https://doi.org/10.1016/s0928-0987(97)10023-9
Publikováno v:
Journal of Medical Economics. 1:247-261
SummaryThis study investigated the primary cost-drivers and determinants of the cost-effectiveness of antibacterial treatment of community-acquired pneumonia (CAP) in Germany. It assessed the health care costs and consequences related to treatment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4da2232ad731a410f3ef41b4342078
https://doi.org/10.3111/199801247261
https://doi.org/10.3111/199801247261
Autor:
Michael Hutchison, Bill Byrom, LF Lacey, Stuart Ellis, Oliver N. Keene, Kevin Gough, John McKellar
Publikováno v:
Scopus-Elsevier
There are a number of different approaches to the assessment of dose proportionality, but most of these are directed toward hypothesis testing. The analysis of dose proportionality studies, however, requires estimation rather than significance testin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52725c4950d7d4370ad696acfadf746
https://doi.org/10.1177/009286159502900324
https://doi.org/10.1177/009286159502900324
Publikováno v:
Drug Information Journal. 29:821-840
As indirect measures (metrics) of rate of drug absorption, Cmax is confounded by extent of drug absorption and tmax is a discrete variable, dependent on blood sampling frequency; therefore, there is a need for improved metrics of rate. Building upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10dfc48a99ec15085ae88bbd78ddb8dc
https://doi.org/10.1177/009286159502900305
https://doi.org/10.1177/009286159502900305
Publikováno v:
Pharmaceutical Research. 12:103-107
Bioequivalence assessment of extended release (ER) dosage forms is usually carried out at steady-state, using area under the curve (AUC) to evaluate extent of absorption and maximum concentration (Cmax) and % peak trough fluctuation ratio (%PTF) to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b300589628d0b567516c8e7b7e90961
https://doi.org/10.1023/a:1016246922519
https://doi.org/10.1023/a:1016246922519
Autor:
M.R. Jackson, Oliver N. Keene, R.J.N. Tanner, J.C.C Talbot, C.A. Endersby, W. Feniuk, Patrick P.A. Humphrey, V. Pfaffenrath, A.J. Pilgrim, N.S. Baber, LF Lacey, J.W. Lance, A.S. Marriott, E.G. Brown, R.N. Smith, M.L. Tucker, P.A. Fowler, M. Thomas
Publikováno v:
European Neurology. 31:300-305
Three oral doses of sumatriptan, 100, 200 and 300 mg, given as dispersible tablets, were compared in the acute treatment of migraine in a double-blind, placebo-controlled, parallel-group study of 1,13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb403998d99a6acef00f61d0ea6c82e
https://doi.org/10.1159/000116632
https://doi.org/10.1159/000116632