Zobrazeno 1 - 10
of 1 351
pro vyhledávání: '"LEVINE, HERBERT"'
Autor:
Kessler, David A., Levine, Herbert
The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In previous work,
Externí odkaz:
http://arxiv.org/abs/2311.00417
Publikováno v:
Soft Matter, 2023
We introduce an active version of the recently proposed finite Voronoi model of epithelial tissue. The resultant Active Finite Voronoi (AFV) model enables the study of both confluent and non-confluent geometries and transitions between them, in the p
Externí odkaz:
http://arxiv.org/abs/2303.08276
A phase field approach is proposed to model the chemotaxis of Dictyostelium discoideum. In this framework, motion is controlled by active forces as determined by the Meinhardt model of chemical dynamics which is used to simulate directional sensing d
Externí odkaz:
http://arxiv.org/abs/2302.14854
Autor:
Levine, Herbert, Goldman, Daniel I.
We offer our opinion on the benefits of integration of insights from active matter physics with principles of regulatory interactions and control to develop a field we term ``smart matter". This field can provide insight into important principles in
Externí odkaz:
http://arxiv.org/abs/2302.00234
Publikováno v:
Proc Natl Acad Sci USA, 119:e2210844119, 2022
The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulatory elements. These elements include chromatin remodelers, histone modi
Externí odkaz:
http://arxiv.org/abs/2209.05688
The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capability is achieved by the creation of a repertoire of cells each carrying
Externí odkaz:
http://arxiv.org/abs/2112.14879
Autor:
Jia, Dongya, Park, Jun Hyoung, Kaur, Harsimran, Jung, Kwang Hwa, Yang, Sukjin, Tripathi, Shubham, Galbraith, Madeline, Deng, Youyuan, Jolly, Mohit Kumar, Kaipparettu, Benny Abraham, Onuchic, Jose N., Levine, Herbert
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk be
Externí odkaz:
http://arxiv.org/abs/2011.13554
Epithelial cell clusters often move collectively on a substrate. Mechanical signals play a major role in organizing this behavior. There are a number of experimental observations in these systems which await a comprehensive explanation. These include
Externí odkaz:
http://arxiv.org/abs/2007.10488
Publikováno v:
Phys. Rev. E 102, 062420 (2020)
Quantifying the influence of microscopic details on the dynamics of development of the overall structure of a filamentous network is important in a number of biologically relevant contexts, but it is not obvious what order parameters can be used to a
Externí odkaz:
http://arxiv.org/abs/2006.06503
Eukaryotic cells are mechanically supported by a polymer network called the cytoskeleton, which consumes chemical energy to dynamically remodel its structure. Recent experiments in vivo have revealed that this remodeling occasionally happens through
Externí odkaz:
http://arxiv.org/abs/2006.01884