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Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A 4 hydrolase aminopeptidase inhibitors

Autor: Xiaoyong Xu, Dang Wu, Fan Zhang, Ping Ouyang, Jin Huang, Shuang Hou, Gao-Lei Wang

Publikováno v: Chinese Chemical Letters. 28:1044-1048

A series of novel 1,2,3-benzotriazin-4-one derivatives were designed, synthesized and their inhibitory activities against leukotriene A 4 hydrolase aminopeptidase in vitro were evaluated. Many compounds showed moderate to good activities at the conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a27b4ca741f4f5c64527e2f8502ae039
https://doi.org/10.1016/j.cclet.2016.12.014

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

Autor: Clare M. Lloyd, Angela Simpson, Tracy Hussell, Xin Xu, J. Edwin Blalock, Robert Niven, Lisa G. Gregory, Dhiren F. Patel, Samia Akthar, Chad Steele, Aleksander M. Grabiec, Simone A. Walker, Teresa Peiró, Jindong Li, Amit Gaggar, Amelia Shoemark, Robert J. Snelgrove, G Tavernier, Patricia L. Jackson, Jennifer Trevor

Publikováno v: Science Translational Medicine. 10

It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence the development and progression of chronic diseases. The enzyme leukotriene A4 hydrolase (LTA4H) mediates opposing proinflammatory and anti-inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f1ab4a2bd26dadfb0a9d085e66ee23
https://doi.org/10.1126/scitranslmed.aaq0693

The M1 family of vertebrate aminopeptidases: Role of evolutionarily conserved tyrosines in the enzymatic mechanism of aminopeptidase B

Autor: Julien Pernier, Sandrine Cadel, Cécile Darmon, Thierry Foulon, Guy Hervé

Publikováno v: Biochimie
Biochimie, Elsevier, 2015, 109, pp.67-77. ⟨10.1016/j.biochi.2014.12.009⟩
Biochimie, 2015, 109, pp.67-77. ⟨10.1016/j.biochi.2014.12.009⟩

International audience; Aminopeptidase B (Ap-B), a member of the M1 family of Zn2+-aminopeptidases, removes basic residues at the NH2-terminus of peptides and is involved in the in vivo proteolytic processing of miniglucagon and cholecystokinin-8. M1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09d49174c40b7e7ce7d37f371c2c918
https://doi.org/10.1016/j.biochi.2014.12.009

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