Zobrazeno 1 - 10
of 79
pro vyhledávání: '"LEOS KREN"'
Autor:
Klara Vejmelkova, Petra Pokorna, Kristyna Noskova, Anna Faustmannova, Klara Drabova, Zdenek Pavelka, Viera Bajciova, Martin Broz, Pavel Tinka, Marta Jezova, Hana Palova, Leos Kren, Dalibor Valik, Ondrej Slaby, Jaroslav Sterba
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023)
Abstract Rhabdoid tumors are aggressive tumors that may arise in the kidney, soft tissue, central nervous system, or other organs. They are defined by SMARCB1 (INI1) or SMARCA4 alterations. Often, very young children are affected, and the prognosis i
Externí odkaz:
https://doaj.org/article/07b78945d52d41e4a57738167cc779f3
Autor:
Jiri Sana, Petr Busek, Pavel Fadrus, Andrej Besse, Lenka Radova, Marek Vecera, Stefan Reguli, Lucie Stollinova Sromova, Marek Hilser, Radim Lipina, Radek Lakomy, Leos Kren, Martin Smrcka, Aleksi Sedo, Ondrej Slaby
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression a
Externí odkaz:
https://doaj.org/article/45af015b41e7425cbe979cb802a41555
Autor:
Jakub Neradil, Michal Kyr, Kristyna Polaskova, Leos Kren, Petra Macigova, Jan Skoda, Jaroslav Sterba, Renata Veselska
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The specific targeting of signal transduction by low-molecular-weight inhibitors or monoclonal antibodies represents a very promising personalized treatment strategy in pediatric oncology. In this study, we present the successful and clinically relev
Externí odkaz:
https://doaj.org/article/1c0111a9499a459bb2c611ad6acb8995
Autor:
Marek Vecera, Jiri Sana, Jan Oppelt, Boris Tichy, Kopkova Alena, Radim Lipina, Martin Smrcka, Radim Jancalek, Marketa Hermanova, Leos Kren, Ondrej Slaby
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211978 (2019)
Current progress in the field of next-generation transcriptome sequencing have contributed significantly to the study of various malignancies including glioblastoma multiforme (GBM). Differential sequencing of transcriptomes of patients and non-tumor
Externí odkaz:
https://doaj.org/article/569ca729b60648138682575f0af90093
Autor:
Milan Krticka, Ladislav Planka, Lucy Vojtova, Vladimir Nekuda, Premysl Stastny, Radek Sedlacek, Adam Brinek, Michaela Kavkova, Eduard Gopfert, Vera Hedvicakova, Michala Rampichova, Leos Kren, Kvetoslava Liskova, Daniel Ira, Jana Dorazilová, Tomas Suchy, Tomas Zikmund, Jozef Kaiser, David Stary, Martin Faldyna, Martin Trunec
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 733 (2021)
Many growth factors have been studied as additives accelerating lumbar fusion rates in different animal models. However, their low hydrolytic and thermal stability both in vitro and in vivo limits their workability and use. In the proposed work, a st
Externí odkaz:
https://doaj.org/article/37b9a6a0395848428e9c024d6063758d
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172552 (2017)
Medulloblastoma comprises four main subgroups (WNT, SHH, Group 3 and Group 4) originally defined by transcriptional profiling. In primary medulloblastoma tissues, these groups are thought to be distinguishable using the immunohistochemical detection
Externí odkaz:
https://doaj.org/article/e7481c1b28db40aab3b427b3170f65ce
Autor:
IVANA ROSKOVA, MAREK VECERA, LENKA RADOVA, KAROLINA TRACHTOVA, FRANTISEK SIEGL, MARKETA HERMANOVA, MICHAL HENDRYCH, LEOS KREN, VACLAV VYBIHAL, HANA VALEKOVA, PETRA KASPAROVA, IVANA KOLOUSKOVA, TOMAS KAZDA, ONDREJ SLABY, RADIM JANCALEK, JIRI SANA, MARTIN SMRCKA
Publikováno v:
Cancer Genomics Proteomics
CANCER GENOMICS & PROTEOMICS
CANCER GENOMICS & PROTEOMICS
Background/Aim: Brain metastases (BMs) are the most frequent intracranial tumors in adults and one of the greatest challenges for modern oncology. Most are derived from lung, breast, renal cell, and colorectal carcinomas and melanomas. Up to 14% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b37ec8f0990b3d6e18c0b700853e536
https://europepmc.org/articles/PMC9806667/
https://europepmc.org/articles/PMC9806667/
Autor:
Ulrich Jaeger, Marek Borsky, Jan Oppelt, Laura Z. Rassenti, Medhat Shehata, Václav Šeda, Thomas J. Kipps, Gabriela Pavlasova, Jennifer R. Brown, Daniel Filip, Kvetoslava Liskova, Šárka Pospíšilová, Eva Vojackova, Lenka Kostalova, Matthew S. Davids, Marek Mráz, Katerina Cerna, Sonali Sharma, Jiri Mayer, Andrea Janíková, Pedro Faria Zeni, Stacey M. Fernandes, Veronika Šandová, Laura Ondrisova, Michael Doubek, Leos Kren
Publikováno v:
Blood
B-cell receptor (BCR) signaling and T-cell interactions play a pivotal role in chronic lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use microRNAs (miRNAs) and their targets to modulate microenvironmental interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a337b68bb9ac88d669bfb33ed5069d
https://doi.org/10.1182/blood.2020005627
https://doi.org/10.1182/blood.2020005627
Autor:
Marek Vecera, Lenka Radova, Radim Lipina, Stefan Reguli, Martin Smrcka, Radim Jancalek, Michal Filip, Marketa Hermanova, Leos Kren, Dagmar Al Tukmachi, Tana Machackova, Petra Pokorna, Jiri Sana, Ondrej Slaby
Publikováno v:
Cancer Research. 83:3765-3765
Introduction: Glioblastoma (GBM) is the most frequent primary astrocytoma characterized by an aggressive and diffuse growth and a poor prognosis. The median survival of patients with GBM is only 12 to 16 months from diagnosis despite conventional the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71876566f59557c4792ae3eec7417b77
https://doi.org/10.1158/1538-7445.am2023-3765
https://doi.org/10.1158/1538-7445.am2023-3765
Autor:
Dagmar Al Tukmachi, Michaela Ruckova, Marek Vecera, Tana Machackova, Petra Pokorna, Marketa Hermanova, Michal Hendrych, Leos Kren, Ivana Roskova, Vaclav Vybihal, Hana Valekova, Radim Jancalek, Jiri Sana, Martin Smrcka, Ondrej Slaby
Publikováno v:
Cancer Research. 83:3758-3758
Brain metastases (BMs) comprise a heterogeneous group of the most frequent intracranial tumors in adults, most originating in lung, breast, renal cell, and colorectal carcinomas and melanomas. Despite the recent improvements in imaging methodology re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918d99fbb47ffeefb2670800a8157e79
https://doi.org/10.1158/1538-7445.am2023-3758
https://doi.org/10.1158/1538-7445.am2023-3758