Zobrazeno 1 - 10
of 6 047
pro vyhledávání: '"LEO E."'
Autor:
Albert Macaire C. Ong Lopez, Leo E. Tiu, Diana Collen Dimayuga, Oliver Allan C. Dampil, Erick S. Mendoza, Michael L. Villa, Andrea Marie Macabuag-Oliva
Publikováno v:
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background The diagnosis of primary aldosteronism (PA) is comprehensive, which includes case-detection testing, case confirmation followed by subtype classification. In certain instances, such as in the setting of spontaneous hypokalemia, su
Externí odkaz:
https://doaj.org/article/26a2613e641644faa723f4906fc91f8f
Autor:
Rodrigo W. Alves de Souza, Vanessa Voltarelli, David Gallo, Sidharth Shankar, Michael S. Tift, Mark Young, Edward Gomperts, Andrew Gomperts, Leo E. Otterbein
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Doxorubicin and other anthracyclines are crucial cancer treatment drugs. However, they are associated with significant cardiotoxicity, severely affecting patient care and limiting dosage and usage. Previous studies have shown that low carb
Externí odkaz:
https://doaj.org/article/c052d993bf7c44808e7eb723bc64da75
Autor:
Jianling Bi, Emily Witt, Megan K. McGovern, Arielle B. Cafi, Lauren L. Rosenstock, Anna B. Pearson, Timothy J. Brown, Thomas B. Karasic, Lucas C. Absler, Srija Machkanti, Hannah Boyce, David Gallo, Sarah L. Becker, Keiko Ishida, Joshua Jenkins, Alison Hayward, Alexandra Scheiflinger, Kellie L. Bodeker, Ritesh Kumar, Scott K. Shaw, Salma K. Jabbour, Vitor A. Lira, Michael D. Henry, Michael S. Tift, Leo E. Otterbein, Giovanni Traverso, James D. Byrne
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epi
Externí odkaz:
https://doaj.org/article/f858b9587aa7486a8b205a415ae94226
Autor:
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102965- (2023)
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost exclusively
Externí odkaz:
https://doaj.org/article/60a049bd7a644081bdd281cc51e743d3
Autor:
Xiangwei Shi, Kangyixin Sun, You Hu, Qinghan Wang, Guoyang Liao, Li Li, Pengjie Wen, Leo E. Wong, Fan Jia, Fuqiang Xu
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Neuroscience, gene therapy, and vaccine have all benefited from the increased use of viral vectors. Sindbis virus (SINV) is a notable candidate among these vectors. However, viral vectors commonly suffer from a loss of expression of the transgene, es
Externí odkaz:
https://doaj.org/article/17fa8cf5d6af4eb68b5111a313ba6efa
Autor:
Leo E. Akioyamen, MD, Anna Chu, MHSc, Jacques Genest, MD, Douglas S. Lee, MD, PhD, Husam Abdel-Qadir, MD, PhD, Cynthia A. Jackevicius, BScPhm, PharmD, MSc, Patrick R. Lawler, MD, MPH, Maneesh Sud, MD, Jacob A. Udell, MD, MPH, Harindra C. Wijeysundera, MD, PhD, Dennis T. Ko, MD, MSc
Publikováno v:
CJC Open, Vol 4, Iss 9, Pp 739-747 (2022)
Background: A simplified Canadian definition was recently developed to enable identification of individuals with familial hypercholesterolemia (FH) and severe hypercholesterolemia in the general population. Our objective was to use a modified version
Externí odkaz:
https://doaj.org/article/2a3efc5dac0641498154a894e87c2f3d
Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Autor:
Jianling Bi, Emily Witt, Vanessa A. Voltarelli, Vivian R. Feig, Veena Venkatachalam, Hannah Boyce, Megan McGovern, Wade R. Gutierrez, Jeffrey D. Rytlewski, Kate R. Bowman, Ashley C. Rhodes, Austin N. Cook, Benjamin N. Muller, Matthew G. Smith, Alexis Rebecca Ramos, Heena Panchal, Rebecca D. Dodd, Michael D. Henry, Adam Mailloux, Giovanni Traverso, Leo E. Otterbein, James D. Byrne
Publikováno v:
Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)
Abstract Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the response
Externí odkaz:
https://doaj.org/article/8033b7f9c53848e996896b38f139de6d
Publikováno v:
Journal of Glaciology, Vol 67, Pp 777-787 (2021)
We use seismic refraction data to investigate the firn structure across a suture zone on the Amery Ice Shelf, East Antarctica, and the possible role of glacier dynamics in firn evolution. In the downstream direction, the data reveal decreasing compre
Externí odkaz:
https://doaj.org/article/035ff35fdafa4be8acf5922e5ff11432
Autor:
Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent met
Externí odkaz:
https://doaj.org/article/72ed3803e97d40d080480ecd872ff483
Publikováno v:
Journal of Glaciology, Vol 66, Pp 166-174 (2020)
Ground-penetrating radar data acquired in the 2016/17 austral summer on Sørsdal Glacier, East Antarctica, provide evidence for meltwater lenses within porous surface ice that are conceptually similar to firn aquifers observed on the Greenland Ice Sh
Externí odkaz:
https://doaj.org/article/9443462b71bf4d56976acf970fd71409