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Distinct effects of apathy and dopamine on effort-based decision making in Parkinson’s disease

Autor: Le Heron, C, Plant, O, Manohar, S, Ang, Y, Jackson, M, Lennox, G, Hu, M, Husain, M

Publikováno v: Brain. 141(5)

Effort-based decision making is a cognitive process crucial to normal motivated behaviour. Apathy is a common and disabling complication of Parkinson’s disease, but its aetiology remains unclear. Intriguingly, the neural substrates associated with

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Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease

Autor: Muhammed K, sanjay manohar, Ben Yehuda M, Tt, Chong, Tofaris G, Lennox G, Bogdanovic M, Hu M, Husain M

Publikováno v: Europe PubMed Central

Apathy is a debilitating and under-recognized condition that has a significant impact in many neurodegenerative disorders. In Parkinson’s disease, it is now known to contribute to worse outcomes and a reduced quality of life for patients and carers

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