Zobrazeno 1 - 10
of 21
pro vyhledávání: '"LENA OSSWALD"'
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d9300956a84504938585998fec2dc2
https://doi.org/10.1158/1541-7786.c.6544992.v1
https://doi.org/10.1158/1541-7786.c.6544992.v1
Autor:
Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald
S1. KrasG12D recipient mice develop a myelodysplastic syndrome within the transferred WT hematopoietic system. S2. Gating strategy used for the isolation of bone marrow (BM) niche cells. S3. The frequency of BM niche cells is not affected in KrasG12D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b3296df9d02a5d90b9267cc3fde8e8
https://doi.org/10.1158/1541-7786.22526058
https://doi.org/10.1158/1541-7786.22526058
Autor:
KATRIN KOCH, LENA OSSWALD, ISABELLA MILLER, KRISCHAN BRAITSCH, KATHARINA GÖTZE, FLORIAN BASSERMANN, PETER HERHAUS, MAREIKE VERBEEK
Publikováno v:
Anticancer research. 42(11)
Cytomegalovirus (CMV) reactivation is one of the most clinically significant complications in allogeneic stem cell recipients and a frequent cause for transplantation related mortality. Letermovir is a newly available and recently approved drug for C
Autor:
Shaima’a Hamarsheh, Justus Duyster, Lukas Braun, Franziska M. Uhl, Sandra Duquesne, Geoffroy Andrieux, Robert Zeiser, Melanie Boerries, Annette Schmitt-Graeff, Lena Osswald, Christine Dierks, Tilman Brummer, Claudius Klein
Publikováno v:
Molecular Cancer Research. 19:1596-1608
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Lena, Osswald, Shaima'a, Hamarsheh, Franziska Maria, Uhl, Geoffroy, Andrieux, Claudius, Klein, Christine, Dierks, Sandra, Duquesne, Lukas M, Braun, Annette, Schmitt-Graeff, Justus, Duyster, Melanie, Boerries, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Molecular cancer research : MCR. 19(9)
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic
Autor:
Shaima'a, Hamarsheh, Lena, Osswald, Benedikt S, Saller, Susanne, Unger, Donatella, De Feo, Janaki Manoja, Vinnakota, Martina, Konantz, Franziska M, Uhl, Heiko, Becker, Michael, Lübbert, Khalid, Shoumariyeh, Christoph, Schürch, Geoffroy, Andrieux, Nils, Venhoff, Annette, Schmitt-Graeff, Sandra, Duquesne, Dietmar, Pfeifer, Matthew A, Cooper, Claudia, Lengerke, Melanie, Boerries, Justus, Duyster, Charlotte M, Niemeyer, Miriam, Erlacher, Bruce R, Blazar, Burkard, Becher, Olaf, Groß, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Donald Bunjes, Sebastian Halbach, Dietmar Pfeifer, Philipp Hemmati, Robert S. Negrin, Fabio Ciceri, Jean-Yves Cahn, Markus Ditschkowski, Pavan Reddy, Kathrin Hanke, Daniela Dörfel, Susan Klaeger, Jürgen Finke, Zehan Hu, Gabriele Ihorst, Gérard Socié, Sanaz Taromi, Andreas Hochhaus, Glen A Kennedy, Omid Shah, Andreas Neubauer, Robert Thimme, Michael Schultheiss, Sabine Spath, Dietrich W. Beelen, Sandra Duquesne, Arnim Weber, Geoffrey R. Hill, Ronjon Chakraverty, Jürgen Kuball, Guido Kobbe, Nikolas von Bubnoff, Andrea S. Henden, Betul Oran, Burkhard Becher, Bernhard Kuster, Christoph Rummelt, Lena Osswald, Hartmut Bertz, Wolfgang Bethge, Eva-Maria Wagner, Arnon Nagler, Eliana Ruggiero, Saar Gill, Miguel Waterhouse, Andreas Mackensen, Dominik Bettinger, Francis Baumgartner, Florian Kuchenbauer, Anita Sarma, Takanori Teshima, Erika L. Pearce, Antonia M.S. Müller, Kathleen Stabla, John M. Magenau, Evelyn Ullrich, Nicolaus Kröger, Georg Häcker, Simone Thomas, Myriam Labopin, Ghulam J. Mufti, Jan E. Ehlert, Lutz P. Müller, Marie Follo, Dominik Wolf, Tony Andreas Müller, Michael Lübbert, Jacqueline Schnell, Christof Scheid, Takeshi Kondo, Donal P. McLornan, Thomas Pabst, Konrad Wilhelm, Chiara Bonini, Wolf Rösler, Simon Richardson, Cordula A. Jilg, Andrea Schmidts, Luca Vago, Joseph H. Antin, Annette Schmitt-Graeff, Yakup Tanriver, Michael A. Caligiuri, Wolfgang Herr, Kai-Li Yan, Lukas Braun, Daniel J. Weisdorf, Katayoun Rezvani, Giang Lam Vuong, Tilman Brummer, Stephan Meckel, Ralph Wäsch, Geoffroy Andrieux, Soroush Doostkam, Hauke Busch, Dennis Dong Hwan Kim, Sabine Gerull, Bruce R. Blazar, Robert Zeiser, Merav Bar, Flore Sicre-de-Fontbrune, Daniel Feger, Melanie Börries, Wolfgang Melchinger, Petya Apostolova, C. Leiber, Udo Holtick, Walter J.F.M. van der Velden, Renate Arnold, Rainer Claus, Justus Duyster, Nimitha R. Mathew, David O’Sullivan, Alexandros Spyridonidis, S K Metzelder, Thomas Schroeder, Jörg Halter, Johanna Haag, Friedrich Stölzel, Christoph Schmid, Anna Lena Illert, Claudia Lengerke, Björn Hackanson, Joern Dengjel, Francis Ayuk, Rainer Ordemann, Sonia Tugues, Marco Prinz, Inken Hilgendorf, Andreas Burchert
Publikováno v:
Nature Medicine
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Contains fulltext : 190745.pdf (Publisher’s version ) (Closed access) Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogenei
Autor:
Tilman Brummer, Shaima’a Hamarsheh, Olaf Groß, Claudia Lengerke, Oliver Gorka, Lena Osswald, Justus Duyster, Melanie Börries, Miriam Erlacher, Robert Zeiser
Publikováno v:
Blood. 132:2618-2618
Oncogenic Ras mutations occur frequently in myelodysplastic (MDS) and myeloproliferative syndromes (MPN). It was unclear if besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation related effect of KRAS contributes