Zobrazeno 1 - 10 of 336 pro vyhledávání: '"LEC rat"'
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Role of p38 Mapk in Development of Acute Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model of Human Wilson's Disease
Autor: Masanobu Hayashi, Yoshitaka Imaizumi, Saori Meguro, Hiroshi Sakai, Daiji Endoh, Shingo Kadowaki
Publikováno v: The Journal of Veterinary Medical Science
The Long-Evans Cinnamon (LEC) rat, an animal model of human Wilson’s disease, spontaneously develops fulminant hepatitis associated with severe jaundice at about 4 months of age. In this study, we examined the changes in gene expression during prog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0265d911fdd3557e1648e58bd1075d
http://hdl.handle.net/10659/3810
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3
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats
Autor: Koji Yasutomo, Shin-ichi Tsukumo, Kaichun Wei, Hiroyuki Kose, Tohru Sakai, Kozo Matsumoto, Takahisa Yamada
Publikováno v: Genomics. 89(6):673-677
The Long-Evans Cinnamon (LEC) rat has a spontaneous mutation, T helper immunodeficiency (thid), which causes a markedly reduced CD4(+) thymocyte population. Here we positionally clone the locus and identify a deletion in the gene encoding a receptor-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb532a74091ea636546932dfbdc69a70
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Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride
Autor: Mitsuo Shimada, Takamasa Ohnishi, Keisuke Izumi, Nobuo Satake, Toshihiro Otsuka, Seiki Tashiro, Takako Gotohda, Itsuo Tokunaga, Shinya Kaneda, Yoshiharu Takiguchi, Kaneshige Ipposhi
Publikováno v: The journal of medical investigation : JMI. 53(1-2):81-86
Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson's disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc7fba02a581f1d46bb060f2726cd02
http://repo.lib.tokushima-u.ac.jp/110791
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Identification of the 'missing domain' of the rat copper-transporting ATPase, atp7b: insight into the structural and metal binding characteristics of its N-terminal copper-binding domain
Autor: Suree Narindrasorasak, Mike J. Tsay, Negah Fatemi, John R. Forbes, Bibudhendra Sarkar
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1688(1):78-85
Wilson disease is an autosomal disorder of copper transport caused by mutations in the ATP7B gene encoding a copper-transporting P-type ATPase. The Long Evans Cinnamon (LEC) rat is an established animal model for Wilson disease. We have used structur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c622d1797f2141d0004ce992c5a99f46
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Role ofAtp7bGene in Spontaneous andN-Diethylnitrosamine-induced Carcinogenesis in a New Congenic Strain, WKAH.C-Atp7bRats
Autor: Kozo Matsumoto, Takahisa Yamada, Zhongxian Jiao, Toshihiro Otsuka, Shinya Kaneda, Keisuke Izumi, Yasuo Suzuki, Takanori Minami
Publikováno v: Japanese Journal of Cancer Research : Gann
To examine whether Long‐Evans Cinnamon (LEC) rats, a mutant rat model of Wilson's disease, have a susceptibility gene(s) to hepatocarcinogenesis in addition to the causative gene, Atp7b, we established a new congenic strain, WKAH.C‐Atp7b rats, in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67c8fb133378cc1c0247503c9250263
https://doi.org/10.1111/j.1349-7006.2001.tb01170.x
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Low Susceptibility of Long‐Evans Cinnamon Rats to N‐Butyl‐N‐(4‐hydroxybutyl)‐nitrosamine‐induced Urinary Bladder Carcinogenesis and Inhibitory Effect of Urinary Copper
Autor: Hisanori Uehara, Takamasa Yamada, Yoshifumi Chone, Keisuke Kitaura, Takanori Minami, Yoshimi Bando, Zhongxian Jiao, Yoshinari Ohnishi, Masataka Mochizuki, Keisuke Izumi, Yasuo Suzuki, Takemi Kinouchi
Publikováno v: Japanese Journal of Cancer Research : Gann
We studied the susceptibilities to N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine (BBN)‐induced urinary bladder carcinogenesis of male Long‐Evans Cinnamon (LEC), F344 and Long‐Evans Agouti (LEA) rats. Male rats (n=21) were given 0.1% BBN in thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa562c74f17b53bd86d2cbe496ca0aca
http://europepmc.org/articles/PMC5926224
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Localization of the Wilson's disease protein in human liver
Publikováno v: Gastroenterology. 117(6):1380-1385
Background & Aims: Wilson's disease is an autosomal-recessive disorder of copper metabolism that results from the absence or dysfunction of a copper-transporting P-type adenosine triphosphatase that leads to impaired biliary copper excretion and dist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::ba591f705430af7f5dc719d510a8165c
https://research.rug.nl/en/publications/21ce96ab-7ce0-4fc7-870d-f8b556cbe42b
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