Zobrazeno 1 - 10
of 36
pro vyhledávání: '"LEB Souza"'
Autor:
CB Machado, KS Esteves, SCG Lima, IP Furtado, M Brandão, FMCP Pessoa, BMD Nogueira, MEA Moraes, LEB Souza, CFA Moreira-Nunes
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S352-S353 (2024)
Background: Adult patients afflicted with Acute Lymphoblastic Leukemia (ALL) still represent a subset of poor prognosis, with a 5-year overall survival of around 46%. The development of new therapeutic approaches is of utmost importance to the oncolo
Externí odkaz:
https://doaj.org/article/42915fb1324f4697afdd82448b719c7a
Autor:
CB Machado, WAS Ferreira, FMCP Pessoa, FAR Mell-Júnior, AD Seabra, RM Ribeiro, MO Morae-Filho, MEA Moraes, LEB Souza, CFA Moreir-Nunes
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S229-S230 (2023)
Objective: BCR-ABL1 p190 translocation represents a worse prognosis for acute lymphoblastic leukemia (ALL) patients, and development of new therapeutic approaches is of utmost importance to the oncologic routine. This study aims to evaluate the cytot
Externí odkaz:
https://doaj.org/article/6bd8ecfc432f4b328f856fe94e3f3b0d
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S279- (2023)
Objectives: Acute Myeloid Leukemia (AML) is a complex and heterogeneous disease characterized by the blockage of blood cell maturation, leading to uncontrolled proliferation of immature malignant cells. Based on cytogenetic characteristics, AML can b
Externí odkaz:
https://doaj.org/article/f1e79d0a0f294b22971d32e759f365fb
Autor:
RM Silveira, IP Furtado, DMC Fantacini, R Rossetti, AUQ Ferreira, L Tsyrenov, H Shiku, DT Covas, LEB Souza
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S418- (2023)
Introdução/Objetivo: Os receptores de antígenos quiméricos (CARs) convencionais reconhecem apenas antígenos de superfície celular em sua conformação nativa. Isto limita a aplicação da terapia, já que a maioria dos antígenos associados a t
Externí odkaz:
https://doaj.org/article/88f1d72689744b1fb56e4e9bbd160bc5
Autor:
SCG Lima, R Rossetti, AU Quadros, KS Esteves, IP Furtado, DMC Fantacini, RM Silveira, DT Covas, LEB Souza
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S536-S537 (2023)
Allogeneic Chimeric Antigen Receptor (CAR) T cell therapy represents a promising approach to overcome the accessibility limitations of conventional autologous treatment. Some advantages of such allogeneic therapy include the availability of an off-th
Externí odkaz:
https://doaj.org/article/283d458406fb404c973eb783bd75ac37
Autor:
IP Furtado, RM Silveira, R Rossetti, DMC Fantacini, SCG Lima, L Tsyrenov, H Shiku, LEB Souza, DT Covas
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S539- (2023)
The treatment of solid tumors with CAR-T cells is challenging due to the complex tumor microenvironment that impairs infiltration and persistence of injected cells. Thus, enhancing persistence and resistance to exhaustion of CAR-T cells is desirable
Externí odkaz:
https://doaj.org/article/4338a707b7564228a987ea7f9526f459
Autor:
R Rossetti, SCG Lima, DMC Fantacini, JV Carvalho, IP Furtado, RM Silveira, L Tsyrenov, H Shiku, LEB Souza, DT Covas
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S541-S542 (2023)
Despite the remarkable success in the use of T cells expressing Chimeric Antigen Receptors (CAR) for hematologic malignances, their application to solid tumors, which represents the majority of neoplasms, remains challenging. However, T lymphocytes e
Externí odkaz:
https://doaj.org/article/6947851cc4da4c29b391223624c59dab
Autor:
LLS Figueiredo, LEB Souza, MD Orellana, DT Covas, F Lichtenstein, V Siciliano, KJ Abraham, R Weiss, SL Gerson, AM Fontes
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S839- (2023)
Background: Gaucher disease (GD) is a rare lysosomal storage disease caused by pathogenic variants in the glucocerebrosidase gene (GBA1) resulting in a markedly decreased activity of the lysosomal enzyme b-glucocerebrosidase (GCase). Enzyme replaceme
Externí odkaz:
https://doaj.org/article/2168dd73a0cf489984d1f680d65a4f60
Autor:
DMC Fantacini, SCG Lima, R Rossetti, IP Furtado, RM Silveira, L Tsyrenov, H Shiku, DT Covas, LEB Souza
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S552- (2023)
Adoptive therapy using Chimeric Antigen Receptor T-cell (CAR-T) technology has emerged as a groundbreaking immunotherapeutic approach for treating various hematological malignancies. Among the diverse CAR-T targets, CD19, a B-cell surface marker, has
Externí odkaz:
https://doaj.org/article/2725cbb49d1f4b6ab45d030b16c7529e
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S248- (2021)
Introduction: The emerging of chimeric antigen receptor (CAR) T cell therapy has shown promising results leading to the FDA approval of five CAR T cell products by now. Anti CD19 CAR T cells have shown >80% complete remission rates in acute B cell le
Externí odkaz:
https://doaj.org/article/b8d4cad85859438cbed65b9f6f3f73cf