Zobrazeno 1 - 10 of 29 pro vyhledávání: '"LDLR, LDL receptor"'
1
Animal Models of Neointimal Hyperplasia and Restenosis
Autor: Melanie A. Kimm, Vanessa Franziska Schmidt, Max L.A. Ebert, Lena Pfaff, Anne von Thaden, Moritz Wildgruber
Publikováno v: JACC: Basic to Translational Science
Central Illustration
Highlights • Neointimal hyperplasia is the major factor contributing to restenosis after angioplasty procedures. • Multiple animal models exist to study basic and translational aspects of restenosis formation. • Animal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88165634a122d3faf899cdcac81ed099
https://doi.org/10.1016/j.jacbts.2021.06.006
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2
Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies
Autor: Liang Han, Chen Jiang
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs, resulting in ineffective drug therapy of brain diseases. However, during the onset and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5b
http://www.sciencedirect.com/science/article/pii/S2211383520308522
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3
The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer
Autor: Nabil G. Seidah
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)
In 2003 the sequences of mammalian PCSK9 were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a zymogen (proPCSK9) that undergoes autocatalytic cleavage in the endoplasmic reticulum. Distinct from the other pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b1dcccbf273c1836a23142dd023f3
http://europepmc.org/articles/PMC8551645
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4
Novel Presentation of Homozygous Familial Hypercholesterolemia With Homozygous Variants in Both LDLR and APOB Genes
Autor: Emily J. Brown, Karan Kapoor, Kathleen Byrne, Seth S. Martin, Robert Derenbecker, Parvez M. Lokhandwala, Thorsten M Leucker, Steven R. Jones
Publikováno v: JACC: Case Reports, Vol 1, Iss 3, Pp 346-349 (2019)
JACC Case Reports
This case report describes a 50-year-old-woman from Southeast Asia with extensive atherosclerotic cardiovascular disease, found to have homozygous familial hypercholesterolemia caused by variants of uncertain significance in both the APOB and LDLR ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66ba42484897ad30189d361a7824cce
http://www.sciencedirect.com/science/article/pii/S2666084919302608
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5
Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4
Autor: Yishi Shen, Shucun Qin, Bingxiang Wang, Yongfang Zhao, Lei Zhai, Boyan Liu, Xiaole Chang, Adekunle Alabi, Shijun Deng, Maggie Wang, Hong-mei Gu, Da-Wei Zhang, Xiao-dan Xia, Guiqing Wang, Sijie Xing
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100091-(2021)
Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDLR degradation, increasing plasma LDL-C levels. Circulating PCSK9
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ace96902105c8bd0f6e5ca427b95574
http://europepmc.org/articles/PMC8261665
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6
Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background
Autor: Juro Sakai, Masashi Muramatsu, Toshiya Tanaka, Suguru Nakagawa, Sandra Ryeom, Tatsuhiko Kodama, Yuri Miyamura, Takashi Minami, Hiroyuki Aburatani, Tsuyoshi Osawa
Publikováno v: The Journal of Biological Chemistry
Down syndrome critical region (DSCR)-1 functions as a feedback modulator for calcineurin-nuclear factor for activated T cell (NFAT) signals, which are crucial for cell proliferation and inflammation. Stable expression of DSCR-1 inhibits pathological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e97026d95511588f7efa815e569ed7
http://europepmc.org/articles/PMC8142255
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7
Animal Models of Neointimal Hyperplasia and Restenosis: Species-Specific Differences and Implications for Translational Research
Autor: Ebert, Max L A, Schmidt, Vanessa F, Pfaff, Lena, von Thaden, Anne, Kimm, Melanie A, Wildgruber, Moritz
Publikováno v: JACC Basic to translational science 6(11), 900-917 (2021). doi:10.1016/j.jacbts.2021.06.006
The process of restenosis is based on the interplay of various mechanical and biological processes triggered by angioplasty-induced vascular trauma. Early arterial recoil, negative vascular remodeling, and neointimal formation therefore limit the lon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10678::dc85333e28de216e8209e7dde8278277
https://pub.dzne.de/record/163653
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8
Lipoprotein Metabolism in Familial Hypercholesterolemia
Autor: Dirk J. Blom, César Martín, Kévin Chemello, Gilles Lambert, Antonio Gallo, Javier García-Nafría
Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Journal of Lipid Research
Journal of Lipid Research, 2021, pp.100062. ⟨10.1016/j.jlr.2021.100062⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100062-(2021)
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2021, pp.100062. ⟨10.1016/j.jlr.2021.100062⟩
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Familial hypercholesterolemia (FH) is one of the most common genetic disorders in humans. It is an extremely atherogenic metabolic disorder characterized by lifelong elevations of circulating LDL-C levels often leading to premature cardiovascular eve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44447337b377c6d9f787e9f7ad596c58
http://hdl.handle.net/10810/51139
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9
Existing and emerging therapies for the treatment of familial hypercholesterolemia
Autor: Robert S. Rosenson
Publikováno v: Journal of Lipid Research, Vol 62, Iss, Pp 100060-(2021)
Journal of Lipid Research
Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease. Combinations of cholesterol lower
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ba8f82481a6523dc9ab4793ce9944e
http://www.sciencedirect.com/science/article/pii/S0022227521000420
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10
Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis
Autor: Kaylin M. McMahon, Adam Yuh Lin, Reem Karmali, Andrea E. Calvert, Shuo Yang, C. Shad Thaxton, Jonathan Moreira, Jonathan S. Rink, Amir Behdad, Tim Taxter, Amy Chadburn, Leo I. Gordon
Publikováno v: The Journal of Biological Chemistry
Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet their metabolic requirements. In some malignant cells, de novo cholesterol synthesis genes are transcriptionally silent or mutated, meaning that cholesterol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cb836b9ce6f454dd5dbd3c4704784a
http://europepmc.org/articles/PMC7949030
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