Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Autor: Anouk M. La Rose, Anouk G. Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, Kishore A. Krishnamurthy, Mirjam H. Koster, Niels J. Kloosterhuis, Marieke Smit, Rick Havinga, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer, Marit Westerterp

Publikováno v: Molecular genetics and metabolism reports, 31:100872. ELSEVIER SCIENCE BV
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Elsevier, 2022, 31, pp.100872. ⟨10.1016/j.ymgmr.2022.100872⟩
Molecular genetics and metabolism reports, 31. ELSEVIER SCIENCE BV

International audience; Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06623b936939b70b1a20d74655821967
https://doi.org/10.1016/j.ymgmr.2022.100872

Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice

Autor: Trudy M. Forte, Ganesamoorthy Subbanagounder, Judith A. Berliner, Patricia J. Blanche, Anne O. Clermont, Zhen Jia, Michael N. Oda, Ronald M. Krauss, John K. Bielicki

Publikováno v: Journal of Lipid Research, Vol 43, Iss 3, Pp 477-485 (2002)

We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)−/− and LDL receptor (LDLr)�

Externí odkaz: https://doaj.org/article/10604708fe684811aedc26965aec9bc7

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Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr −/− mice versus hamsters[S]

Autor: Andreas Staempfli, Denise Blum, Christophe Gardes, Evelyne Chaput, Hans Richter, G. Martin Benson

Publikováno v: Journal of Lipid Research, Vol 54, Iss 5, Pp 1283-1299 (2013)

Modulating bile acid synthesis has long been considered a good strategy by which to improve cholesterol homeostasis in humans. The farnesoid X receptor (FXR), the key regulator of bile acid synthesis, was, therefore, identified as an interesting targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2589bd9cc5d5aaab7eb0a90baccea7
http://www.sciencedirect.com/science/article/pii/S0022227520421674