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Akademický článek

LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery

Autor: Shobini Jayaraman, Antonio Pérez, Inka Miñambres, Jose Luis Sánchez-Quesada, Olga Gursky

Publikováno v: Journal of Lipid Research, Vol 64, Iss 11, Pp 100451- (2023)

Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear. We explored how obesity and weight loss aft

Externí odkaz: https://doaj.org/article/d14020bb1f5041e1a8835ebefdc1016f

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Akademický článek

Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding[S]

Autor: Shi-jun Deng, Adekunle Alabi, Hong-mei Gu, Ayinuer Adijiang, Shucun Qin, Da-wei Zhang

Publikováno v: Journal of Lipid Research, Vol 60, Iss 3, Pp 516-527 (2019)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth fac

Externí odkaz: https://doaj.org/article/20e22f29dc094509a2ae980a6bfa0d83

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Akademický článek

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Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding[S]

Autor: Adekunle Alabi, Shucun Qin, Hong-mei Gu, Ayinuer Adijiang, Da-Wei Zhang, Shijun Deng

Publikováno v: Journal of Lipid Research, Vol 60, Iss 3, Pp 516-527 (2019)
Journal of Lipid Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc27d55c4db66159b77fa0448fa0aaa2
http://www.sciencedirect.com/science/article/pii/S0022227520326158

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Akademický článek

Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin

Autor: Lien B. Nguyen, Sarah Shefer, Gerald Salen, G.S. Tint, Frank Ruiz, John Bullock

Publikováno v: Journal of Lipid Research, Vol 42, Iss 2, Pp 195-200 (2001)

The effects of feeding cholesterol, sitosterol, and lovastatin on cholesterol absorption, biosynthesis, esterification, and LDL receptor function were examined in the rat jejunal mucosa. Cholesterol absorption was measured by the dual-isotope plasma

Externí odkaz: https://doaj.org/article/fe2ec2f5c03d4b7fbbb09e3bb8d73a77

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On the possible existence of a liver LDL-ostat, and its malfunctioning in familial hypercholesterolemia

Autor: Luis Teixeira da Costa

Publikováno v: Medical hypotheses. 147

The investigation of familial hypercholesterolemia (FH) and its relationship to atherosclerosis has led to enormous scientific and medical progress, including the identification of genetic defects underlying FH, the elucidation of molecular mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318e8f1999e76c37fdcea5e64b0f2d81
https://pubmed.ncbi.nlm.nih.gov/33515861

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Akademický článek

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The perlecan LDL-binding receptor needs sugar: Implication of perlecan core protein interaction with LDL for atherosclerosis

Autor: Yu-Xin Xu

Publikováno v: Receptors & Clinical Investigation.

Cardiovascular disease (CVD) is the deadliest disease in the US and finding cures for CVD has been a pressing and challenging problem in biomedical science. Atherosclerosis is a pathological condition caused by an elevated plasma LDL cholesterol leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16f65560015bb6d31f14162be66079fe
https://doi.org/10.14800/rci.867

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Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan

Autor: Hajime Nawata, Kunihisa Kobayashi, Toyoshi Inoguchi, Naotaka Sekiguchi, Noriyuki Sonoda

Publikováno v: Biochemical and Biophysical Research Communications. 335:66-70

The aim of this study was to test the possibility that adiponectin has an antiatherogenic effect through the inhibition of LDL binding to proteoglycans, an initial event in atherogenesis. Both full-length and globular adiponectin inhibited LDL bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd35d8a9392d128c35061adf23fd98e
https://doi.org/10.1016/j.bbrc.2005.07.048

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Androgens: New Effects on Proteoglycan Biosynthesis and Its Consequences for Atherosclerosis

Autor: Peter J. Little, Krishnankutty Sudhir, Julie Nigro, Narin Osman

Publikováno v: The Scientific World Journal
The Scientific World Journal, Vol 5, Pp 521-526 (2005)

The pro- and antiatherogenic role of sex hormones is very controversial. These hormones have metabolic actions, but may also display actions directly on cells of the vasculature involved in atherosclerosis. We recently examined the effect of the male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c712c16f3ec32456548715a7620a4ea
http://europepmc.org/articles/PMC5936535

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