LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery

Autor: Shobini Jayaraman, Antonio Pérez, Inka Miñambres, Jose Luis Sánchez-Quesada, Olga Gursky

Publikováno v: Journal of Lipid Research, Vol 64, Iss 11, Pp 100451- (2023)

Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear. We explored how obesity and weight loss aft

Externí odkaz: https://doaj.org/article/d14020bb1f5041e1a8835ebefdc1016f

“Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation

Autor: Roper, Barnaby W.R., Tiede, Christian, Abdul-Zani, Izma, Cuthbert, Gary A., Jade, Dhananjay, Al-Aufi, Ahmed, Critchley, William R., Saikia, Queen, Homer-Vanniasinkam, Shervanthi, Sawamura, Tatsuya, McPherson, Michael J., Harrison, Michael A., Tomlinson, Darren C., Ponnambalam, Sreenivasan

Publikováno v: In Journal of Biological Chemistry November 2023 299(11)

LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice.

Autor: Volpatti LR; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, United States.; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, United States., de Matos SN; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Medical Scientist Training Program, Pritzker School of Medicine, University of Chicago, IL, 60637, United States., Borjas G; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Reda J; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Watkins EA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Zhou Z; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Biological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL 60637, United States., Nguyen M; Animal Resources Center, University of Chicago, Chicago, IL 60637, United States., Solanki A; Animal Resources Center, University of Chicago, Chicago, IL 60637, United States., Fang Y; Biological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL 60637, United States.; Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, University of Chicago, Chicago, IL, USA.; Committee on Molecular Medicine, University of Chicago, Chicago, IL, 60637, United States., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Committee on Immunology, University of Chicago, Chicago, IL 60637, United States.; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.

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Surface properties of LDL-binding lymphocytes in human peripheral blood.

Autor: Hiramatsu, Kazuko¹, Sakai, H.¹, Endoh, M.¹, Arimori, S.¹

Publikováno v: Immunology. Mar1980, Vol. 39 Issue 3, p311-316. 6p.