Výsledky vyhledávání - "LDL/deficiency"

PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice

Autor: de Jong, Laura M, Zhang, Zhengzheng, den Hartog, Yvette, Sijsenaar, Timothy J P, Martins Cardoso, Renata, Manson, Martijn L, Hankemeier, Thomas, Lindenburg, Peter W, Salvatori, Daniela C F, Van Eck, Miranda, Hoekstra, Menno, Anatomie en fysiologie, CS_Locomotion, CS_Cancer

Publikováno v: Scientific Reports, 12(1)
Scientific Reports, 12(1), 1. NLM (Medline)
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Scientific Reports

Protein arginine methyltransferase 3 (PRMT3) is a co-activator of liver X receptor capable of selectively modulating hepatic triglyceride synthesis. Here we investigated whether pharmacological PRMT3 inhibition can diminish the hepatic steatosis exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff1a6ab8a8e2e1f41477b08f243f05
http://hdl.handle.net/1887/3279356

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TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

Autor: Shizuya Yamashita, M. Mahmood Hussain, Daniel J. Rader, Jahangir Iqbal, Marit Westerterp, Masahiro Koseki, Jay H. Lefkowitch, Alan R. Tall, Joanne Hsieh, Ikuyo Ichi, Robin B. Chan, Liana Tascau, Matthew M. Molusky, Carrie L. Welch, Sandra Abramowicz, Shunichi Takiguchi, Emi Yakushiji, Gilbert Di Paolo

Publikováno v: Nature
Nature, 535:7611, 303-307. Nature Publishing Group

Cellular mechanisms that mediate steatohepatitis, an increasingly prevalent condition in the Western world for which no therapies are available, are poorly understood. Despite the fact that its synthetic agonists induce fatty liver, the liver X recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09979db7c9fd77e84dfeb0184b7bfcaf
https://doi.org/10.1038/nature18628

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Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency

Autor: Andrew J. Murphy, Marit Westerterp, Ira Tabas, Ayelet Gonen, Joseph L. Witztum, Manikandan Subramanian, Alan R. Tall, Mi Wang, Carrie L. Welch, Sandra Abramowicz

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 34(5), 976-984. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis, and vascular biology, 34(5), 976-984. LIPPINCOTT WILLIAMS & WILKINS

Objective— Coronary heart disease is associated with monocytosis. Studies using animal models of monocytosis and atherosclerosis such as ApoE −/− mice have shown bone marrow (BM) hematopoietic stem and multipotential progenitor cell (HSPC) expa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2f2ebdee33cce30b41738784eef6aa
https://doi.org/10.1161/atvbaha.113.303097

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Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

Publikováno v: Cell reports. 13(1):132-144

Enhanced glucose utilization can be visualized in atherosclerotic lesions and may reflect a high glycolytic rate in lesional macrophages, but its causative role in plaque progression remains unclear. We observe that the activity of the carbohydrate-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::105e45ab1a7e67ff3f3514758c278b30
https://doi.org/10.1016/j.celrep.2015.08.068

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Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

Autor: Qizhi Wang, Chien-Ping Liang, Alan R. Tall, Marit Westerterp, Michihiro Matsumoto, Domenico Accili, Carrie L. Welch, Takafumi Senokuchi, Seongah Han

Publikováno v: The Journal of Clinical Investigation, 119(4), 1029-1041. AMER SOC CLINICAL INVESTIGATION INC

Type 2 diabetes is associated with accelerated atherogenesis, which may result from a combination of factors, including dyslipidemia characterized by increased VLDL secretion, and insulin resistance. To assess the hypothesis that both hepatic and per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d776dcc399c9bfef259d802f6374a4
https://doi.org/10.1172/jci36523

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Activation of liver X receptor decreases atherosclerosis in Ldlr⁻/⁻ mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells

Autor: Andrew J. Murphy, Vusisizwe Ntonga, Mojdeh S. Kappus, Sandra Abramowicz, Alan R. Tall, Marit Westerterp, Carrie L. Welch

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 34(2), 279-284. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, thrombosis, and vascular biology, 34(2), 279-284. Lippincott Williams and Wilkins

Objective— Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) exert anti-inflammatory effects mediated by transrepression of nuclear fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8c82ff9b5fccd96ba9888e667573ee
https://pubmed.ncbi.nlm.nih.gov/24431422

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Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

Autor: Sarrazy, Vincent, Sore, Sophie, Viaud, Manon, Rignol, Guylène, Westerterp, Marit, Ceppo, Franck, Tanti, Jean-François, Guinamard, Rodolphe r., Gautier, Emmanuel L., Yvan-Charvet, Laurent

Publikováno v: Cell Reports
Cell Reports, 2015, 13 (1), pp.132-144. ⟨10.1016/j.celrep.2015.08.068⟩
Cell Reports, Elsevier Inc, 2015, 13 (1), pp.132-144. ⟨10.1016/j.celrep.2015.08.068⟩
Cell reports, 13(1), 132-144. CELL PRESS
Cell Reports, Vol 13, Iss 1, Pp 132-144 (2015)

International audience; Enhanced glucose utilization can be visualized in atherosclerotic lesions and may reflect a high glycolytic rate in lesional macrophages, but its causative role in plaque progression remains unclear. We observe that the activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::035a43cfb378cad593dae2af5c8ac7d3
https://hal.science/hal-03798234

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Immunization of LDL receptor-deficient mice with beta2-glycoprotein 1 or human serum albumin induces a more inflammatory phenotype in atherosclerotic plaques

Autor: Geindre, Sylvie Françoise, Kwak, Brenda, Pelli, Graziano, Roth, Isabelle, Satta Poschung, Nathalie, Fish, Richard, Reber, Guido, Mach, François, Kruithof, Egbert, De Moerloose, Philippe

Publikováno v: Thrombosis and Haemostasis, Vol. 97, No 1 (2007) pp. 129-38

Antiphospholipid antibodies are a risk factor for venous and arterial thrombosis and may contribute to the development of atherosclerosis.The aim of this study was to investigate whether antibodies to human beta2-glycoprotein 1 (beta2GP1), as a model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::99a1107f52c8ac4d95e2cd292281cb74
https://pubmed.ncbi.nlm.nih.gov/17200780

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