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Akademický článek

Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin beta-tigogenin cellobioside (CP-88818; tiqueside).

Autor: HJ Harwood, Jr, CE Chandler, LD Pellarin, FW Bangerter, RW Wilkins, CA Long, PG Cosgrove, MR Malinow, CA Marzetta, JL Pettini

Publikováno v: Journal of Lipid Research, Vol 34, Iss 3, Pp 377-395 (1993)

Natural and synthetic saponins inhibit cholesterol absorption and reduce plasma cholesterol levels in experimental animals and are therefore of potential pharmacologic utility in the treatment of hypercholesterolemia. To determine the effects of this

Externí odkaz: https://doaj.org/article/e4d9545031ae4c949171ba21c7e49487

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Akademický článek

Kinetics of low-density lipoprotein receptor activity in Hep-G2 cells: derivation and validation of a Briggs-Haldane-based kinetic model for evaluating receptor-mediated endocytotic processes in which receptors recycle.

Autor: Harwood HJ Jr; Department of Metabolic Diseases, Pfizer Central Research, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Pellarin LD

Publikováno v: The Biochemical journal [Biochem J] 1997 May 01; Vol. 323 ( Pt 3), pp. 649-59.

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Akademický článek

3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors.

Autor: Harwood HJ Jr; Department of Metabolic Diseases, Pfizer Central Research, Pfizer Inc., Groton, CT 06340, USA., Barbacci-Tobin EG, Petras SF, Lindsey S, Pellarin LD

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1997 Mar 21; Vol. 53 (6), pp. 839-64.

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Akademický článek

Autor: Harwood HJ Jr; Department of Metabolic Diseases and Exploratory Toxicology, Pfizer Central Research, Pfizer, Inc., Groton, CT 06340., Chandler CE, Pellarin LD, Bangerter FW, Wilkins RW, Long CA, Cosgrove PG, Malinow MR, Marzetta CA, Pettini JL, et. al.

Publikováno v: Journal of lipid research [J Lipid Res] 1993 Mar; Vol. 34 (3), pp. 377-95.

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Akademický článek

Efficacy, tissue distribution and biliary excretion of methyl (3R*,5S*)-(E)-3,5-dihydroxy-9,9-diphenyl-6,8-nonadienoate (CP-83101), a hepatoselective inhibitor of HMG-CoA reductase activity in the rat.

Autor: Harwood HJ Jr; Department of Metabolic Diseases, Pfizer Inc., Groton, CT 06340., Silva M, Chandler CE, Mikolay L, Pellarin LD, Barbacci-Tobin E, Wint LT, McCarthy PA

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1990 Sep 15; Vol. 40 (6), pp. 1281-93.

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