Zobrazeno 1 - 10
of 31
pro vyhledávání: '"LD, lipid droplet"'
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Autor:
Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,
Autor:
Giacomo P. Comi, Amalia Gastaldelli, Roberto Piciotti, Anna Ludovica Fracanzani, S. Sabatini, Marica Meroni, Paola Dongiovanni, Massimiliano Ruscica, Giorgio Soardo, Anna Alisi, Luca Miele, Fabrizia Carli, Francesco Fortunato, Chiara Macchi, Veronica Erconi, Miriam Longo, Dario Ronchi, Erika Paolini, Luca Valenti
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 759-788 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 759-788 (2022)
Background & Aims The I148M Patatin-like Phospholipase Domain-containing 3 (PNPLA3), the rs641738 in the Membrane bound O-acyltransferase domain containing 7-transmembrane channel-like 4 (MBOAT7-TMC4) locus, and the E167K Transmembrane 6 Superfamily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07a31c4805b1bb37b98045b846a635c
http://hdl.handle.net/11390/1218302
http://hdl.handle.net/11390/1218302
Autor:
N. Castex Rizzi, Thérèse Nocera, Jean-Hilaire Saurat, L. Garidou, J. Le Digabel, C. Lauze, Gwendal Josse, Fabienne Fontao, Olivier Sorg
Publikováno v:
JID Innovations, Vol 1, Iss 4, Pp 100057-(2021)
JID Innovations
JID Innovations
In adipocytes and sebocytes, lipid droplet proteins control the storage of lipids in organized droplets and their release on demand. The contribution of lipid droplet proteins to the pathogenesis of acne is plausible because they control the levels o
Autor:
Nesrin Kartal Ozer, Tugce Demirel-Yalciner, Ceren Avcilar, Tuna Felix Samanci, Dyana Sari, Erdi Sozen
Publikováno v:
Metabolism Open
Metabolism Open, Vol 12, Iss, Pp 100138-(2021)
Metabolism Open, Vol 12, Iss, Pp 100138-(2021)
Objective Increased fatty acid and triglyceride synthesis in liver, majorly modulated by Sterol Regulator Elementing Binding Protein 1c (SREBP1c), is one of the main features of non-alcoholic fatty liver disease (NAFLD). In the present study, we aime
Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet
Autor:
Gavin Fredrickson, Fanta Barrow, Michael W. Lopresti, Douglas G. Mashek, Arnav S. Desai, Xavier S. Revelo, Breann Abernathy, Wenqi Cui
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100133-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100133-(2021)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets in hepatocytes. NAFLD development and progression is associated with an increase in hepatic cholesterol levels and decreased autophagy and lipophagy flux.
Autor:
Masanobu Morita, Yu Yamaguchi, Fumitoshi Irie, Yu Mei, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa, Rina Otsuka, Takuro Matsuzawa
Publikováno v:
The Journal of Biological Chemistry
Heparan sulfate (HS), a highly sulfated linear polysaccharide, is involved in diverse biological functions in various tissues. Although previous studies have suggested a possible contribution of HS to the differentiation of white adipocytes, there ha
Autor:
Sophie, Honeder, Tamara, Tomin, Laura, Nebel, Jürgen, Gindlhuber, Katarina, Fritz-Wallace, Maximilian, Schinagl, Christoph, Heininger, Matthias, Schittmayer, Nassim, Ghaffari-Tabrizi-Wizsy, Ruth, Birner-Gruenberger
Publikováno v:
Molecular & Cellular Proteomics : MCP
Cancer cells undergo complex metabolic adaptations to survive and thrive in challenging environments. This is particularly prominent for solid tumors, where cells in the core of the tumor are under severe hypoxia and nutrient deprivation. However, su
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100093-(2021)
Journal of Lipid Research
Journal of Lipid Research
The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play roles in hepatic triacylglycer
Publikováno v:
The Journal of Biological Chemistry
The envelopment of hepatitis C virus (HCV) is believed to occur primarily in the endoplasmic reticulum (ER)-associated membrane, and the translocation of viral Core protein from lipid droplets (LDs) to the ER is essential for the envelopment of viral