Genome-wide circadian regulation: A unique system for computational biology

Autor: Lingying Sun, Junjie Ma, Christoph W. Turck, Pin Xu, Guang-Zhong Wang

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1914-1924 (2020)

Circadian rhythms are 24-hour oscillations affecting an organism at multiple levels from gene expression all the way to tissues and organs. They have been observed in organisms across the kingdom of life, spanning from cyanobacteria to humans. In mam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3e2f2b6b0f53b6f9b9f0b638c1d68b
https://pubmed.ncbi.nlm.nih.gov/32774786

Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease

Autor: Juliet Aungier, A. Jennifer Morton, Koliane Ouk

Publikováno v: Neurobiology of Sleep and Circadian Rhythms, Vol 2, Iss, Pp 27-38 (2017)
Neurobiology of Sleep and Circadian Rhythms

The circadian disruption seen in patients of Huntington's disease (HD) is recapitulated in the R6/2 mouse model. As the disease progresses, the activity of R6/2 mice increases dramatically during the rest (light) period and decreases during the activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603cddf09cbee2743c20cb0c06d6a13e
https://www.repository.cam.ac.uk/handle/1810/262503

Running on time: the role of circadian clocks in the musculoskeletal system

Autor: Michal, Dudek, Qing-Jun, Meng

Publikováno v: Biochemical Journal

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues.

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https://pubmed.ncbi.nlm.nih.gov/25195734

Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour

Autor: David K. Welsh, Louisa M-C Wang, Thomas J. O'Dell, Joanna M. Dragich, Irene H. Odom, Takashi Kudo, Christopher S. Colwell

Publikováno v: ASN neuro, vol 1, iss 3
ASN NEURO
Wang, LMC; Dragich, JM; Kudo, T; Odom, IH; Welsh, DK; O'Dell, TJ; et al.(2009). Expression of the circadian clock gene Period2 in the hippocampus: Possible implications for synaptic plasticity and learned behaviour. ASN Neuro, 1(3), 139-152. doi: 10.1042/AN20090020. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/20q0274p

Genes responsible for generating circadian oscillations are expressed in a variety of brain regions not typically associated with circadian timing. The functions of this clock gene expression are largely unknown, and in the present study we sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb7fad2144a224bb22088cfcd467038
https://escholarship.org/uc/item/20q0274p

Short exposure to an enriched environment accelerates plasticity in the barrel cortex of adult rats

Autor: V. Rema, Michael Armstrong-James, Ned Jenkinson, Ford F. Ebner

Publikováno v: Neuroscience

Cortical sensory neurons adapt their response properties to use and disuse of peripheral receptors in their receptive field. Changes in synaptic strength can be generated in cortex by simply altering the balance of input activity, so that a persisten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed07682244c8db5403df11d376d6bcd