Zobrazeno 1 - 10
of 57
pro vyhledávání: '"LCMV, Lymphocytic choriomeningitis virus"'
Autor:
M. Eyad Khorki, Tiffany Shi, Eileen E. Cianciolo, Ashley R. Burg, P. Chukwunalu Chukwuma, Jennifer L. Picarsic, Mary K. Morrice, E. Steve Woodle, Jonathan S. Maltzman, Autumn Ferguson, Jonathan D. Katz, Brian M. Baker, David A. Hildeman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSignificant evidence suggests a connection between transplant rejection and the presence of high levels of pre-existing memory T cells. Viral infection can elicit viral-specific memory T cells that cross-react with allo-MHC capable of dri
Externí odkaz:
https://doaj.org/article/555d23a18c6843c39ebce9e0a10efea5
Autor:
Michal Mark, Shlomit Reich-Zeliger, Erez Greenstein, Adi Biram, Benny Chain, Nir Friedman, Asaf Madi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The T cell receptor is generated by a process of random and imprecise somatic recombination. The number of possible T cell receptors which this process can produce is enormous, greatly exceeding the number of T cells in an individual. Thus, the likel
Externí odkaz:
https://doaj.org/article/5ac08b95eb704f838509dfccf648665c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Viral-based cancer therapies have tremendous potential, especially in the context of treating poorly infiltrated cold tumors. However, in tumors with intact anti-viral interferon (IFN) pathways, while some oncolytic viruses induce strong innate and a
Externí odkaz:
https://doaj.org/article/3b486f1f8165496fb9701eb771dd743c
Autor:
Benedikt Thelen, Vincent Schipperges, Paulina Knörlein, Jonas F. Hummel, Frederic Arnold, Laurence Kupferschmid, Christoph S. N. Klose, Sebastian J. Arnold, Melanie Boerries, Yakup Tanriver
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of
Externí odkaz:
https://doaj.org/article/4c5f1626cfc8418480d9a58bd7d61b97
Autor:
Gennady Bocharov, Dmitry Grebennikov, Paula Cebollada Rica, Eva Domenjo-Vila, Valentina Casella, Andreas Meyerhans
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplic
Externí odkaz:
https://doaj.org/article/87ea57d488d74c53a432d7e29096f2ed
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chronic viral infections where the antigen persists long-term, induces an exhaustion phenotype in responding T cells. It is now evident that immune checkpoints on T cells including PD-1, CTLA-4, and PSGL-1 (Selplg) are linked with the differentiation
Externí odkaz:
https://doaj.org/article/c91548b5f252491c881c17c8abe287b1
Autor:
Henning Lauterbach, Sarah Schmidt, Kia Katchar, Xiaoping Qing, Corinne Iacobucci, Andy Hwang, Katia Schlienger, Ursula Berka, Josipa Raguz, Sarah Ahmadi-Erber, Timo Schippers, Felix Stemeseder, Daniel D. Pinschewer, Igor Matushansky, Klaus K. Orlinger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Engineered viral vectors represent a promising strategy to trigger antigen-specific antitumor T cell responses. Arenaviruses have been widely studied because of their ability to elicit potent and protective T cell responses. Here, we provide an overv
Externí odkaz:
https://doaj.org/article/83895df6536743b1a3a0d3687cec5f20
Autor:
Alexander Yermanos, Nike Julia Kräutler, Alessandro Pedrioli, Ulrike Menzel, Victor Greiff, Tanja Stadler, Annette Oxenius, Sai T. Reddy
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Antibody repertoire sequencing provides a molecular fingerprint of current and past pathogens encountered by the immune system. Most repertoire studies in humans require measuring the B cell response in the blood, resulting in a large bias to the IgM
Externí odkaz:
https://doaj.org/article/cf7cb86634fe4202a6192aca79e114c4
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Persistent virus infection can drive CD8+ T-cell responses which are markedly divergent in terms of frequency, phenotype, function, and distribution. On the one hand viruses such as Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 can drive T-cell
Externí odkaz:
https://doaj.org/article/faafdabf1f4f412fa63f37366ef6fbad
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