Zobrazeno 1 - 10
of 45
pro vyhledávání: '"LCA, lithocholic acid"'
Autor:
Michael Goedken, Grace L. Guo, Brian Buckley, Bo Kong, Anita M. Brinker, Rulaiha Elizabeth Taylor, Daniel Rizzolo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3847-3856 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3528a74d648335c5d6495523367f011
http://www.sciencedirect.com/science/article/pii/S2211383521001891
http://www.sciencedirect.com/science/article/pii/S2211383521001891
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1789-1812 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d001e27a816f9de7d75ff16dd2143ec
http://www.sciencedirect.com/science/article/pii/S2211383520307279
http://www.sciencedirect.com/science/article/pii/S2211383520307279
Autor:
Justine Gillard, Laure-Alix Clerbaux, Bart Staels, Anne Tailleux, Isabelle Leclercq, Laure B. Bindels, Maxime Nachit, Christine Sempoux
Publikováno v:
JHEP reports, vol. 4, no. 1, pp. 100387
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reports
JHEP Reports, Vol 4, Iss 1, Pp 100387-(2022)
JHEP reports, Vol. 4, no.1, p. 100387 [1-13] (2022)
JHEP Reports
Background & Aims Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation and fibrosis. Hence, BAs returning to the liver after enteric secretion, modification and reabsorption may contribute to the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f803f3cd8976e73d533d8b1885ead5
https://serval.unil.ch/notice/serval:BIB_8BED7E41CA16
https://serval.unil.ch/notice/serval:BIB_8BED7E41CA16
Autor:
Petia Shipkova, Giridhar S. Tirucherai, Arun J. Sanyal, Diane E. Shevell, Benjamin E. Decato, Colleen A. McNaney, Yi Luo, Edgar D. Charles, Abraham Apfel
Publikováno v:
JHEP Reports
Background & Aims Increased serum bile acids (BAs) have been observed in patients with non-alcoholic steatohepatitis (NASH). Pegbelfermin (PGBF), a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21), signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c523b47362c4cc87193b195c73edfb6d
https://pubmed.ncbi.nlm.nih.gov/34977519
https://pubmed.ncbi.nlm.nih.gov/34977519
Autor:
Spatz, Madeleine, Ciocan, Dragos, Merlen, Gregory, Rainteau, Dominique, Humbert, Lydie, Gomes-Rochette, Neuza, Hugot, Cindy, Trainel, Nicolas, Mercier-Nomé, Françoise, Domenichini, Séverine, Puchois, Virginie, Wrzosek, Laura, Ferrere, Gladys, Tordjmann, Thierry, Perlemuter, Gabriel, Cassard, Anne-Marie
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100230-(2021)
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
JHEP Reports
Background & Aims Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes. We examined the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae520b76500b6b211e8c427c2e781d78
http://www.sciencedirect.com/science/article/pii/S2589555921000069
http://www.sciencedirect.com/science/article/pii/S2589555921000069
Autor:
Grzych, Guillaume, Chavez-Talavera, Oscar, Descat, Amandine, Thuillier, Dorothee, Verrijken, An, Kouach, Mostafa, Legry, Vanessa, Verkindt, Helene, Raverdy, Violeta, Legendre, Benjamin, Caiazzo, Robert, Van Gaal, Luc, Goossens, Jean-Francois, Paumelle, Rejane, Francque, Sven, Pattou, Francois, Haas, Joel T., Tailleux, Anne, Staels, Bart
Publikováno v:
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100222-(2021)
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100222-(2021)
Background & Aims Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::74e69ecb4a62b415846d1ee012802a9c
https://www.hal.inserm.fr/inserm-03173334/document
https://www.hal.inserm.fr/inserm-03173334/document
Autor:
Hsiao D. Lieu, Gideon M. Hirschfield, Arun J. Sanyal, Stephen A. Harrison, Lei Ling, Ulrich Beuers, Alex M. DePaoli
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier
Summary Background & Aims Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7001e197981d0d939e7dc5af50542f
https://pubmed.ncbi.nlm.nih.gov/33898959
https://pubmed.ncbi.nlm.nih.gov/33898959
Autor:
Matthew R. Henn, Meghan Chafee, Bharat K. Misra, Liyang Diao, John G. Aunins, Brian G. Feagan, Jennifer R. Wortman, Amelia Tomlinson, Roger J. Pomerantz, Peng Zhao, Sherry Wang-Weigand, Michele Trucksis, Barbara H. McGovern, Christopher B. Ford, David N. Cook, William J. Sandborn, Patricia Bernardo, David I. Lichter, Curtis Huttenhower, Sheri L. Simmons, Edward J. O’Brien
Publikováno v:
Gastroenterology
Background & Aims Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17da58568b427b6d165f82d1d01a222d
http://europepmc.org/articles/PMC7402096
http://europepmc.org/articles/PMC7402096
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1463-1482 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1463-1482 (2021)
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that continually shapes host pathophysiological responses. Despite readily available abundant metagenomic data, the functional dynamics of gut microbiota remain to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49158aad54b8f52d7f884de448f920a4
https://pubmed.ncbi.nlm.nih.gov/33610769
https://pubmed.ncbi.nlm.nih.gov/33610769
Gender and Age Differences in the Hepatic Consequences of 'Humanized' Bile Acid Compositions in Mice
Autor:
Xiao Zhao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1207-1208 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background and Aims Bile acids (BAs) aid intestinal fat absorption and exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in BA metabolism between humans and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb34542b4b2a350917b16d0472de7f4
https://doi.org/10.1016/j.jcmgh.2021.01.005
https://doi.org/10.1016/j.jcmgh.2021.01.005