Zobrazeno 1 - 10 of 140 pro vyhledávání: '"LC, liquid chromatography"'
1
Infrared multiple photon dissociation (IRMPD) spectroscopy and its potential for the clinical laboratory
Autor: Matthew James Carlo, Amanda Patrick
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 14-25 (2022)
Journal of Mass Spectrometry and Advances in the Clinical Lab
Graphical abstract
Infrared multiple photon dissociation (IRMPD) spectroscopy is a powerful tool used to probe the vibrational modes–and, by extension, the structure—of an ion within an ion trap mass spectrometer. Compared to traditional FTI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1896b9cca9d995eb7964b767cf209078
http://www.sciencedirect.com/science/article/pii/S2667145X2100033X
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2
Lipid analysis by ion mobility spectrometry combined with mass spectrometry: A brief update with a perspective on applications in the clinical laboratory
Autor: Joshua Dubland
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 7-13 (2022)
Ion mobility spectrometry (IMS) is an analytical technique where ions are separated in the gas phase based on their mobility through a buffer gas in the presence of an electric field. An ion passing through an IMS device has a characteristic collisio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae14ffaafac42c15bc615e2dc76a45d
http://europepmc.org/articles/PMC8703053
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3
Ravulizumab: Characterization and quantitation of a new C5 inhibitor using isotype specific affinity purification and high-resolution mass spectrometry
Autor: Maria Alice V. Willrich, Paula M. Ladwig
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 21, Iss, Pp 10-18 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab
Highlights • Ravulizumab and eculizumab differ by 4 amino acids in their heavy chains. • Validation of ravulizumab LDT with quantitation by intact light chain. • TOF-MS allows for detection by heavy chain.
Introduction Ravulizumab (RAVUL)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88685fcc88f512f223cf9cedd64e9176
http://www.sciencedirect.com/science/article/pii/S2667145X21000146
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4
Direct detection of OXA-48-like carbapenemase variants with and without co-expression of an extended-spectrum β-lactamase from bacterial cell lysates using mass spectrometry
Autor: Scott R. Kronewitter, James L. Stephenson, Arvind Verma, William M. McGee, Jason R. Neil, Marjaana Viirtola
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 25-34 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab
Highlights • LC-MS methods are used to identify intact OXA-48 like enzymes from bacterial lysates. • Individual protein variants of the OXA-48 like carbapenemases can be detected with tandem mass spectrometry. • OXA-48 like carbapenemases can b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7805096e04f78395d3d7e73173308107
http://www.sciencedirect.com/science/article/pii/S2667145X21000080
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5
Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach
Autor: Bojana Rakic, Hilary Vallance, Joshua A. Dubland, Graham Sinclair
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 1-10 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab
Highlights • Analysis of 2-methylcitric acid, methylmalonic acid, and homocysteine in DBS. • A dual derivatization LC-MS/MS strategy developed for use in second-tier NBS. • Second-tier panel replaces multiple initial follow-up tests. • Improv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50beebd48c7a916d499a13356b9284c0
https://doi.org/10.1016/j.jmsacl.2021.03.001
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6
Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo
Autor: Ke Yang, Min Qin, Ping zhang, Hong Xia, Yirong Chen, Hanjun Qin, Yifang Zhang, Bin Yu, Ling Ren, Jun Yang, Yu Chai
Publikováno v: Journal of Orthopaedic Translation, Vol 27, Iss, Pp 77-89 (2021)
Journal of Orthopaedic Translation
Objective The antibacterial activity of copper (Cu)-alloy biomaterials has shown a great potential in clinical application. Here, we evaluated the osteogenesis and antibacterial effects of Ti6Al4V-6.5wt%Cu alloy in an in vivo model of infected bone d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfaf85b175e6d1a33871d19af87138d
https://doi.org/10.1016/j.jot.2020.10.004
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7
Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
Autor: Bruce D. Hammock, A. F. S. Mello, Natalie J. Török, Fawaz G. Haj, Jun Yang, Ming-Fo Hsu, Bryan Chu, Christophe Morisseau, Jeff Cheng, Shinichiro Koike
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37aec2ab2970ef64d585a65ffea8d3
http://www.sciencedirect.com/science/article/pii/S2352345X20301624
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8
Unique distribution of ellagitannins in ripe strawberry fruit revealed by mass spectrometry imaging
Autor: Hirofumi Enomoto
Publikováno v: Current Research in Food Science, Vol 4, Iss, Pp 821-828 (2021)
Current Research in Food Science
Ellagitannins (ETs) are hydrolysable tannins composed of a polyol core, primarily glucose, which is esterified with hexahydroxydiphenic acid (HHDP), and in some cases, gallic acid. ETs are the major phenolic compounds found in strawberries and may co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442fc3d9e2fe0461bd067d8438a73416
http://www.sciencedirect.com/science/article/pii/S2665927121000952
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9
Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification
Autor: Harald John, Horst Thiermann
Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 19, Iss, Pp 20-31 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab
Highlights • Evidence of poisoning with organophosphorus (OP) nerve agents requires biomedical verification. • OP nerve agents undergo common biotransformation pathways producing valuable biomarkers. • Internationally accepted methods target re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41b5a1b0825181b488f72690c50353f
http://www.sciencedirect.com/science/article/pii/S2667145X21000018
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10
In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging
Autor: Zhonghua Wang, Zeper Abliz, Meiling Huo, Chunyan Yang, Bingshu He, Wenqing Fu, Yaqi Liu, Jinfeng Wei
Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1083-1093 (2020)
Acta Pharmaceutica Sinica. B
Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e79605efb06e65af3a2ee9300ab4fcf
http://www.sciencedirect.com/science/article/pii/S2211383519310718
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