Výsledky vyhledávání - "LBP, lipopolysaccharide binding protein"

Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet

Autor: Anthony M. Diomino, David A. Brenner, Hyeok Choon Kwon, Gibraan Rahman, Sara Brin Rosenthal, Tatiana Kisseleva, Linshan Shang, Souradipta Ganguly, Ruoyu Wang, Debanjan Dhar, Rob Knight, Pejman Soorosh, Mojgan Hosseini, Yanhan Wang, Bernd Schnabl, German R. Aleman Muench

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 891-920 (2021)
Cellular and molecular gastroenterology and hepatology, vol 12, iss 3

Background & Aims How benign liver steatosis progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC) remains elusive. NASH progression entails diverse pathogenic mechanisms and relies on complex cross-talk betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b88e146fb92107eb8ff000fbb198af7
https://doi.org/10.1016/j.jcmgh.2021.05.010

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Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 54, Iss, Pp 101388-(2021)

Objective Obesity represents a growing health problem that is reaching pandemic dimensions and lacks effective cures, thus highlighting an urgent need for better mechanistic understanding and new therapeutic strategies. Unlike transcription, the func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae7e360f96f5ac2a1a8c0ec2bedd48
http://europepmc.org/articles/PMC8711066

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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options

Autor: Rahul Singh, Sean N. Avedissian, Vinod D. Chaudhari, Anthony T. Podany, Ganesh P. Pawar, Deepak B. Salunke, Rohini Emani, Shetty Ravi Dyavar, Courtney V. Fletcher

Publikováno v: Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111794-(2021)
Biomedicine & Pharmacotherapy

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III interferons and higher levels of inflammatory mediators upon SARS-CoV2 infection contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0354b118d4b1b6946482534bec88d63f
http://www.sciencedirect.com/science/article/pii/S075333222100576X

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A Proteomics-Based Assessment of Inflammation Signatures in Endotoxemia

Autor: Robert F. Storey, Manu Shankar-Hari, Ian Sabroe, Friederike Cuello, Ursula Mayr, Mark R Thomas, Manuel Mayr, Sean A. Burnap, Ajay M. Shah

Publikováno v: Molecular & Cellular Proteomics : MCP

We have previously shown that multimers of plasma pentraxin-3 (PTX3) were predictive of survival in patients with sepsis. To characterize the release kinetics and cellular source of plasma protein changes in sepsis, serial samples were obtained from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71832172395a7e488649fdc2bed40f9a
https://pubmed.ncbi.nlm.nih.gov/33288685

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Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Autor: Thomas Gautier, Kevin van Dongen, Émilie Charron, Stéphane Mandard, Valérie Deckert, Jean-Paul Pais de Barros, Hélène Choubley, Jérôme Labbé, Naig Le Guern, Jacques Grober, Alois Dusuel, Laurent Lagrost

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100011-(2021)
Journal of Lipid Research, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩

International audience; Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd34527c453da1363375ba2659935a9
https://www.hal.inserm.fr/inserm-03052637

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Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects

Autor: M D Van Loan, Nancy Rivera, Bruce D. Hammock, Romina Sacchi, T S Rogers-Soeder, J B German, Elizabeth Beals, Erik R. Gertz, Elieke Demmer, Shizuo G. Kamita, Jennifer T. Smilowitz, Angela M. Zivkovic

Publikováno v: Journal of Nutritional Science

CVD and associated metabolic diseases are linked to chronic inflammation, which can be modified by diet. The objective of the present study was to determine whether there is a difference in inflammatory markers, blood metabolic and lipid panels and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b63c9118a81dcb3449155381e85270
http://europepmc.org/articles/PMC6498758

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Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function

Autor: Ina Bergheim, Finn Jung, Anika Nier, Cheng Jun Jin, Annette Brandt, Anja Baumann, José C. Fernández-Checa, Vicent Ribas, Carmen García-Ruiz

Publikováno v: Redox Biology
Redox Biology, Vol 21, Iss, Pp-(2019)
Digital.CSIC. Repositorio Institucional del CSIC
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Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide lacking universally accepted therapies. Studies suggest that coffee consumption is associated with a reduced risk of NAFLD; however, molecular mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b173ea7738b5f0fbb2100e259fb20393
https://hdl.handle.net/11353/10.1172206

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Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome:findings from a randomised phase 2 trial

Autor: Mark Hvistendahl, Nikolaj Nerup, Palle Jeppesen, Rahim M. Naimi, Holger Jon Møller, Hendrik Vilstrup, Henning Grønbæk, A Steensberg, Lars Bo Svendsen, Michael Patrick Achiam, Rikard Ambrus

Publikováno v: Naimi, R M, Hvistendahl, M, Nerup, N, Ambrus, R, Achiam, M P, Svendsen, L B, Grønbæk, H, Møller, H J, Vilstrup, H, Steensberg, A & Jeppesen, P B 2019, ' Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome : findings from a randomised phase 2 trial ', EBioMedicine, vol. 46, pp. 444-451 . https://doi.org/10.1016/j.ebiom.2019.07.016
EBioMedicine, Vol 46, Iss, Pp 444-451 (2019)
EBioMedicine

Background: With the introduction of glucagon-like peptide-2 (GLP-2) in the treatment of short bowel syndrome (SBS), there is emerging evidence that GLP-2 may play a role in the restoration of the disturbed homeostatic feedback in the gut-liver axis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05947bfad093b676693c358f7a35acb1
https://curis.ku.dk/portal/da/publications/effects-of-glepaglutide-a-novel-longacting-glucagonlike-peptide2-analogue-on-markers-of-liver-status-in-patients-with-short-bowel-syndrome(dada8f5d-ba75-473f-a1ee-648f2566f6a1).html

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