Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses

Autor: Joanne E. Haughan, Jaclyn R. Missanelli, Youwen You, Darko Stefanovski, Lawrence R. Soma, Mary A. Robinson

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 45:273-282

Glaucine, an aporphine alkaloid with anti-tussive, anti-inflammatory, and anti-nociceptive properties, has been identified in post-race samples from racehorses. To investigate pharmacokinetics of glaucine in horses, a three-way crossover study of int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df5273f927bd3d856942af7b34fb96c
https://doi.org/10.1111/jvp.13057

Bayesian‐based withdrawal estimates using pharmacokinetic parameters for two capsaicinoid‐containing products administered to horses

Autor: Lawrence R. Soma, Youwen You, Darko Stefanovski, Raymond C. Boston, Mary A Robinson

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 44:349-358

Capsaicinoids deter horses from chewing on bandages and are applied topically to provide analgesia to musculoskeletal injuries. They are banned during competition due to their nerve blocking properties. The pharmacokinetics of oral (PO) and direct ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1a4e37db7af6b137b8b9cc191888ea
https://doi.org/10.1111/jvp.12939

Evaluation of the analgesic and pharmacokinetic properties of transdermally administered fentanyl in goats

Autor: Raymond C. Boston, Thomas P. Schaer, Lawrence R. Soma, Megan Burke, Jeffery A. Rudy

Publikováno v: Journal of Veterinary Emergency and Critical Care. 27:539-547

Objective Evaluate the analgesic properties and pharmacokinetics of transdermal fentanyl patches (TFPs) in goats. Design Prospective, randomized study. Setting Preclinical Testing Facility at a University Teaching Hospital. Animals Thirty-four adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16387d91cd8aeb4047703c38b0a4f780
https://doi.org/10.1111/vec.12644

Pharmacokinetics of xylazine after 2-, 4-, and 6-hr durations of continuous rate infusions in horses

Autor: Raymond C. Boston, Bernd Driessen, Klaus Hopster, Lawrence R. Soma, Charlotte Hopster-Iversen, Xiaoqing Li

Publikováno v: Hopster, K, Soma, L R, Li, X, Hopster-Iversen, C, Boston, R C & Driessen, B 2020, ' Pharmacokinetics of xylazine after 2-, 4-, and 6-hr durations of continuous rate infusions in horses ', Journal of Veterinary Pharmacology and Therapeutics, vol. 43, no. 6, pp. 557-564 . https://doi.org/10.1111/jvp.12873

Intravenous (i.v.) bolus administration of xylazine (XYL) (0.5 mg/kg) immediately followed by a continuous rate infusion (CRI) of 1 mg kg-1 hr-1 for 2, 4, and 6 hr produced immediate sedation, which lasted throughout the duration of the CRI. Heart ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac2e6351e002e945d141c9d97f35692
https://pubmed.ncbi.nlm.nih.gov/32424949

Confirmatory analysis of etanercept in equine plasma by LC-MS for doping control

Autor: Lawrence R. Soma, Fuyu Guan, Mary A. Robinson

Publikováno v: Drug Testing and Analysis. 9:1421-1431

Etanercept is a protein-based medication for the treatment of human patients with rheumatoid arthritis and other autoimmune-based diseases; its pharmacological action is to inhibit and antagonize tumour necrosis factor alpha. Etanercept was rumoured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae943274ae875648dec894c6fa6dd530
https://doi.org/10.1002/dta.2091