Zobrazeno 1 - 10
of 273
pro vyhledávání: '"LAURIE J. GOODYEAR"'
Autor:
Maria Vamvini, Pasquale Nigro, Tiziana Caputo, Kristin I. Stanford, Michael F. Hirshman, Roeland J.W. Middelbeek, Laurie J. Goodyear
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114481- (2024)
Summary: Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well established. Here, we tested the hypothesis that inguinal white adipose tissue (iWAT) adaptations are critical for these beneficial effects
Externí odkaz:
https://doaj.org/article/88025efcaf8643f6bf8474f6ef2ee74f
Autor:
Diego Hernández-Saavedra, J. Matthew Hinkley, Lisa A. Baer, Kelsey M. Pinckard, Pablo Vidal, Shinsuke Nirengi, Andrea M. Brennan, Emily Y. Chen, Niven R. Narain, Valerie Bussberg, Vladimir V. Tolstikov, Michael A. Kiebish, Christina Markunas, Olga Ilkayeva, Bret H. Goodpaster, Christopher B. Newgard, Laurie J. Goodyear, Paul M. Coen, Kristin I. Stanford
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109083- (2024)
Summary: Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (AC) (C12-C16) are lower in act
Externí odkaz:
https://doaj.org/article/1fa864323c024e6ea418512ba98137e4
Autor:
Hui Zhang, Laura K. Simpson, Nicholas P. Carbone, Michael F. Hirshman, Pasquale Nigro, Maria Vamvini, Laurie J. Goodyear, Roeland J.W. Middelbeek
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107226- (2023)
Summary: Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin
Externí odkaz:
https://doaj.org/article/be98f540f398432e8b078db8ce1f2cd0
Autor:
Pasquale Nigro, Maria Vamvini, Jiekun Yang, Tiziana Caputo, Li-Lun Ho, Nicholas P. Carbone, Danae Papadopoulos, Royce Conlin, Jie He, Michael F. Hirshman, Joseph D. White, Jacques Robidoux, Robert C. Hickner, Søren Nielsen, Bente K. Pedersen, Manolis Kellis, Roeland J.W. Middelbeek, Laurie J. Goodyear
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112392- (2023)
Summary: Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise train
Externí odkaz:
https://doaj.org/article/577f9f4134734bcd932687cedaaa5648
Autor:
Ana B. Alves-Wagner, Joji Kusuyama, Pasquale Nigro, Krithika Ramachandran, Nathan Makarewicz, Michael F. Hirshman, Laurie J. Goodyear
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101490- (2022)
Objective: A major factor in the growing world-wide epidemic of obesity and type 2 diabetes is the increased risk of transmission of metabolic disease from obese mothers to both first (F1) and second (F2) generation offspring. Fortunately, recent pre
Externí odkaz:
https://doaj.org/article/99f98cf2de3f4726aa17146ab40d6aa1
Autor:
Roeland J. W. Middelbeek, Piryanka Motiani, Nina Brandt, Pasquale Nigro, Jia Zheng, Kirsi A. Virtanen, Kari K. Kalliokoski, Jarna C. Hannukainen, Laurie J. Goodyear
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Background Short-term exercise training programs that consist of moderate intensity endurance training or high intensity interval training have become popular choices for healthy lifestyle modifications, with as little as two weeks of traini
Externí odkaz:
https://doaj.org/article/a19549efa3214843a3e54787aff95842
Autor:
Farnaz Shamsi, Ruidan Xue, Tian Lian Huang, Morten Lundh, Yang Liu, Luiz O. Leiria, Matthew D. Lynes, Elena Kempf, Chih-Hao Wang, Satoru Sugimoto, Pasquale Nigro, Kathrin Landgraf, Tim Schulz, Yiming Li, Brice Emanuelli, Srinivas Kothakota, Lewis T. Williams, Niels Jessen, Steen Bønløkke Pedersen, Yvonne Böttcher, Matthias Blüher, Antje Körner, Laurie J. Goodyear, Moosa Mohammadi, C. Ronald Kahn, Yu-Hua Tseng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is disso
Externí odkaz:
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe
Autor:
Christie M. Penniman, Pablo A. Suarez Beltran, Gourav Bhardwaj, Taylor L. Junck, Jayashree Jena, Kennedy Poro, Michael F. Hirshman, Laurie J. Goodyear, Brian T. O'Neill
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 203-220 (2019)
Objective: Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate mus
Externí odkaz:
https://doaj.org/article/93d1c05e592b4da0ba81a670a72c2b86
Autor:
André L. Queiroz, Sarah J. Lessard, Amanda T. Ouchida, Hygor N. Araujo, Dawit A. Gonçalves, Dimitrius Santiago P. Simões Fróes Guimarães, Bruno G. Teodoro, Kawai So, Enilza M. Espreafico, Michael F. Hirshman, Luciane C. Alberici, Isis do Carmo Kettelhut, Laurie J. Goodyear, Leonardo R. Silveira
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101226- (2021)
Objective: MicroRNAs (miRNA) are known to regulate the expression of genes involved in several physiological processes including metabolism, mitochondrial biogenesis, proliferation, differentiation, and cell death. Methods: Using “in silico” anal
Externí odkaz:
https://doaj.org/article/f16977abeca54a81845fd637f904eadd
Autor:
Adam C. Lehnig, Revati S. Dewal, Lisa A. Baer, Kathryn M. Kitching, Vitor Rosetto Munoz, Peter J. Arts, Devin A. Sindeldecker, Francis J. May, Hans P.M.M. Lauritzen, Laurie J. Goodyear, Kristin I. Stanford
Publikováno v:
iScience, Vol 11, Iss , Pp 425-439 (2019)
Summary: Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, a
Externí odkaz:
https://doaj.org/article/922906a2332b4a77b8a6ce173a7e8063