Iron homeostasis in the lung

Autor: ANDREW J GHIO, JENNIFER L TURI, FUNMEI YANG, LAURA M GARRICK, MICHAEL D GARRICK

Publikováno v: Biological Research, Vol 39, Iss 1, Pp 67-77 (2006)

Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposu

Externí odkaz: https://doaj.org/article/14f01eb7e5594346963eb417bf93b3ee

A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement

Autor: Lin Zhao, Michael D. Garrick, James F. Collins, Laura M. Garrick, Joleen M. Soukup, Andrew J. Ghio

Publikováno v: Biometals

Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion transporter (DMT1) is the major iron importer in enterocytes and erythroblasts. We have com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dba750fd0684a3c1f4189e5dd34b0d7
https://doi.org/10.1007/s10534-019-00207-2

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

Autor: Lin Zhao, Laura M. Garrick, Michael D. Garrick, Natascha A. Wolff, Frank Thévenod, Andrew J. Ghio

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that the divalent metal transporter 1 (DMT1) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b599a6dc6fbf63d818dea50b9593793
http://europepmc.org/articles/PMC5760699

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

Autor: Miguel Arredondo, Daniel Alvarez-Fischer, Natalia Mena, Laura M. Garrick, Charles Duyckaerts, Rita Raisman-Vozari, Stéphane Hunot, Lin Zhao, Véronique Sazdovitch, Etienne C. Hirsch, Marco T. Núñez, Annick Prigent, Julio Salazar, Michael D. Garrick

Publikováno v: Proceedings of the National Academy of Sciences. 105:18578-18583

Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in the SN of PD patients may cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5751201c67712e557eba9aa935ddfeb
https://doi.org/10.1073/pnas.0804373105

DMT1: Which metals does it transport?

Autor: Laura M. Garrick, Lin Zhao, Martin Knöpfel, Jerome A. Roth, Max Costa, Steven T. Singleton, Prasad N. Paradkar, H-C Kuo, Todd Davidson, Farida Vargas, Michael D. Garrick

Publikováno v: Biological Research, Vol 39, Iss 1, Pp 79-85 (2006)
Biological Research, Volume: 39, Issue: 1, Pages: 79-85, Published: 2006
Biological Research v.39 n.1 2006
SciELO Chile
CONICYT Chile
instacron:CONICYT
Scopus-Elsevier

DMT1-Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 - transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMTI also is important in non-transferrin bound iron uptake. It plays similar roles in Mn2+ traff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552a907e484ffcdda6c6f75077a875d0
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100009