Výsledky vyhledávání - "LARA M. GOMES"

Akademický článek

Effects of primaquine and chloroquine on oxidative stress parameters in rats

Autor: FRANCIANNE GIOVANELLA, GABRIELA K. FERREIRA, SAMIRA D.T. DE PRÁ, MILENA CARVALHO-SILVA, LARA M. GOMES, GISELLI SCAINI, RENATA C. GONÇALVES, MONIQUE MICHELS, LETÍCIA S. GALANT, LUIZA M. LONGARETTI, ANA LUIZA DAJORI, VANESSA M. ANDRADE, FELIPE DAL-PIZZOL, EMILIO L. STRECK, RENAN P. DE SOUZA

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 87, Iss 2 suppl, Pp 1487-1496 (2015)

Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA

Externí odkaz: https://doaj.org/article/536ad2fa26b544c59fd6288d96db81fc

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Akademický článek

Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

Autor: Camila O. Souza, Alexandre A. S. Teixeira, Edson A. Lima, Helena A. P. Batatinha, Lara M. Gomes, Milena Carvalho-Silva, Isabella T. Mota, Emilio L. Streck, Sandro M. Hirabara, José C. Rosa Neto

Publikováno v: Mediators of Inflammation, Vol 2014 (2014)

Palmitoleic acid (PMA) has anti-inflammatory and antidiabetic activities. Here we tested whether these effects of PMA on glucose homeostasis and liver inflammation, in mice fed with high-fat diet (HFD), are PPAR-α dependent. C57BL6 wild-type (WT) an

Externí odkaz: https://doaj.org/article/1087d1915e7b45c4968cb2d11db3d7f3

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Omega-3 fatty acid supplementation can prevent changes in mitochondrial energy metabolism and oxidative stress caused by chronic administration of L-tyrosine in the brain of rats

Autor: Jade de Oliveira, Patrícia F. Schuck, Gustavo C. Ferreira, Felipe Dal-Pizzol, Maria Luiza Gomes, Milena Carvalho-Silva, Lara M. Gomes, Giselli Scaini, Emilio L. Streck, Bruna K Ferreira

Publikováno v: Metabolic Brain Disease. 34:1207-1219

Deficiency of hepatic enzyme tyrosine aminotransferase characterizes the innate error of autosomal recessive disease Tyrosinemia Type II. Patients may develop neurological and developmental difficulties due to high levels of the amino acid tyrosine i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25495d3ccc6ab1a5cb20e3b913177a52
https://doi.org/10.1007/s11011-019-00411-6

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Role of antioxidant treatment on DNA and lipid damage in the brain of rats subjected to a chemically induced chronic model of tyrosinemia type II

Autor: Gustavo C. Ferreira, Adriani Paganini Damiani, Milena Carvalho-Silva, Giselli Scaini, Vanessa Moraes de Andrade, Jotele Fontana Agostini, Paula Ronsani Ferro, Samira Dal-Toé De Prá, Patrícia F. Schuck, Emilio L. Streck, Lara M. Gomes

Publikováno v: Molecular and Cellular Biochemistry. 435:207-214

Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044340545eb48a1d70dbcf42b28562c9
https://doi.org/10.1007/s11010-017-3070-5

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Evidence of hippocampal astrogliosis and antioxidant imbalance after L-tyrosine chronic administration in rats

Autor: Andreza Fabro de Bem, Jade de Oliveira, Emilio L. Streck, Samira Dal-Toé De Prá, Patrícia F. Schuck, Milena Carvalho-Silva, Giselli Scaini, Leticia B. Wessler, Flávio Henrique Reginatto, Carlos H. Blum-Silva, Lara M. Gomes

Publikováno v: Metabolic brain disease. 35(1)

Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a941d9c5361d6a042796089c367bd07
https://pubmed.ncbi.nlm.nih.gov/31705440

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Omega-3 Fatty Acids and Mood Stabilizers Alter Behavioural and Energy Metabolism Parameters in Animals Subjected to an Animal Model of Mania Induced by Fenproporex

Autor: Emilio L. Streck, Lara M. Gomes, Luiza Wilges Kist, Letícia J. Teixeira, João Quevedo, Edemilson Mariot, Maurício Reis Bogo, Milena Carvalho-Silva, Giselli Scaini, Camila O. Arent, Kizzy Cancelier, Joyce Rebelo, Isabella T. Mota

Publikováno v: Molecular Neurobiology. 54:3935-3947

Studies have shown that changes in energy metabolism are involved in the pathophysiology of bipolar disorder (BD). It was suggested that omega-3 (ω3) fatty acids have beneficial properties in the central nervous system and that this fatty acid plays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0338d1d40adf8932fc6e4573e4c9de54
https://doi.org/10.1007/s12035-016-9933-z

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Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Autor: Lara M. Gomes, Gabriela K. Ferreira, Milena Carvalho-Silva, Gislaine T. Rezin, Francieli Vuolo, Marcos Marques da Silva Paula, Emilio L. Streck, Elton Torres Zanoni, Eria Cardoso, Monique Michels, Felipe Dal-Pizzol

Publikováno v: Biochemistry and Cell Biology. 93:548-557

This study evaluated the parameters of oxidative stress and energy metabolism after the acute and long-term administration of gold nanoparticles (GNPs, 10 and 30 nm in diameter) in different organs of rats. Adult male Wistar rats received a single in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af43a5dd922a0da7f326a1b2fcf1f640
https://doi.org/10.1139/bcb-2015-0030

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Antioxidants Reverse the Changes in the Cholinergic System Caused by L-Tyrosine Administration in Rats

Autor: João Quevedo, Milena Carvalho-Silva, Giselli Scaini, Maurício Reis Bogo, Gustavo C. Ferreira, Maria Luiza Gomes, Pedro F. Deroza, Fernanda Malgarin, Airam B. de Moura, Alexandra I. Zugno, Patrícia F. Schuck, Eduardo Pacheco Rico, Lara M. Gomes, Luiza Wilges Kist, Gislaine Z. Réus, Emilio L. Streck

Publikováno v: Neurotoxicity research. 34(4)

Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in the activity of the enzyme tyrosine aminotransferase, leading to tyrosine accumulation in the body. Although the mechanisms involved are still poorly understood, several s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3a8bb419bb32b2e48a92335856630d
https://pubmed.ncbi.nlm.nih.gov/29417439

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Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes

Autor: Cenita Borges, Emilio L. Streck, Milena Carvalho-Silva, Amanda V. Steckert, Roger B. Varela, Gustavo Feier, Kelen Cechinel-Recco, Daniela V. Bavaresco, Lara M. Gomes, João Quevedo, Samira S. Valvassori

Publikováno v: Psychiatry research. 264

The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3e3cf7164e9a75767c90a50c29e0e6
https://pubmed.ncbi.nlm.nih.gov/29653348

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