Zobrazeno 1 - 10
of 218
pro vyhledávání: '"LANJING ZHANG"'
Autor:
Jun Li, Changcai He, Shihang Liu, Yuting Guo, Yuxiu Zhang, Lanjing Zhang, Xu Zhou, Dongyu Xu, Xu Luo, Hongying Liu, Xiaorong Yang, Yang Wang, Jun Shi, Bin Yang, Jing Wang, Pingrong Wang, Xiaojian Deng, Changhui Sun
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
In plants, carbohydrates are central products of photosynthesis. Rice is a staple that contributes to the daily calorie intake for over half of the world’s population. Hence, the primary objective of rice cultivation is to maximize carbohydrate pro
Externí odkaz:
https://doaj.org/article/021983c098284bdb96f2bb27f02091a0
Autor:
Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Jill Bargonetti, Lanjing Zhang, Ping Xie, Zhaohui Feng, Wenwei Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced gastrointestinal toxicity. However, its underlying mechanism remains un
Externí odkaz:
https://doaj.org/article/d8e4f15141f54dd99acfda452a096b3e
Autor:
Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li, Lanlan Shen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background Methylation of the p16 promoter resulting in epigenetic gene silencing—known as p16 epimutation—is frequently found in human colorectal cancer and is also common in normal-appearing colonic mucosa of aging individuals. Thus, t
Externí odkaz:
https://doaj.org/article/d10a6307bd33412e88191550ddc155f1
Autor:
Xuetian Yue, Jianming Wang, Chun-yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng, Wenwei Hu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-12 (2022)
Abstract LIF, a multifunctional cytokine, is frequently overexpressed in many types of solid tumors, including breast cancer, and plays an important role in promoting tumorigenesis. Currently, how LIF promotes tumorigenesis is not well-understood. Me
Externí odkaz:
https://doaj.org/article/4dc77dee9b85412693c02e040467e203
Autor:
Juan Liu, Cen Zhang, Dandan Xu, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Jie Liu, Lanjing Zhang, Bruce G. Haffty, Wei-Xing Zong, Wenwei Hu, Zhaohui Feng
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
The tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the gain-of-function (GOF) mechanism. Currently,
Externí odkaz:
https://doaj.org/article/8c84a225363441b089cecc2abbfd1824
Autor:
Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a dysregulated urea cycle is implicated in cancer development, the i
Externí odkaz:
https://doaj.org/article/e6e32c682ad14bdb96a55a2eddeab428
Impact of Oncotype DX testing on ER+ breast cancer treatment and survival in the first decade of use
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background The Oncotype DX breast recurrence score has been introduced more than a decade ago to aid physicians in determining the need for systemic adjuvant chemotherapy in patients with early-stage, estrogen receptor (ER)+, lymph node-nega
Externí odkaz:
https://doaj.org/article/ce14c3be86e64d86b39880e63f62860d
Autor:
Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M. Inclan-Rico, John J. Ponessa, Ping Xie, Lanjing Zhang, Mark C. Siracusa, Zhaohui Feng, Wenwei Hu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
P53 is a well-known tumour suppressor, however its role in intestinal type 2 immunity is currently unclear. Here authors report that during parasitic infections, p53 triggers tuft cell Ca2+ influx and IL-25 release, and shows a regulatory role for p5
Externí odkaz:
https://doaj.org/article/f9bfbce6c11f42c2bf999c334a0f4939
Autor:
Xiang‐Lin Tan, Jian‐Yu E, Yong Lin, Timothy R. Rebbeck, Shou‐En Lu, Mingyi Shang, William K. Kelly, Anthony D'Amico, Mark N. Stein, Lanjing Zhang, Thomas L. Jang, Isaac Yi Kim, Kitaw Demissie, Anna Ferrari, Grace Lu‐Yao
Publikováno v:
Cancer Medicine, Vol 9, Iss 7, Pp 2379-2389 (2020)
Abstract Background Pre‐clinical studies suggest that metformin and statins may delay prostate cancer (PCa) metastases; however, data in humans are limited. To the best of our knowledge, this is the first human study aimed to quantify the individua
Externí odkaz:
https://doaj.org/article/c2361380119f40b3a468055abbe17f57
Autor:
Xiao Zhang, Sheila Bandyopadhyay, Leandro Pires Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo Ferraris, Lanjing Zhang, Wenwei Hu, Edward M. Bonder, Pawel R. Kiela, Robert Coffey, Michael P. Verzi, Ivaylo I. Ivanov, Nan Gao
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo survival and clonogenicity of intestinal stem cells (ISCs) strictly required growth response
Externí odkaz:
https://doaj.org/article/189dbd4ee40c44db9e9826fb8779f883