Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects

Autor: Vardigan JD, Houghton AK, Lange HS, Adarayan ED, Pall PS, Ballard JE, Henze DA, Uslaner JM

Publikováno v: Journal of Pain Research, Vol Volume 11, Pp 735-741 (2018)

Joshua D Vardigan, Andrea K Houghton, Henry S Lange, Emily D Adarayan, Parul S Pall, Jeanine E Ballard, Darrell A Henze, Jason M Uslaner Merck Research Laboratories, West Point, PA, USA Introduction: The development of novel analgesics to treat acute

Externí odkaz: https://doaj.org/article/b9220698cd9341d19847e0c8bed9c28d

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy.

Autor: Skudlarek JW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cooke AJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mitchell HJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Babaoglu K; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shaw AW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tong L; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nomland AB; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Labroli M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Sha D; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mulhearn JJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu C; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li SW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Beshore DC; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hughes JME; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Jouffroy M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wang H; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Balibar CJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Painter RE; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shen P; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lange HS; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ishchenko A; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Chen YT; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Klein DJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tracy RW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Miller RR; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cabalu TD; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu Z; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scapin G; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hruza AW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Dzhekieva L; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bukhtiyarova M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Homsher MF; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xu M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bahnck-Teets C; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McKenney D; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Buevich AV; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Liu J; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhang LK; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Meng T; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kelly T; Merck & Co., Inc., Rahway, New Jersey 07065, United States., DiNunzio E; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Soisson S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cheng RKY; leadXpro AG, CH-5234 Villigen, Switzerland., Hennig M; leadXpro AG, CH-5234 Villigen, Switzerland., Raheem I; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Walker SS; Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15620-15675. Date of Electronic Publication: 2024 Aug 22.

Pharmacological Characterization of the Novel and Selective α 7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.

Autor: Wang X; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.) xiaohai_wang@merck.com., Daley C; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Gakhar V; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Lange HS; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Vardigan JD; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Pearson M; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Zhou X; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Warren L; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Miller CO; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Belden M; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Harvey AJ; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Grishin AA; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Coles CJ; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., O'Connor SM; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Thomson F; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Duffy JL; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Bell IM; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.)., Uslaner JM; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey (X.W., C.D., V.G., H.S.L., J.D.V., M.P., X.Z., L.W., C.O.M., M.B., F.T., J.L.D., I.M.B., J.M.U.) and Bionomics Limited, Thebarton, Australia (A.J.H., A.A.G., C.J.C., S.M.O.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 May; Vol. 373 (2), pp. 311-324. Date of Electronic Publication: 2020 Feb 24.

Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity.

Autor: Vardigan JD; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA., Lange HS; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA., Tye SJ; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA., Fox SV; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA., Smith SM; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA., Uslaner JM; Merck & Co., Inc., WP45-1114, 770 Sumneytown Pike, West Point, PA, 19486, USA. jason_uslaner@merck.com.

Publikováno v: Psychopharmacology [Psychopharmacology (Berl)] 2016 Jul; Vol. 233 (13), pp. 2441-50. Date of Electronic Publication: 2016 Apr 27.

Gonadotrophin-releasing hormone neurons in a photoperiodic songbird express fos and egr-1 protein after a single long day.

Autor: Saab SS; Department of Psychology, Emory University, Atlanta, GA 30322, USA. dmaney@emory.edu, Lange HS, Maney DL

Publikováno v: Journal of neuroendocrinology [J Neuroendocrinol] 2010 Mar; Vol. 22 (3), pp. 196-207. Date of Electronic Publication: 2010 Jan 07.