High- and low-affinity PEGylated hemoglobin-based oxygen carriers: Differential oxidative stress in a Guinea pig transfusion model

Autor: Francesca Fumagalli, Giuseppe Ristagno, Luca Ronda, Esra'a Alomari, Davide Olivari, Gianluca Paredi, Roberto Latini, Chris E. Cooper, Stefano Bettati, Marialaura Marchetti, Deborah Novelli, Andrea Mozzarelli, Brandon J. Reeder, Stefano Bruno

Publikováno v: Free Radical Biology & Medicine
Free radical biology & medicine 124 (2018): 299–310. doi:10.1016/j.freeradbiomed.2018.06.018
info:cnr-pdr/source/autori:Alomari E, Ronda L, Bruno S, Paredi G, Marchetti ML, Bettati S, Olivari D, Fumagalli F, Novelli D, Ristagno G, Latini R, Cooper CE, Reeder BJ, Mozzarelli A/titolo:High-and low-affinity PEGylated hemoglobin-based oxygen carriers: Differential oxidative stress in a Guinea pig transfusion model/doi:10.1016%2Fj.freeradbiomed.2018.06.018/rivista:Free radical biology & medicine/anno:2018/pagina_da:299/pagina_a:310/intervallo_pagine:299–310/volume:124

Hemoglobin-based oxygen carriers (HBOCs) are an investigational replacement for blood transfusions and are known to cause oxidative damage to tissues. To investigate the correlation between their oxygen binding properties and these detrimental effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9239f8501b395e8185e06c719d030dd9
http://europepmc.org/articles/PMC6191936

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide

Autor: Satoshi Fukuoka, Yani Kaconis, Anna Gries, Klaus Brandenburg, Manfred Rössle, Ruth Prassl, Lena Heinbockel, Thomas Gutsmann

Publikováno v: FEBS Open Bio 4, 432-440 (2014). doi:10.1016/j.fob.2014.04.008
FEBS Open Bio, Vol 4, Iss C, Pp 432-440 (2014)
FEBS Open Bio

Highlights • β2-GPI binds more strongly to negatively charged phospatidylserine than to bacterial lipopolysaccharides (LPS). • β2-GPI has only a moderate tendency to influence LPS-induced cytokine production in vitro. • β2-GPI reacts exother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b3647f6a4a7696864d6772def6b473

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide.

Autor: Gries A; Institute of Physiology, Medical University of Graz, Harrachgasse 21/V, 8010 Graz, Austria., Prassl R; Institute of Biophysics, Medical University of Graz, Schmiedlstr. 6, 8042 Graz, Austria., Fukuoka S; National Institute of Advanced Industrial Science and Technology AIST, Takamatsu, Japan., Rössle M; European Molecular Biology Laboratory, c/o DESY, D-22603 Hamburg, Germany., Kaconis Y; Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany., Heinbockel L; Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany., Gutsmann T; Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany., Brandenburg K; Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany.

Publikováno v: FEBS open bio [FEBS Open Bio] 2014 May 02; Vol. 4, pp. 432-40. Date of Electronic Publication: 2014 May 02 (Print Publication: 2014).