Zobrazeno 1 - 10 of 211 pro vyhledávání: '"LAK cell"'
1
Akademický článek
Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo
Autor: Jing Wu, Ren De Zhu, Guo Min Cao, Jun Cheng Du, Xin Liu, Liang Zhuo Diao, Zhao Yan Zhang, Yang Sheng Hu, Xin Hua Liu, Jing Bo Shi
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 817-831 (2022)
T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and
Externí odkaz: https://doaj.org/article/8e6f3328a987410eab423607807111ee
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2
Akademický článek
PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study
Autor: Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a simil
Externí odkaz: https://doaj.org/article/406c24e5b9104f00acdc1bc578a5b053
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3
Akademický článek
3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo
Autor: Xiaorong Fu, Ran Zhao, Goo Yoon, Jung-Hyun Shim, Bu Young Choi, Fanxiang Yin, Beibei Xu, Kyle Vaughn Laster, Kangdong Liu, Zigang Dong, Mee-Hyun Lee
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundSkin cancer is one of the most commonly diagnosed cancers worldwide. The 5-year survival rate of the most aggressive late-stage skin cancer ranges between 20 and 30%. Thus, the discovery and investigation of novel target therapeutic agents
Externí odkaz: https://doaj.org/article/5904eced933f4537ae619a32a502f211
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4
Akademický článek
Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase
Autor: Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang
Publikováno v: Journal of Ginseng Research, Vol 40, Iss 4, Pp 400-408 (2016)
Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serin
Externí odkaz: https://doaj.org/article/ddfc5253404a43d28fe635021948d1c9
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5
PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study
Autor: Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a simil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e674fa95a8d5417ed958ce20d8dee172
https://pubmed.ncbi.nlm.nih.gov/35135547
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6
Akademický článek
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7
TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia
Autor: Xunming Ji, Haiping Zhao, Zhen Tao, Ziping Han, Yinghao Luo, Yumin Luo, Zhibin Fan, Rongliang Wang
Publikováno v: Aging and Disease
T-LAK-cell-originated protein kinase (TOPK) is a newly identified member of the mitogen-activated protein kinase family. Our previous study has showed that TOPK has neuroprotective effects against cerebral ischemia-reperfusion injury. Here, we invest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f006b6e7c1df3a063db6c464dc11ef56
http://europepmc.org/articles/PMC5963345
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8
Akademický článek
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9
Akademický článek
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10
Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations
Autor: Tomohide Hayashi, Ryoi Tamura, Satoshi Kuroda, Yumiko Hayakawa, Masaki Koh, Michiya Sugimori
Publikováno v: Oncotarget
Glioblastoma resists chemoradiotherapy, then, recurs to be a fatal space-occupying lesion. The recurrence is caused by re-growing cell populations such as glioma stem cells (GSCs), suggesting that GSC populations should be targeted. This study addres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbc32d4f753e80a67fcd7cd7714f132
https://doi.org/10.18632/oncotarget.23077
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