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Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1

Autor: Wai Man, Melitta Schachner, Neha Kayastha, Li Cai, Ohyoon Kwon, Myungsik Yoo

Publikováno v: International Journal of Neuroscience. 132:483-489

Close Homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules. CHL1 gene is located on human chromosome 3 and has been linked to several pathologies, including 3p deletion syndrome, schizophrenia, and tumor growth and metastasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6117959296ba7323f7721020f28d123
https://doi.org/10.1080/00207454.2020.1822357

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Alternative Splicing of Nrcam Gene in Dorsal Root Ganglion Contributes to Neuropathic Pain

Autor: Corinna Lin, Lingli Liang, Shaogen Wu, Yuan Xiang Tao, Yun-Juan Chang

Publikováno v: J Pain

NrCAM, a neuronal cell adhesion molecule in the L1 family of the immunoglobulin superfamily, is subjected to extensively alternative splicing and involved in neural development and some disorders. The aim of this study was to explore the role of Nrca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9e07595f9239673cc94b52a8e239fa
https://doi.org/10.1016/j.jpain.2019.12.004

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Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B

Autor: Paul B. Manis, Young K. Truong, Michael R. Kasten, Melitta Schachner, Chelsea S. Sullivan, Sarah D. Wade, Patricia F. Maness, Cassandra Sweetman, Rebeccah Stewart, Vishwa Mohan

Publikováno v: J Neurosci

Dendritic spines in the developing mammalian neocortex are initially overproduced and then eliminated during adolescence to achieve appropriate levels of excitation in mature networks. We show here that the L1 family cell adhesion molecule Close Homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6056c26d1cbc84c4e7dc20ad0da45f1e
https://doi.org/10.1523/jneurosci.2984-18.2019

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Akademický článek

Insertion and/or Deletion of Many Repeated DNA Sequences in Human and Higher Ape Evolution

Autor: Hwu, Huey Ru, Roberts, John W., Davidson, Eric H., Britten, Roy J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1986 Jun 01. 83(11), 3875-3879.

Externí odkaz: https://www.jstor.org/stable/27790

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Akademický článek

A Large Interspersed Repeat Found in Mouse DNA Contains a Long Open Reading Frame That Evolves as If It Encodes a Protein

Autor: Martin, Sandra L., Voliva, Charles F., Burton, Frank H., Edgell, Marshall H., Hutchison, Clyde A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1984 Apr . 81(8), 2308-2312.

Externí odkaz: https://www.jstor.org/stable/23538

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Akademický článek

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Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization

Autor: Patricia F. Maness, Bryce W. Duncan, Kelsey E. Murphy

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abef0e7297c85e5da3eec695824a34d8
https://www.frontiersin.org/articles/10.3389/fcell.2021.625340/full

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An unfolding role for ankyrin-G at the axon initial segment

Autor: James L. Salzer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Axon initial segments of vertebrate neurons integrate thousands of dendritic inputs and generate a single outgoing action potential. Giant ankyrin-G associates with most of the molecular components of axon initial segments and is require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dbaade2666618e8dca2c91c2eb8727
https://doi.org/10.1073/pnas.1914002116

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L1 Retrotransposons Are Transcriptionally Active in Hippocampus of Rat Brain

Autor: Deepak Sharma, Kailash C. Upadhyaya, Somnath Mukherjee

Publikováno v: Prague Medical Report, Vol 117, Iss 1, Pp 42-53 (2016)

LINE1 (L1) is an autonomous, non-LTR retrotransposon and the L1 family of retrotransposons constitute around 17%, 20% and 23% in the human, mouse and rat genomes respectively. Under normal physiological conditions, the retroelements remain by and lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647bb0623372a73fe012a82c253013d8
https://doi.org/10.14712/23362936.2016.4

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