Early Intervention with Epoetin Alfa During Platinum-Based Chemotherapy: An Analysis of Quality-of-Life Results of a Multicenter, Randomized, Controlled Trial Compared with Population Normative Data

Autor: Cees J. van Groeningen, G. Giaccone, L.W. Wormhoudt, Jorine H. Savonije

Publikováno v: The Oncologist. 11:197-205

To evaluate the effect of epoetin alfa on quality of life (QOL) in patients with solid tumors and mild-to-moderate anemia receiving platinum-based chemotherapy relative to population norms.In the original study, patients (n = 316) with hemoglobin (Hb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ecccc9199a6da02fe7521c49c1886
https://doi.org/10.1634/theoncologist.11-2-197

The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide

Autor: P.J. van Bladeren, L.W. Wormhoudt, Jan N. M. Commandeur, J.H.T.M. Ploemen, I de Waziers, M. J. Oudshoorn, Philippe Beaune, Nico P. E. Vermeulen, Guido R. M. M. Haenen, T. Watabe

Publikováno v: Ploemen, J P H T M, Wormhoudt, L W, Haenen, G R M M, Oudshoorn, M J, Commandeur, J N M, Vermeulen, N P E, De Waziers, I, Beaune, P H, Watabe, T & van Bladeren, P J 1997, ' The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide. ', Toxicology and Applied Pharmacology, vol. 143, pp. 56-69 . https://doi.org/10.1006/taap.1996.8004
Toxicology and Applied Pharmacology, 143, 56-69
Toxicology and Applied Pharmacology, 143, 56-69. Academic Press Inc.
Toxicology and Applied Pharmacology 143 (1997)

Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S -transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60055c883c300fa9084d2934522198
https://hdl.handle.net/1871/24904

Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats

Autor: P.J. van Bladeren, J.H.T.M. Ploemen, Nico P. E. Vermeulen, Jan N. M. Commandeur, L.W. Wormhoudt, B. van Ommen

Publikováno v: Chemico-Biological Interactions, 99, 41-53. Elsevier Ireland Ltd
Wormhoudt, L W, Ploemen, J P H T M, Commandeur, J N M, van Ommen, B, van Bladeren, P J & Vermeulen, N P E 1996, ' Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats. ', Chemico-Biological Interactions, vol. 99, pp. 41-53 . https://doi.org/10.1016/0009-2797(95)03659-8

The cytochrome P450 (P450) catalyzed oxidation of 1,2-dibromoethane (1,2-DBE) to 2-bromoacetaldehyde (2-BA) was measured in liver microsomes of both control and differentially induced rats. 2-BA formation was quantified by derivatization of 2-BA with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e757defc484396a4e5d7ddb636562
https://hdl.handle.net/1871/25254

Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it

Autor: L.W. Wormhoudt, Q.J Li, S Ramnatshing, Nico P. E. Vermeulen, E.J. Groot, J. P. G. Brakenhoff, Jan N. M. Commandeur

Publikováno v: Chemico-Biological Interactions, 110, 139-158. Elsevier Ireland Ltd
Vrije Universiteit Amsterdam
Chemico-Biological Interactions, 110(3), 139-58. Elsevier Ireland Ltd
Vermeulen, N P, Commandeur, J N, Groot, E J, Wormhoudt, L W, Ramnatshing, S, Li, Q J & Brakenhoff, J P 1998, ' Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it ', Chemico-Biological Interactions, vol. 110, no. 3, pp. 139-58 . https://doi.org/10.1016/S0009-2797(98)00004-0
Vermeulen, N P E, Commandeur, J N M, Groot, E J, Wormhoudt, L W, Ramnathsing, S, Li, Q J & Brakenhoff, J P G 1998, ' Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it. ', Chemico-Biological Interactions, vol. 110, pp. 139-158 . https://doi.org/10.1016/S0009-2797(98)00004-0

Fotemustine is a relatively novel DNA-alkylating 2-chloroethyl-substituted N-nitrosourea (CENU) drug, clinically used for the treatment of disseminated malignant melanoma in different visceral and non-visceral tissues. Thrombocytopenia has been obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400d9c813a5c8e84696c89ad1af9cd64
https://research.vu.nl/en/publications/03fbe49f-c862-40d1-848a-e14fa9c13e8a

In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate

Autor: P.J. van Bladeren, Nico P. E. Vermeulen, M. van Iersel, Jan N. M. Commandeur, J.H.T.M. Ploemen, L.W. Wormhoudt

Publikováno v: Ploemen, J P H T M, van Iersel, M, Wormhoudt, L W, Commandeur, J N M, Vermeulen, N P E & van Bladeren, P J 1996, ' In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate. ', Biochemical Pharmacology, vol. 52, pp. 197-204 . https://doi.org/10.1016/0006-2952(96)00142-6
Biochemical Pharmacology 52 (1996)
Biochemical Pharmacology, 52, 197-204
Biochemical Pharmacology, 2, 52, 197-204
Biochemical Pharmacology, 52, 197-204. Elsevier Inc.

The drug disulfiram (DSF, Antabuse) has been used in the therapy of alcohol abuse. It is a potent inhibitor of aldehyde dehydrogenase. Its reduced form, diethyldithiocarbamate (DDTC), and further metabolites show similar activities. DSF and DDTC have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1019d53dec0451bc9dd5ff4571a6233
https://research.vu.nl/en/publications/db901fc4-3409-471c-967d-6d4b148ab51a