Zobrazeno 1 - 10
of 81
pro vyhledávání: '"L.P.A. de Jong"'
Publikováno v:
Journal of Analytical Toxicology. 28:311-315
A procedure for the modified Edman degradation of globin for determination of sulfur mustard adducts to the N-terminal valine residue in human hemoglobin has been developed for use under field laboratory conditions. The minimum detectable exposure le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfefe091b829170e30e81fd71b7e323
https://doi.org/10.1093/jat/28.5.311
https://doi.org/10.1093/jat/28.5.311
Autor:
Helma E.T. Spruit, Jan P. Langenberg, Hendrik P. Benschop, H.J. van der Wiel, L.P.A. de Jong, Henk C. Trap
Publikováno v:
Toxicology and Applied Pharmacology. 153:179-185
In order to initiate a quantitative basis for the toxicology of low level exposure to nerve agents, the toxicokinetics of soman stereoisomers during nose-only exposure for 5 h to 20 ppb (160 microg/m3) of C(+/-)P(+/-)-soman in air were studied in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d72fb50ee08dbf845765b46a9aea80
https://doi.org/10.1006/taap.1998.8490
https://doi.org/10.1006/taap.1998.8490
Autor:
L.P.A. de Jong, Hendrik P. Benschop, Anne H. Due, Henk C. Trap, C. Van Dijk, H. P. M. Van Helden, H.J. van der Wiel
Publikováno v:
Life Sciences. 50:1057-1062
Concentrations of C(+/-)P(+/-)-soman (1,2,2-trimethylpropyl methylphosphonofluoridate) in urine of anaesthetized, atropinized and artificially ventilated rats, guinea pigs and marmosets were determined 1-4 h after iv administration of 1-6 LD50 of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fa0ecc054749f3975e0baddce7a00b
https://doi.org/10.1016/0024-3205(92)90101-t
https://doi.org/10.1016/0024-3205(92)90101-t
Autor:
L.P.A. de Jong, Daan Noort, Roos H. Mars-Groenendijk, G.P. van der Schans, Hendrik P. Benschop
Publikováno v:
Journal of analytical toxicology. 28(5)
A standard operating procedure has been developed for an immunoslotblot assay of sulfur mustard adducts to DNA in human blood and skin for use in a field laboratory. A minimum detectable level of exposure of human blood in vitro (> or = 50 nM) sulfur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a62294fbb5f7dae418a5545fea3246a
https://pubmed.ncbi.nlm.nih.gov/15239849
https://pubmed.ncbi.nlm.nih.gov/15239849
Publikováno v:
Archives of Toxicology, 4-5, 74, 207-214
The development of a procedure for retrospective detection and quantitation of exposure to the arsenical dichloro(2-chlorovinyl)arsine (lewisite; L1) has been initiated. Upon incubation of human blood with [14C]L1 (20 nM-0.2 mM) in vitro, more than 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a85fb92f5d0c3b1af3def53be76d1e
https://pubmed.ncbi.nlm.nih.gov/10959794
https://pubmed.ncbi.nlm.nih.gov/10959794
Publikováno v:
Chemical Research in Toxicology, 8, 13, 719-726
The development of procedures for retrospective detection and quantitation of exposure to phosgene, based on adducts to hemoglobin and albumin, is described. Upon incubation of human blood with [(14)C]phosgene (0-750 microM), a significant part of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccf57d738920a2e8e6721f436b61c21
https://pubmed.ncbi.nlm.nih.gov/10956059
https://pubmed.ncbi.nlm.nih.gov/10956059
Publikováno v:
Chemical research in toxicology. 12(8)
To develop a mass spectrometric assay for the detection of sulfur mustard adducts with human serum albumin, the following steps were performed: quantitation of the binding of the agent to the protein by using [(14)C]sulfur mustard and analysis of aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaf478d779c8bcad65714d13ac91cf6
https://pubmed.ncbi.nlm.nih.gov/10458705
https://pubmed.ncbi.nlm.nih.gov/10458705
Autor:
Hendrik P. Benschop, C. Van Dijk, Richard E. Sweeney, Jan P. Langenberg, L.P.A. de Jong, Donald M. Maxwell
Publikováno v:
Archives of toxicology. 71(5)
A physiologically based model was developed which describes the in vivo toxicokinetics of the highly reactive nerve agent C(+/-)P(+/-)-soman at doses corresponding to 0.8-6 LD50 in the atropinized guinea pig. The model differentiates between the summ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3132e9176313676122ced361452ba46
https://pubmed.ncbi.nlm.nih.gov/9137811
https://pubmed.ncbi.nlm.nih.gov/9137811
Publikováno v:
Chemical Research in Toxicology, 4, 9, 781-787
In this paper we describe the use of tandem mass spectrometry to identify modified sites in human hemoglobin after in vitro exposure to bis(2-chloroethyl) sulfide (sulfur mustard). Globin isolated from human whole blood which had been exposed to sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7564c06a8a7e25bd82b7129e21b4c2
http://resolver.tudelft.nl/uuid:31705c80-5e63-48b3-a08e-421db1282576
http://resolver.tudelft.nl/uuid:31705c80-5e63-48b3-a08e-421db1282576
Publikováno v:
Archives of toxicology. 70(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2447836226a28b073d8aa6f1db5841fa
https://pubmed.ncbi.nlm.nih.gov/8911645
https://pubmed.ncbi.nlm.nih.gov/8911645