Výsledky vyhledávání

The rational design of TAP inhibitors using peptide substrate modifications and peptidomimetics

Autor: Jacques Neefjes, K. Sliedregt, G. J. Hämmerling, Frank Momburg, Monique Grommé, L.N. Vernie, Jens-Oliver Koopmann, Rob M. J. Liskamp, R. van der Valk

Publikováno v: European Journal of Immunology. 27:898-904

The major histocompatibility complex (MHC)-encoded transporter associated with antigen processing (TAP) translocates peptides from the cytosol into the lumen of the endoplasmic reticulum. This step precedes the binding of peptides to MHC class I mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb347004fc98737514dfc6b6b466ece9
https://doi.org/10.1002/eji.1830270415

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Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules

Autor: Stanley G. Nathenson, Ton N. Schumacher, Hidde L. Ploegh, Grada M. van Bleek, Mónica Imarai, Marie Therese Heemels, Ka Wan Li, Karl Deres, L.N. Vernie

Publikováno v: European Journal of Immunology. 22:1405-1412

Major histocompatibility complex (MHC) class I molecules combine with short peptides of defined length and sequence. Here we describe an approach that may be used in the analysis of peptide preference of different allelic MHC class I molecules, and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bde739030ac829cc8b7113db7b9b76
https://doi.org/10.1002/eji.1830220612

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Peptide selection by MHC class I molecules

Autor: Marloes L. H. De Bruijn, Jacques Neefjes, W. Martin Kast, Cornelis J. M. Melief, L.N. Vernie, Ton N. Schumacher, Hidde L. Ploegh

Publikováno v: Nature. 350:703-706

SYNTHETIC peptides have been used to sensitize target cells and thereby screen for epitopes recognized by T cells1–7. Most epitopes of cytotoxic T lymphocytes can be mimicked by synthetic peptides of 12–15 amino acids8. Although in specific cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7836f606e758409f21428b05c5f7aca6
https://doi.org/10.1038/350703a0

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Selenium in carcinogenesis

Autor: L.N. Vernie

Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 738:203-217

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35760bed75fee6373e449f413d2114b7
https://doi.org/10.1016/0304-419x(83)90004-5

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Elongation factor 2 as the target of the reaction product between sodium selenite and glutathione (GSSeSG) in the inhibiting of amino acid incorporation in vitro

Autor: H.B. Ginjaar, P. Emmelot, L.N. Vernie, Willy S. Bont

Publikováno v: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 414:283-292

The product of the reaction between sodium selenite and glutathione, designated as selenodiglutathione (GSSeSG), nearly completely inhibits amino acid incorporation from [ 14 C]leucyl-tRNA by free polyribosomes isolated from rat liver. The mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c9aaa773facda181c69302edf2d620
https://doi.org/10.1016/0005-2787(75)90167-7

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Inhibition of the growth of malignant mouse lymphoid cells by selenodiglutathione and selenodicysteine

Autor: W.S. Bont, C.J. Homburg, L.N. Vernie

Publikováno v: Cancer Letters. 14:303-308

Intraperitoneal injections of selenodiglutathione (GSSeSG) or selenodicysteine (CySSeSCy) in mice, previously inoculated with tumor cells, inhibited tumor growth and increased the life span of treated as compared with untreated control mice. Determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e74ffcf04e09e21d3a79045db9449cf6
https://doi.org/10.1016/0304-3835(81)90159-2

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Selenium levels in blood and plasma, and glutathione peroxidase activity in blood of breast cancer patients during adjuvant treatment with cyclophosphamide, methotrexate and 5-fluorouracil

Autor: C. Benckhuijsen, L.N. Vernie, M. De Vries, J. J. M. de Goeij, C. Zegers

Publikováno v: Cancer Letters. 18:283-289

Glutathione peroxidase activity in whole blood and selenium levels in whole blood and plasma from breast cancer patients, were measured during combination chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil. No significant change in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a076b878e49d33e03ec2cde6d5e4d07
https://doi.org/10.1016/0304-3835(83)90237-9

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