Výsledky vyhledávání - "L.M.L. van Winsen"

Glucocorticoid receptor gene polymorphisms associated with more aggressive disease phenotype in MS

Autor: L.M.L. van Winsen, T. Hooper-van Veen, B.M.J. Uitdehaag, E.F.C. van Rossum, Chris H. Polman, Jan W. Koper, Frederik Barkhof

Publikováno v: Journal of Neuroimmunology, 186(1-2), 150-155. Elsevier

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, in which unknown environmental factors are thought to trigger disease in genetically susceptible persons. Glucocorticoids (GCs) play an importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36969c5760b2a76e73387b0f9489e1e8
https://doi.org/10.1016/j.jneuroim.2007.02.006

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Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression

Autor: Frederik Barkhof, L.M.L. van Winsen, Madeleine H. Sombekke, Chris H. Polman, Marinus A. Blankenstein, Christine D. Dijkstra, Charlotte E. Teunissen, Joep Killestein, D. Pratico

Publikováno v: Multiple Sclerosis, 18(8), 1092-1098. SAGE Publications Ltd
Teunissen, C E, Sombekke, M H, van Winsen, L, Killestein, J, Barkhof, F, Polman, C H, Dijkstra, C D, Blankenstein, M A & Pratico, D 2012, ' Increased plasma 8,12-iso-iPF2alpha-VI levels in relapsing multiple sclerosis patients are not predictive of disease progression ', Multiple Sclerosis, vol. 18, no. 8, pp. 1092-1098 . https://doi.org/10.1177/1352458511433306

Background: Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression. Objective: To study whether plasma isoprostane levels were re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b55e9c8701da92bb30452fe429131
https://pubmed.ncbi.nlm.nih.gov/22695538

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[Alpha]B-crystallin genotype has impact on the multiple sclerosis phenotype

Autor: Chris H. Polman, L.M.L. van Winsen, B.M.J. Uitdehaag, Aránzazu Peña, J.B.A. Crusius, F. Barkhof, N. F. Kalkers, T. van Veen

Publikováno v: Neurology. 61(9)

Background: Both multiple sclerosis (MS) susceptibility and MS clinical phenotype are in part genetically determined. αB-Crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene ( CRY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77520e6cbaf07c0f39b2670df810d925
https://pubmed.ncbi.nlm.nih.gov/14610128

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The FAS-670 polymorphism influences susceptibility to multiple sclerosis

Autor: N. F. Kalkers, L.M.L. van Winsen, Peter Joseph Jongen, Frederik Barkhof, T. van Veen, B.M.J. Uitdehaag, Amado Salvador Peña, J.B.A. Crusius, Chris H. Polman

Publikováno v: Journal of neuroimmunology. 128(1-2)

Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS 670 polymorphism in 382 patients with MS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df3dbeeafd39a72d8ca046637c5530
https://pubmed.ncbi.nlm.nih.gov/12098516

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Comparisons of patient self-report, neurologic examination, and functional impairment in MS

Autor: L.M.L. van Winsen, N.F. Kalkers, Chris H. Polman, E.L.J. Hoogervorst, M.J. Eikelenboom, B.M.J. Uitdehaag

Publikováno v: Neurology. 56(7)

Objective: To compare the recently developed Guy’s Neurologic Disability Scale (GNDS), based on patient self-report, with both neurologist rating of neurologic examination abnormalities using the Expanded Disability Status Scale (EDSS) and observat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f75af1221746b5c36d5be710c6fc258
https://pubmed.ncbi.nlm.nih.gov/11294932

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