Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infectionResearch in context

Autor: Lihui Guo, Brent Appelman, Kirsten Mooij-Kalverda, Riekelt H. Houtkooper, Michel van Weeghel, Frédéric M. Vaz, Annemiek Dijkhuis, Tamara Dekker, Barbara S. Smids, Jan Willem Duitman, Marianna Bugiani, Paul Brinkman, Jonne J. Sikkens, H.A. Ayesha Lavell, Rob C.I. Wüst, Michèle van Vugt, René Lutter, M.A. van Agtmael, A.G. Algera, B. Appelman, F.E.H.P. van Baarle, M. Beudel, H.J. Bogaard, M. Bomers, P.I. Bonta, L.D.J. Bos, M. Botta, J. de Brabander, G.J. de Bree, S. de Bruin, M. Bugiani, E.B. Bulle, O. Chouchane, A.P.M. Cloherty, D. Buis, M.C.F.J. de Rotte, M. Dijkstra, D.A. Dongelmans, R.W.G. Dujardin, P.E. Elbers, L.M. Fleuren, S.E. Geerlings, T.B.H. Geijtenbeek, A.R.J. Girbes, A. Goorhuis, M.P. Grobusch, L.A. Hagens, J. Hamann, V.C. Harris, R. Hemke, S.M. Hermans, L.M.A. Heunks, M.W. Hollmann, J. Horn, J.W. Hovius, M.D. de Jong, R. Koing, E.H.T. Lim, N. van Mourik, J.F. Nellen, E.J. Nossent, F. Paulus, E. Peters, D. Piña-Fuentes, T. van der Poll, B. Preckel, J.M. Prins, S.J. Raasveld, T.D.Y. Reijnders, M. Schinkel, F.A.P. Schrauwen, M.J. Schultz, A.R. Schuurman, J. Schuurmans, K. Sigaloff, M.A. Slim, P. Smeele, M.R. Smit, C. Stijnis, W. Stilma, C.E. Teunissen, P. Thoral, A.M. Tsonas, P.R. Tuinman, M. van der Valk, D.P. Veelo, C. Volleman, H. de Vries, L.A. van Vught, M. van Vugt, D. Wouters, A.H. Zwinderman, M.C. Brouwer, W.J. Wiersinga, A.P.J. Vlaar, D. van de Beek

Publikováno v: EBioMedicine, Vol 94, Iss , Pp 104729- (2023)

Summary: Background: Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/seve

Externí odkaz: https://doaj.org/article/d01232b4f65044ae908001bceb0907e4

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Sustained Alveolar Hyperinflammatory Response in Critically Ill COVID-19 Patients

Autor: L.S. Boers, J. De Brabander, E.J. Nossent, L.M.A. Heunks, A.P.J. Vlaar, P.I. Bonta, T. van der Poll, J. Duitman, L.D.J. Bos, null ArtDECO consortium, null Amsterdam UMC COVID study group

Publikováno v: B104. COVID ACROSS THE CARE CONTINUUM.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce8c7e9e3a4f2b82684b6749face5345
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3539

Lung- and Diaphragm-Protective Ventilation

Autor: Robinder G. Khemani, Eddy Fan, Samir Jaber, Giacomo Grasselli, Alexandre Demoule, Sarina K. Sahetya, Jose Dianti, Dimitrios Georgopoulos, Francesco Mojoli, Tommaso Mauri, Laurent Brochard, Katerina Vaporidi, Claude Guérin, Coen A.C. Ottenheijm, Jeremy R. Beitler, Tom Schepens, Savino Spadaro, Takeshi Yoshida, Antonio Pesenti, Franco Laghi, Marcelo B. P. Amato, Ewan C. Goligher, Alain Mercat, Domenico Luca Grieco, Giacomo Bellani, L.M.A. Heunks, Irene Telias, Niall D. Ferguson, Martin Dres, Jordi Mancebo, Bhakti K. Patel

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 202(7), 950-961. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2020, 202 (7), pp.950-961. ⟨10.1164/rccm.202003-0655CP⟩
Goligher, E C, Dres, M, Patel, B K, Sahetya, S K, Beitler, J R, Telias, I, Yoshida, T, Vaporidi, K, Grieco, D L, Schepens, T, Grasselli, G, Spadaro, S, Dianti, J, Amato, M, Bellani, G, Demoule, A, Fan, E, Ferguson, N D, Georgopoulos, D, Guérin, C, Khemani, R G, Laghi, F, Mercat, A, Mojoli, F, Ottenheijm, C A C, Jaber, S, Heunks, L M A, Mancebo, J, Mauri, T, Pesenti, A & Brochard, L 2020, ' Lung-and Diaphragm-Protective Ventilation ', American Journal of Respiratory and Critical Care Medicine, vol. 202, no. 7, pp. 950-961 . https://doi.org/10.1164/rccm.202003-0655CP
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 202 (7), ⟨10.1164/rccm.202003-0655CP⟩
Am J Respir Crit Care Med
American journal of respiratory and critical care medicine
American Journal of Respiratory and Critical Care Medicine, 2020, 202 (7), ⟨10.1164/rccm.202003-0655CP⟩

International audience; Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated with poor clinical outcomes. Although the importance and impact of lung-protective ventilation is widely appreciated and well establis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f186216e6c5892b53429f49e8eb9ab0
http://hdl.handle.net/11392/2471255

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