Zobrazeno 1 - 10
of 158
pro vyhledávání: '"L.M. van Putten"'
Publikováno v:
European Journal of Cancer (1965). 15:1139-1149
It had been shown previously that treatment of mice with cyclophosphamide before i.v. inoculation of tumour cells enhanced the growth of lung colonies. Results presented here show that treatment with cyclophosphamide after i.v. inoculation of tumour
Autor:
P. Lelieveld, L.M. van Putten, D. van Velzen, Ghanem Atassi, W.J.F. van der Vijgh, André Danguy, Roel W. Veldhuizen
Publikováno v:
European Journal of Cancer and Clinical Oncology. 20:1087-1104
Preclinical studies were performed in mice, rats and dogs of cis-diamminedichloroplatinum(II) (CDDP) and its derivatives cis-1,1-di(aminomethyl) cyclohexane platinum(II) sulphate (TNO-6), cis-diammine-1,1-cyclobutanedicarboxylate platinum(II) (CBDCA)
Publikováno v:
European Journal of Cancer and Clinical Oncology. 18:281-289
Spontaneous metastases in lymph nodes and/or the lung were obtained after tumour cell inoculation of four mouse tumours and one rat tumour into the foot-pads of syngeneic animals or their F1 hybrids. Following local radiotherapy with doses of 45–80
Publikováno v:
European Journal of Cancer (1965). 13:1123-1131
The effect of combination chemotherapy with CCNU and 5 -FU given either simultaneously or with a time interval of 24 hr was studied in the Lewis lung carcinoma and in the mouse osteosarcoma C 22 LR. Tumour growth delay, number of lung metastases and
Publikováno v:
European Journal of Cancer (1965). 11:169-173
In a comparative study the effect of six hexitol derivatives, mannitol mustard, dibromomannitol, dianhydromannitol, dibromodulcitol, dianhydrodulcitol and dimesyldianhydroiditol (DMDAI) on haematopoietic stem cells was studied by the spleen colony te
Autor:
L.M. Van Putten
Publikováno v:
European Journal of Cancer (1965). 16:173-176
(b) the logari thm of the factor, by which the number of cells is reduced (log kill) by a drug, is proport ional to the dose of the drug used. This model was assumed valid also for solid tumours with a number of restrictions which were not quant i ta
Publikováno v:
European Journal of Cancer (1965). 10:667-671
By a comparison of in vitro and in vivo effectiveness of cytostatic agents on a transplantable mouse osteosarcoma, a number of drugs were identified for which the in vitro response is not a good prediction for the in vivo response. For a number of su
Publikováno v:
European Journal of Cancer and Clinical Oncology. 22:265-272
For early passages of 15 human tumours grown in nude mice two types of test for prediction of sensitivity to cytostatic drugs were carried out for four platinum compounds. The subrenal capsule assay of Bogden was not found to be useful for these earl
Autor:
L.M. van Putten
Publikováno v:
Cancer Treatment Reviews. 11:19-23
The basis for combination chemotherapy is not the carefully premeditated interaction of multiple agents which can sometimes be demonstrated to be of benefit in the somewhat artificial mouse tumour systems. The real basis is the uncertainty concerning
Publikováno v:
European Journal of Cancer and Clinical Oncology. 20:1549-1556
Cyclophosphamide (CY) prevented the host response from occurring in treated animals, and we therefore evaluated CY and other immunosuppressive forms of pretreatment in normal mice using the subrenal capsule assay initially for transplanted and later