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Influence of Kv11.1 (hERG1) K+ channel expression on DNA damage induced by the genotoxic agent methyl methanesulfonate

Autor: Sara Fernández-Villabrille, Enol Álvarez-González, Pilar de la Peña, Francisco Barros, L.M. Sierra

Publikováno v: Pflügers Archiv - European Journal of Physiology. 473:197-217

Besides their crucial role in cell electrogenesis and maintenance of basal membrane potential, the voltage-dependent K+ channel Kv11.1/hERG1 shows an essential impact in cell proliferation and other processes linked to the maintenance of tumour pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84d2bb508221c7d5ed864f55ba182ef8
https://doi.org/10.1007/s00424-021-02517-2

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Targeting HER2 protein in individual cells using ICP-MS detection and its potential as prognostic and predictive breast cancer biomarker

Autor: L.M. Sierra, Jörg Bettmer, E. Blanco González, Mario Corte-Rodríguez, A. Fernández Asensio, Maria Montes-Bayón

Publikováno v: Talanta. 235

The human epidermal growth factor receptor 2 (HER2) is a transmembrane protein that has become one of the most specific prognostic and predictive biomarker of breast cancer. Its early detection is key for optimizing the patient clinical outcome. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf28107fe53beff85b2622892d0d732
https://pubmed.ncbi.nlm.nih.gov/34517630

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The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

Autor: Pedro Domínguez, Francisco Barros, Luis A. Pardo, L.M. Sierra, Pilar de la Peña

Publikováno v: Frontiers in Pharmacology
Scopus
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Front Pharmacol
Frontiers in Pharmacology, Vol 11 (2020)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

EAG (ether-a-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b8ae093be4d8d377113d5f3111a34a
http://europepmc.org/articles/PMC7174612

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Multiplex polymerase chain reaction in combination with gel electrophoresis-inductively coupled plasma mass spectrometry: A powerful tool for the determination of gene copy number variations and gene expression changes

Autor: Elisa Blanco-González, Tamara Iglesias, L.M. Sierra, M. Espina, A. Cotarelo, A. Fernández Asensio, Maria Montes-Bayón

Publikováno v: Analytica Chimica Acta. 1023:64-73

During the last few years multiplex real-time or quantitative polymerase chain reaction PCR (qPCR) has become the method of choice for multiplex gene expression changes and gene copy number variations (CNVs) analysis. However, such determinations req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5fc8e326ec74aee307899246259e9e
https://doi.org/10.1016/j.aca.2018.03.047

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Chromatographic methods coupled to mass spectrometry for the determination of oncometabolites in biological samples-A review

Autor: E. Alvarez-González, L.M. Sierra, A. Fernández Asensio, Elisa Blanco-González, A. Rodríguez

Publikováno v: Analytica Chimica Acta. 1177:338646

It is now well-established that dysregulation of the tricarboxylic acid (TCA) cycle enzymes succinate dehydrogenase, fumarate hydratase, and isocitrate dehydrogenase leads to the abnormal cellular accumulation of succinate, fumarate, and 2-hydroxyglu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fd89e336915e679518925ead260f98
https://doi.org/10.1016/j.aca.2021.338646

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Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection

Autor: Elisa Blanco-González, A. Fernández Asensio, Maria Montes-Bayón, L.M. Sierra

Publikováno v: Analytica chimica acta. 1090

Sensitive and selective analytical methods are necessary for the determination of clinical biomarkers of breast cancer. The human epidermal growth factor receptor 2 (HER2) is an important breast cancer biomarker since tumors with HER2 protein overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc76da1cf6e57fc27e27e489cec5a9a
https://pubmed.ncbi.nlm.nih.gov/31655644

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