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Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family

Autor: Bärbel S. Blaum, W. Ian Lipkin, L.J. Stroh, Thilo Stehle, Nischay Mishra, Philip Rößler, N.H. Rustmeier, Josephine Botsch, Florian Wedekink

Publikováno v: mBio
mBio, Vol 11, Iss 4 (2020)

Virus attachment to cell surface receptors is critical for productive infection. In this study, we have used a structure-based approach to investigate the cell surface recognition event for New Jersey polyomavirus (NJPyV) and human polyomavirus 12 (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f5dbe0372f436dcc6a7ebb80943a09
http://europepmc.org/articles/PMC7387793

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The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity

Autor: Christian D. S. Nelson, Gretchen V. Gee, Melissa S. Maginnis, Walter J. Atwood, Thilo Stehle, Nasim Motamedi, Ursula Neu, Bethany A. O'Hara, Daniel DiMaio, Bärbel S. Blaum, L.J. Stroh

Publikováno v: Journal of Virology. 89:6364-6375

The human JC polyomavirus (JCPyV) establishes an asymptomatic, persistent infection in the kidneys of the majority of the population and is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b58bb64bd14b86c5dafb7e0dd20ab
https://doi.org/10.1128/jvi.00489-15

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Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins

Autor: Christian D. S. Nelson, Walter J. Atwood, L.J. Stroh, Gretchen V. Gee, Bethany A. O'Hara, Thilo Stehle

Publikováno v: Journal of Virology. 89:3910-3921

JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a817b66b3ef60f4bf3eeea09b28d1b7
https://doi.org/10.1128/jvi.00089-15

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Glycan Engagement by Viruses: Receptor Switches and Specificity

Autor: L.J. Stroh, Thilo Stehle

Publikováno v: Annual Review of Virology. 1:285-306

A large number of viruses, including many human pathogens, bind cell-surface glycans during the initial steps of infection. Viral glycan receptors such as glycosaminoglycans and sialic acid–containing carbohydrates are often negatively charged, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43bfac5185d3a34f98599af368bc877
https://doi.org/10.1146/annurev-virology-031413-085417

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Structure Analysis of the Major Capsid Proteins of Human Polyomaviruses 6 and 7 Reveals an Obstructed Sialic Acid Binding Site

Autor: Ursula Neu, L.J. Stroh, Thilo Stehle, Michael H. C. Buch, Bärbel S. Blaum, Robert L. Garcea

Publikováno v: Journal of Virology. 88:10831-10839

Human polyomavirus 6 (HPyV6) and HPyV7 are commonly found on human skin. We have determined the X-ray structures of their major capsid protein, VP1, at resolutions of 1.8 and 1.7 Å, respectively. In polyomaviruses, VP1 commonly determines antigenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad297fef85fd93215438f49f0012970
https://doi.org/10.1128/jvi.01084-14

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The Archaeal Proteasome Is Regulated by a Network of AAA ATPases

Autor: L.J. Stroh, Nicole Sessler, Cédric F.V. Hobel, Jörg Martin, Andrei N. Lupas, Dara Forouzan, Moritz Ammelburg

Publikováno v: The Journal of Biological Chemistry

Background: The AAA ATPases of the PAN/Rpt1–6 group regulate access of substrates to the 20S proteasome. Results: Two groups of AAA proteins, CDC48 and AMA, function as novel proteasomal ATPases in archaea. Conclusion: This network of regulatory AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db13af99e6a5f2e04e35c29468ed7b8
https://doi.org/10.1074/jbc.m112.386458

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Broadly neutralizing human monoclonal JC polyomavirus VP1–specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy

Autor: Mireia Sospedra, Jan Grimm, Roland Martin, L.J. Stroh, Ilijas Jelcic, Wolfgang Faigle, Luzia Senn, Benoit Combaluzier, Ivan Jelcic, Thilo Stehle, Brenda J. Reinhart, Roger M. Nitsch

Publikováno v: Science Translational Medicine. 7

In immunocompromised individuals, JC polyomavirus (JCPyV) may mutate and gain access to the central nervous system resulting in progressive multifocal leukoencephalopathy (PML), an often fatal opportunistic infection for which no treatments are curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6980856619135fd8bd5e695cb9425e7
https://doi.org/10.1126/scitranslmed.aac8691

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Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids

Autor: Aisling S. Dugan, Walter J. Atwood, Bärbel S. Blaum, L.J. Stroh, Mariet C.W. Feltkamp, Thilo Stehle, Gretchen V. Gee

Publikováno v: PLoS Pathogens
PLoS Pathogens, 11(8)
PLoS Pathogens, Vol 11, Iss 8, p e1005112 (2015)

Trichodysplasia spinulosa-associated Polyomavirus (TSPyV) was isolated from a patient suffering from trichodysplasia spinulosa, a skin disease that can appear in severely immunocompromised patients. While TSPyV is one of the five members of the polyo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b646680fe441489a61677706defde1e
https://hdl.handle.net/1887/105257

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Progressive Multifocal Leukoencephalopathy-Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding

Autor: Aaron Derdowski, L.J. Stroh, Gretchen V. Gee, Melissa S. Maginnis, Thilo Stehle, Bethany A. O'Hara, Walter J. Atwood

Publikováno v: mBio
mBio, Vol 4, Iss 3 (2013)

The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). The Mad-1 prototype strain of JCPyV uses the glycan lactoseries tetrasaccharide c (LSTc) and serotonin rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e5d529d11e9b4ae3e4545a576c1e5d
https://doi.org/10.1128/mbio.00247-13

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A structure-guided mutation in the major capsid protein retargets BK polyomavirus

Autor: Ursula Neu, L.J. Stroh, Ten Feizi, Thomas Peters, Yan Liu, Martin Frank, Thilo Stehle, Walter J. Atwood, Angelina S. Palma, Stacy Ann A. Allen, Bärbel S. Blaum

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003688 (2013)
PLoS Pathogens

Viruses within a family often vary in their cellular tropism and pathogenicity. In many cases, these variations are due to viruses switching their specificity from one cell surface receptor to another. The structural requirements that underlie such r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bab77b78707f20ef63f8612b7e0e9a
http://europepmc.org/articles/PMC3795024?pdf=render

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