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Monoclonal antibodies to the leukocyte membrane CD18 glycoprotein complex and to intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits

Autor: Robert Rothlein, L.W. Argenbright, L.G. Letts

Publikováno v: Journal of leukocyte biology. 49(3)

Increasing evidence indicates that leukocyte-endothelium adhesion is mediated, in part, by the CD11/CD18 family of heterodimeric glycoproteins expressed on the leukocyte plasma membrane and by intercellular adhesion molecule-1 (ICAM-1) which is expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2130e1bd324730ccdfaaa59e65ecf59
https://pubmed.ncbi.nlm.nih.gov/1671788

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L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor

Publikováno v: Canadian Journal of Physiology and Pharmacology. 65:2441-2448

L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol) was a potent inhibitor of leukotriene biosynthesis in intact rat and human leukocytes and CXBG mastocytoma cells (IC50 values, 18–240 nM) and of crude human leukocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e9ad37bfe37ad289156d26d0e2c814
https://doi.org/10.1139/y87-387

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Actions of synthetic leukotrienes on platelets and blood vessels in the anesthetised pig: the release of a platelet derived vasodilator

Autor: Maria Cirino, L.G. Letts, Joshua Rokach, B. Fitzsimonns, Anthony W. Ford-Hutchinson, P. Yusko

Publikováno v: Prostaglandins. 29:1049-1062

The actions of leukotrienes (LT's) C4, D4, E4 and F4 have been investigated in the perfused hind-limb of the anesthetized pig. In the blood perfused hind limb LTC4, D4 and E4 increased the perfusion pressure in a dose-dependent fashion whereas LTF4 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd3913f8246299738a5b5938b2b3233
https://doi.org/10.1016/0090-6980(85)90228-x

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The selectivity of β-adrenoceptor antagonists on isoprenaline-induced changes in heart rate, blood pressure, soleus muscle contractility and airways function in anaesthetized cats

Autor: Diana M. Temple, L.R. Williams, L.G. Letts, D.P. Richardson

Publikováno v: British Journal of Pharmacology. 80:323-334

The beta-adrenoceptor antagonist of propranolol, metoprolol, atenolol and butoxamine in anaesthetized cats has been measured and compared with the activity of four synthetic phenylethanolamine derivatives. The effects of isoprenaline on four paramete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036d4f5d835e2d0390481238e4e9aeda
https://doi.org/10.1111/j.1476-5381.1983.tb10037.x

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Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs

Autor: Stella Charleson, L.G. Letts, A. Lord

Publikováno v: Prostaglandins. 29:651-660

Radioimmunoassay and bioassay techniques have been used to investigate the ability of leukotriene (LT)F4 to release products of arachidonic acid metabolism from guinea pig isolated lungs perfused via the pulmonary artery. Also, the abilities of LTC4,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5656f370fbaa47323365133931e388a5
https://doi.org/10.1016/0090-6980(85)90088-7

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The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts

Autor: Priscilla J. Piper, L.G. Letts

Publikováno v: British journal of pharmacology. 76(1)

1 Infusions of leukotrienes C4 (LTC4) and LTD4 (5 min; 4 X 10-10-2 X 10-8 M) produced dose-dependent decreases in coronary flow in Langendorff preparations of guinea-pig isolated heats. 2 LTC 4 was more active than LTD4 and produced greater reduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f132a543adbbc3d3ac1ce92a0bf2fd6f
https://pubmed.ncbi.nlm.nih.gov/6896291

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Biliary and urinary excretion of peptide leukotrienes in the domestic pig

Autor: L.G. Letts, Joshua Rokach, A. Foster, Maria Cirino, D. Ezra

Publikováno v: Prostaglandins. 33(5)

The metabolism of leukotriene (LT)C4 and its major routes of elimination in vivo have been studied in four anesthetized domestic pigs administered intravenous [3H]-LTC4 (0.5 μCi/kg). The kinetic profile of LTC4 in the blood was followed for 60 min a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178fb5fc309baf23bf42b3c61a096d7d
https://pubmed.ncbi.nlm.nih.gov/3588975

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