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pro vyhledávání: '"L.E. Robson"'
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Publikováno v:
Journal of pharmacological methods. 23(4)
In homogenates of guinea-pig brain minus cerebellum, the delta-binding of 1.5 nM [3H]-[D-Pen2,D-Pen5]enkephalin is little affected by the type and concentration of the three buffers, Tris-HCl, HEPES-KOH, or TES-KOH (10-75 mM). However, the mu-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c31f35a6cbf6343716c1d192506b52
https://pubmed.ncbi.nlm.nih.gov/2164621
https://pubmed.ncbi.nlm.nih.gov/2164621
Publikováno v:
Journal of Neurochemistry. 45:1034-1042
Following incubation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25 degrees C and at 0 degrees C. Bestatin and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad81a6239cec15da96b2efc8f84cebf
https://doi.org/10.1111/j.1471-4159.1985.tb05520.x
https://doi.org/10.1111/j.1471-4159.1985.tb05520.x
Publikováno v:
Developmental Brain Research. 31:53-58
With selective labelling techniques and analysis of saturation curves it is shown that in rat brain the concentrations of μ-, δ- and χ-binding sites increase differentially during postnatal development. There are no changes in the binding affiniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f460f208a324ec07064fc97cf80378
https://doi.org/10.1016/0165-3806(87)90082-4
https://doi.org/10.1016/0165-3806(87)90082-4
Publikováno v:
Developmental Brain Research. 23:306-309
By selective labelling techniques together with analysis of saturation curves it is shown that the concentrations of the mu-, delta- and chi-binding sites increase during postnatal development particularly in the first few weeks after birth. There ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3a382d1cefbf04bb2f93ca5119721e
https://doi.org/10.1016/0165-3806(85)90056-2
https://doi.org/10.1016/0165-3806(85)90056-2
Autor:
Hans W. Kosterlitz, L.E. Robson, Paola Petrillo, Antonio La Regina, M. Sbacchi, Alessandra Tavani
Publikováno v:
European Journal of Pharmacology. 166:213-217
The highest maximum binding capacities at the μ-sites of rabbit brain are in the striatum, with intermediate levels in the diencephalon, mesencephalon, cerebellum and cortex and low level in the pons-medulla and hippocampus. For the δ-site the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef3384aec5b6c3824cd2d5f38443dbb
https://doi.org/10.1016/0014-2999(89)90061-7
https://doi.org/10.1016/0014-2999(89)90061-7
Publikováno v:
British Journal of Pharmacology. 85:665-673
The acute effects of beta-funaltrexamine and the effects of pre-incubation with this compound were examined in five in vitro assay tissues and in selective binding assays in homogenates of guinea-pig brain and myenteric plexus. In competitive displac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ad06266debb148de9f51e42a6417b3
https://doi.org/10.1111/j.1476-5381.1985.tb10562.x
https://doi.org/10.1111/j.1476-5381.1985.tb10562.x
Publikováno v:
Neuroscience. 12:621-627
(-)-[3H]Bremazocine interacts almost equally well with the mu-, delta- and kappa-types of opioid binding sites. In homogenates of guinea-pig cerebellum, it was bound with high affinity (KD = 0.046 nM) and the maximum binding capacity was 7.04 pmol/g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b58fea6d5e4c8ceaedddeab3b1cd35
https://doi.org/10.1016/0306-4522(84)90077-0
https://doi.org/10.1016/0306-4522(84)90077-0
Autor:
A.T. McKnight, L.E. Robson, S J Paterson, Alistair D. Corbett, Maureen G. C. Gillan, H.W. Kosterlitz
Publikováno v:
Regulatory Peptides. 10:1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160e9f31ce52cbb092fe3052d4dcea91
https://doi.org/10.1016/0167-0115(85)90209-5
https://doi.org/10.1016/0167-0115(85)90209-5
Publikováno v:
British Journal of Pharmacology. 66:601-608
1 Isolated ilea from guinea-pigs implanted with morphine pellets were stimulated coaxially, either with or without morphine present in the bath fluid, and the longitudinal contractions recorded. 2 In the absence of morphine the inhibitory effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d9fe77c30d578151486ddb5ab02da6
https://doi.org/10.1111/j.1476-5381.1979.tb13700.x
https://doi.org/10.1111/j.1476-5381.1979.tb13700.x