Zobrazeno 1 - 10
of 14
pro vyhledávání: '"L.B. Lallos"'
Autor:
Thierry Convard, L.B. Lallos, Florence Bonnaterre, Valérie Bidau, Houcine Rahali, David Standring, Virginie Roques, Francois-Rene Alexandre, Maria Seifer, Anna-Giulia Loi, Damien Gloux, Christophe Claude Parsy, Elodie Rosinovsky, Dominique Chaves, Catherine Caillet, Frederic Leroy, Guillaume Brandt, Dominique Louis Nestor Ghislain Surleraux, Sylvie Cappelle, Yann Griffon, Simon Savin, Musiu Chiara, Laure Moulat, Michel Liuzzi, Michel Derock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5427-5436
Exploration of the P2 region by mimicking the proline motif found in BILN2061 resulted in the discovery of two series of potent HCV NS3/4A protease inhibitors. X-ray crystal structure of the ligand in contact with the NS3/4A protein and modulation of
Autor:
Yann Griffon, Michel Derock, Damien Gloux, Francois-Rene Alexandre, Maria Seifer, Chiara Musiu, Christophe Claude Parsy, Houcine Rahali, Dominique Louis Nestor Ghislain Surleraux, Anna-Giulia Loi, Sylvie Cappelle, Frederic Leroy, Thierry Convard, Guillaume Brandt, Dominique Chaves, L.B. Lallos, Virginie Roques, David Standring, Laure Moulat, Michel Liuzzi, Catherine Caillet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4444-4449
Structural homology between thrombin inhibitors and the early tetrapeptide HCV protease inhibitor led to the bioisosteric replacement of the P2 proline by a 2,4-disubstituted azetidine within the macrocyclic β-strand mimic. Molecular modeling guided
Autor:
Maria Seifer, J. Gillum, Ilaria Serra, L.B. Lallos, David Standring, M. La Colla, Claire Pierra, J. Mccarville, John P. Bilello, C. Chapron
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4431-4442
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a clinically validated target for drugs designed to treat chronic HCV infection. This study evaluated the in vitro activity, selectivity, and resistance profile of a novel anti-HCV compou
Autor:
Dominique Louis Nestor Ghislain Surleraux, Yann Griffon, Christophe Claude Parsy, David Standring, Dominique Chaves, Houcine Rahali, Frederic Leroy, Chiara Musiu, Anna-Giulia Loi, L.B. Lallos, Catherine Caillet, Francois-Rene Alexandre, Maria Seifer, Michel Liuzzi, Damien Gloux, Laure Moulat, Thierry Convard, Michel Derock, Guillaume Brandt, Virginie Roques
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(18)
We disclose here the synthesis of a series of macrocyclic HCV protease inhibitors, where the homoserine linked together the quinoline P2' motif and the macrocyclic moiety. These compounds exhibit potent inhibitory activity against HCV NS3/4A protease
Publikováno v:
AIDS Research and Human Retroviruses. 15:895-897
Both HIV-1 primary isolates and laboratory strains incorporate cell-derived molecules into their envelopes depending on the host cell in which they are grown. This incorporation is not random and, specifically, HIV-1 has been shown to select against
Autor:
M. LaColla, Christophe Claude Parsy, M.A. Soubasakos, D.N. Standring, A. Bonin, L. Hubbard, Ilaria Serra, Dominique Louis Nestor Ghislain Surleraux, B. Li, L.B. Lallos, M. Liuzzi, J. Gillum, J. Mccarville, Maria Seifer, J.P. Bilello, J. Jakubik
Publikováno v:
Journal of Hepatology. 52:S298-S299
Autor:
Ilaria Serra, M.A. Soubasakos, D.N. Standring, M. LaColla, L.B. Lallos, J.P. Bilello, A. Bonin
Publikováno v:
Journal of Hepatology. 52:S299
Autor:
M. Liuzzi, S.S. Good, J. Gillum, J. Selden, J. Mc Carville, Dominique Louis Nestor Ghislain Surleraux, D.N. Standring, Maria Seifer, J.P. Bilello, Christophe Claude Parsy, M.A. Soubasakos, L.B. Lallos, M. Larsson, M. La Colla
Publikováno v:
Journal of Hepatology. 50:S132
Autor:
Erika Cretton-Scott, D.N. Standring, L. Licklider, M. La Colla, G. Gosselin, E. Hildebrand, M. Liuzzi, C. Pierra, Suzanne Peyrottes, J. Mccarville, Maria Seifer, Dominique Louis Nestor Ghislain Surleraux, Eric Badaroux, M. Camire, M. Larsson, C. Perigaud, L.B. Lallos, J.P. Bilello
Publikováno v:
Journal of Hepatology. 48:S220
Autor:
Francois-Rene Alexandre, M. La Colla, Christophe Claude Parsy, A.-G. Loi, B. Poddesu, Thierry Convard, Dominique Louis Nestor Ghislain Surleraux, M. Derock, M. Liuzzi, Laura Vargiu, T. Marceddu, F. Leroy, L.B. Lallos, C. Musiu, D.N. Standring
Publikováno v:
Journal of Hepatology. 48:S10