Výsledky vyhledávání

Early spreading events of fibroblasts on microgrooved substrates

Autor: L.A. Ginsel, John A. Jansen, X. F. Walboomers

Publikováno v: Journal of Biomedical Materials Research, 51, 529-534
Journal of Biomedical Materials Research, 51, 3, pp. 529-534

We investigated the "contact guidance" phenomenon, shortly after cell attachment. For this purpose polystyrene substrates were produced, either smooth, or equipped with micogrooves (depth 0.5 micrometer, width 1-10 micrometer). On these substrates, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b4fe950673a5ac6406e17d8e70c230
https://hdl.handle.net/2066/162438

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Orientation of ECM protein deposition, fibroblast cytoskeleton, and attachment complex components on silicone microgrooved surfaces

Autor: E.T. den Braber, J.E. de Ruijter, L.A. Ginsel, John A. Jansen, A. F. von Recum

Publikováno v: Journal of Biomedical Materials Research. 40:291-300

The microfilaments and vinculin-containing attachment complexes of rat dermal fibroblasts (RDF) incubated on microtextured surfaces were investigated with confocal laser scanning microscopy (CLSM) and digital image analysis (DIA). In addition, deposi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7dd88058b329a9b96cf7b4c1743481d
https://doi.org/10.1002/(sici)1097-4636(199805)40:2<291::aid-jbm14>3.0.co

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Growth behavior of fibroblasts on microgrooved polystyrene

Autor: H.J.E. Croes, L.A. Ginsel, John A. Jansen, X. F. Walboomers

Publikováno v: Biomaterials, 19, pp. 1861-1868
Biomaterials, 19, 1861-1868

We investigated the contact guidance phenomenon of rat dermal fibroblasts (RDF) on microgrooved polystyrene substrates. Grooves were 1 microm deep, and between 1 and 10 microm wide. Light microscopy and digital image analysis (DIA) showed that RDF we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b136390f711b412759514af6479d28
https://hdl.handle.net/2066/265163

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Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment

Autor: Cornelis P. Hollenberg, J. Ouwendijk, Wilma Peters, L.A. Ginsel, Jack A.M. Fransen, Hassan Y. Naim, C.E.C. Moolenaar

Publikováno v: Journal of Clinical Investigation, 97, pp. 633-641
Journal of Clinical Investigation, 97, 633-641

Congenital sucrase-isomaltase deficiency is an example of a disease in which mutant phenotypes generate transport-incompetent molecules. Here, we analyze at the molecular level a phenotype of congenital sucrase-isomaltase deficiency in which sucrase-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43f082fc207965b78b1cb0fd774b73a
https://doi.org/10.1172/jci118459

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Ultrastructural immunogold labeling of lipid-laden enterocytes from patients with genetic malabsorption syndromes

Autor: Nicole Verthier, Jack A.M. Fransen, Lawrence P. Aggerbeck, Gérard Feldmann, Marie-Elisabeth Samson-Bouma, L.A. Ginsel

Publikováno v: Biology of the Cell. 87:189-196

Intestinal biopsies from patients having genetic disorders of lipoprotein assembly and secretion, such as abetalipoproteinemia (ABL) or Anderson's disease (AD), contain large amounts of lipids which are accumulated in the enterocytes. Determination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e7d3dd0556f2f6cc7d70ec865fd5cb8
https://doi.org/10.1111/j.1768-322x.1996.tb00980.x

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Quantitative analysis of fibroblast morphology on microgrooved surfaces with various groove and ridge dimensions

Autor: A. F. von Recum, John A. Jansen, L.A. Ginsel, E.T. den Braber, J.E. de Ruijter

Publikováno v: Biomaterials, 17, pp. 2037-2044
Biomaterials, 17, 2037-2044
Biomaterials, 17, 21, pp. 2037-2044

Fibroblasts have been shown to respond to substratum surface roughness. The change in cell size, shape and orientation of rat dermal fibroblasts (RDF) was therefore studied using smooth and microtextured silicone rubber substrata. The microtextured s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926d98b7c79138dc2626e592b8b85883
https://hdl.handle.net/2066/22838

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Titin aggregates associated with intermediate filaments align along stress fiber-like structures during human skeletal muscle cell differentiation

Autor: P. F. M. Van Der Ven, Paul H.K. Jap, L.A. Ginsel, G. Schaart, F. C. S. Ramaekers, H.J.E. Croes

Publikováno v: Journal of Cell Science. 106:749-759

Differentiating human skeletal muscle cell cultures were used to study the association of titin with other sarcomeric and cytoskeletal proteins during myofibrillogenesis. Several developmental stages of these cultures were double stained with antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350c8b7aedc213f000f3459b59415a64
https://doi.org/10.1242/jcs.106.3.749

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Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation

Autor: Arthur J. Verhoeven, J.J.M. Onderwater, L.A. Ginsel, Dirk Roos, C. E. Van Der Schoot, Taco W. Kuijpers, Anton T.J. Tool

Publikováno v: Blood. 78:1105-1111

Neutrophil research relies largely on studies with highly purified cells. Yet the isolation procedures induce changes in surface expression of several proteins. We used a large panel of monoclonal antibodies (MoAbs) to characterize in detail the phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1feb570d591419558248e5a1cf58682
https://doi.org/10.1182/blood.v78.4.1105.bloodjournal7841105

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Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes

Autor: Michael J. Lentze, Hans-Peter Hauri, Erwin E. Sterchi, H Y Naim, J. Bond, Jack A.M. Fransen, P. R. Mills, L.A. Ginsel

Publikováno v: Journal of Clinical Investigation. 86:1329-1337

Enzymatic activity, biosynthesis, and maturation of lactasephlorizin hydrolase (LPH) were investigated in adult volunteers with suspected lactose intolerance. Mean LPH activity in jejunal biopsy homogenates of these individuals was 31% compared to LP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4baf6abe6616d977375b3ffd6e2d8a
https://doi.org/10.1172/jci114842

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The small GTPases Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus

Autor: L.A. Ginsel, J.A.J.M. van den Hurk, F.J.M. Opdam, R.A. van de Vorstenbosch, H.J.E. Croes, Arnaud Echard, Jack A.M. Fransen, B. Goud

Publikováno v: Journal of Cell Science, 113, 2725-2735
Journal of Cell Science, 113, pp. 2725-2735
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Members of the Rab subfamily of small GTPases play an important role in the regulation of intracellular transport routes. Rab6A has been shown to be a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6102ad94374b66085a5fe19512e10664
http://hdl.handle.net/2066/185923

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