Zobrazeno 1 - 10
of 1 798
pro vyhledávání: '"L.-H. Huang"'
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do no
Externí odkaz:
https://doaj.org/article/27ffa265831142f6b7a441d2795d3526
Autor:
Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge r
Externí odkaz:
https://doaj.org/article/7a7224d6282a486ca9a2c8a589c4d075
Autor:
Federico Bertagna, Shiraz Ahmad, Rebecca Lewis, S. Ravi P. Silva, Johnjoe McFadden, Christopher L.-H. Huang, Hugh R. Matthews, Kamalan Jeevaratnam
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It demonstrate
Externí odkaz:
https://doaj.org/article/94e8beade09943b6a18bc501602977b3
Autor:
Joshua A. Morris, Oliver J. Bardsley, Samantha C. Salvage, Antony P. Jackson, Hugh R. Matthews, Christopher L-H. Huang
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Introduction: In addition to gap junction conduction, recent reports implicate possible ephaptic coupling contributions to action potential (AP) propagation between successive adjacent cardiomyocytes. Here, AP generation in an active cell, withdraws
Externí odkaz:
https://doaj.org/article/c07da66d15954f158d1d4733b176bd69
Autor:
Ying H. Huang, MMath, PhD, Jane V. Lyle, BSc, Anisa Shahira Ab Razak, BA, Manasi Nandi, BSc, PhD, Celia M. Marr, BVMS, MVM, PhD, DEIM, DipECEIM, FRCVS, Christopher L.-H. Huang, BA, BM, BCh, PhD, DM, MD, DSc, ScD, FRSB, Philip J. Aston, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, FRCVS
Publikováno v:
Cardiovascular Digital Health Journal, Vol 3, Iss 2, Pp 96-106 (2022)
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia in both human and equine populations. It is associated with adverse outcomes in humans and decreased athletic performance in both populations. Paroxysmal atrial fibrillation (PAF) pr
Externí odkaz:
https://doaj.org/article/8f50d0217e2343dcae7574277cb04b72
Autor:
Ting-Yung Kuo, Chao-Cheng Huang, Shyh-Jou Shieh, Yu-Bin Wang, Ming-Jen Lin, Ming-Che Wu, Lynn L. H. Huang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract An appropriate animal wound model is urgently needed to assess wound dressings, cell therapies, and pharmaceutical agents. Minipig was selected owing to similarities with humans in body size, weight, and physiological status. Different wound
Externí odkaz:
https://doaj.org/article/55eae88f10924557852d06384951211f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract A finite element analysis modelled diffusional generation of steady-state Ca2+ microdomains within skeletal muscle transverse (T)-tubular-sarcoplasmic reticular (SR) junctions, sites of ryanodine receptor (RyR)-mediated SR Ca2+ release. It u
Externí odkaz:
https://doaj.org/article/48d31e6e90444a8f8b311e1a53fd6e0a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (I Na) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffei
Externí odkaz:
https://doaj.org/article/6f44123619ea4ddabbb1ac1ad20bffe5
Autor:
Esther Bonet-Luz, MMath, PhD, Jane V. Lyle, BSc, Christopher L.-H. Huang, MA, BMBCh, DM, DSc, PhD, MD, ScD, Yanmin Zhang, MD, PhD, Manasi Nandi, BSc, PhD, Kamalan Jeevaratnam, DAHP, DVM, MMedSC, PhD, MRCVS, Philip J. Aston, BSc, PhD
Publikováno v:
Heart Rhythm O2, Vol 1, Iss 5, Pp 368-375 (2020)
Background: Life-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detecti
Externí odkaz:
https://doaj.org/article/fce511eb313c4fd4a215e909aeff36ca
Autor:
L. L. Yang, B. Jiang, S. H. Chen, H. Y. Liu, T. T. Chen, L. H. Huang, M. Yang, J. Ding, J. J. He, J. J. Li, B. Yu
Publikováno v:
Skin Health and Disease, Vol 2, Iss 1, Pp n/a-n/a (2022)
Abstract Background Prurigo nodularis (PN) is a highly pruritic, chronic dermatosis and difficult to treat. PN lesions are characterized by existence of many hyperkeratotic, erosive papules and nodules. However, the pathogenesis of PN still remains u
Externí odkaz:
https://doaj.org/article/81ab0631fee2467ea0d457b997059b67