Zobrazeno 1 - 10
of 191
pro vyhledávání: '"L. den Engelse"'
Autor:
Jan H. Schornagel, L. Den Engelse, A.M.J. Fichtinger-Schepman, C. Michael, F.A. Blommaert, H.C.M. van Dijk-Knijnenburg
Publikováno v:
Cancer Chemotherapy and Pharmacology, 38, 273-280
The formation and persistence of platinum-DNA adducts were studied with immuno(cyto)chemical methods in male and female Sprague-Dawley rats treated with a single i.p. dose of carboplatin. Linear dose-effect curves were observed for kidney and liver w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6120f08b28147276b1e9a790b8802aa2
https://doi.org/10.1007/s002800050482
https://doi.org/10.1007/s002800050482
Autor:
E. Scherer, H.H.K. Winterwerp, Christopher P. Wild, J. Van Benthem, E. Vermeulen, L. Den Engelse
Publikováno v:
Carcinogenesis. 13:2101-2105
The distribution and accumulation of O6-methylguanine (O6-meGua) and 7-methylguanine (7-meGua) was investigated immunocytochemically in target and non-target tissues of rats injected twice weekly with 0.5 mg N-nitroso-N-methylbenzylamine (NMBzA)/kg f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4a5a6ba1d1b5e10149e1f5b860b2cc
https://doi.org/10.1093/carcin/13.11.2101
https://doi.org/10.1093/carcin/13.11.2101
Autor:
O. van Tellingen, Adrian C. Begg, L. Den Engelse, Terheggen Pm, E. L. M. Lempers, B.G.J. Floot
Publikováno v:
Cancer Chemotherapy and Pharmacology. 28:185-191
Cytotoxic effects ofcis-diamminedichloroplatinum-(II) (cis-DDP) are thought to be mediated by binding to DNA. Studies on binding ofcis-DDP to cellular DNA rely heavily on the availability of specific antibodies. We therefore, raised and characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f59b4dedb3dc72da5ca0bf2c65fda7
https://doi.org/10.1007/bf00685507
https://doi.org/10.1007/bf00685507
Publikováno v:
Carcinogenesis. 12:1831-1837
The formation and short-term persistence of O6-methylguanine (O6-meGua) and 7-methylguanine (7-meGua) in individual cells of various target and non-target tissues for tumor induction in rats were examined after a single dose of N-nitroso-N-methylbenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73533573a56c6c4abe10dada2d564b15
https://doi.org/10.1093/carcin/12.10.1831
https://doi.org/10.1093/carcin/12.10.1831
Publikováno v:
Carcinogenesis. 12:427-433
The formation and stability of benzo[a]pyrene DNA adducts were studied in tissues of BALB/c mice exposed to benzo[a]pyrene (B[a]P). The DNA adducts were visualized with an immunocytochemical peroxidase staining technique using an antiserum specific f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c383ce2d705efffbce285f03a7f2c4a8
https://doi.org/10.1093/carcin/12.3.427
https://doi.org/10.1093/carcin/12.3.427
Publikováno v:
British Journal of Cancer
Binding of the cytostatic drug carboplatin to DNA was studied in solution, in RIF-1 and CHO cell lines and in human buccal cells after in vitro or in situ drug exposure. Results were compared with DNA adduction by cisplatin. The rate of binding in so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29db4c0ba7f0af9a11b78941fbf67ec
http://europepmc.org/articles/PMC1971771
http://europepmc.org/articles/PMC1971771
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 116:134-140
Adducts between aflatoxin B1 and G1 and DNA have been visualised and quantified in various rat tissues by a sensitive immunocytochemical approach. The quantitative validity of this assay has been examined by comparison with experiments using radioact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b07eaae8d6fec559a73c82f89ed28b
https://doi.org/10.1007/bf01612667
https://doi.org/10.1007/bf01612667
Autor:
H.C.M. van Dijk-Knijnenburg, Robert A. Baan, L. Den Engelse, A.M.J. Fichtinger-Schepman, F. Berends, B.G.J. Floot, Jan H. Schornagel, F.A. Blommaert
Publikováno v:
Chemico-Biological Interactions, 108, 209-225
We have studied the formation and repair of cisplatin-DNA adducts in wild-type mouse leukemia L1210/0 cells and in the sublines L1210/2 and L1210/5, which differ in cisplatin sensitivity. In a colony-formation assay these sublines were 9- and 22-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843567ed6a98a3e960201245a38779db
https://pubmed.ncbi.nlm.nih.gov/9528691
https://pubmed.ncbi.nlm.nih.gov/9528691
Autor:
L. Den Engelse, Robert A. Baan, A.M.J. Fichtinger-Schepman, F.A. Blommaert, H.C.M. van Dijk-Knijnenburg, Fransje J. Dijt, F. Berends
Publikováno v:
Biochemistry. 34(26)
We have studied the formation of adducts upon carboplatin treatment of isolated DNA and in cells. The major adduct formed in vitro, determined with atomic absorption spectroscopy and enzyme-linked immunosorbent assay, was the intrastrand cross-link c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950ef9353e15802aad2fa76d517a54f0
https://pubmed.ncbi.nlm.nih.gov/7599137
https://pubmed.ncbi.nlm.nih.gov/7599137
Publikováno v:
Carcinogenesis. 16(7)
Within the group of DNA alkylation products, phosphotriesters (PTE) are among the most stable lesions. Hence, alkyl PTE are attractive biomarkers for DNA alkylation monitoring purposes. We have developed a 32P-postlabelling method for the analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc712d7bb704515dfea0c1b4fc6a3a82
https://pubmed.ncbi.nlm.nih.gov/7614687
https://pubmed.ncbi.nlm.nih.gov/7614687