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SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy
Autor:
Hilal Özdağ, N. Lale Şatiroğlu-Tufan, Elif İnce, Recep Bindak, Mehmet Ertem, Ozge Cumaogullari, İrem Eldem, L. Zümrüt Uysal, Talia Ileri, Beyza Doğanay Erdoğan, Duygu Yavuz
Publikováno v:
Journal of pediatric hematology/oncology. 40(5)
BACKGROUND Therapy discontinuations and toxicities occur because of significant interindividual variations in 6-mercaptopurine (6-MP) and methotrexate (MTX) response during maintenance therapy of childhood acute lymphoblastic leukemia (ALL). 6-MP/MTX