Zobrazeno 1 - 10
of 15
pro vyhledávání: '"L. Wayne Tansey"'
Publikováno v:
Canadian Journal of Chemistry. 45:2963-2967
Some aromatic 1-aryl(and 1-aralkyl)-β-carbolines were prepared from their tetrahydro analogues by dehydrogenation over palladium on charcoal either in a Parr bomb or in refluxing toluene. The bomb reaction appears to be a better procedure for the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728f0328cb263bc32db99ccfe6020f64
https://doi.org/10.1139/v67-478
https://doi.org/10.1139/v67-478
Autor:
Juhana J. Idänpään-Heikkilä, William M. McIsaac, G. Edward Fritchie, Beng T. Ho, Vicente Estevez, L. Wayne Tansey
Publikováno v:
Biochemical Pharmacology. 20:1313-1319
The distribution and metabolic fate of [3H]harmaline-HCl were studied in rats. Thirty min after subcutaneous injection, high radioactivity was found in the small intestine, liver, adrenals, kidneys and lungs. A rapid turnover and elimination was evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2345b8e7ef7a08dcb1f046494ced331
https://doi.org/10.1016/0006-2952(71)90363-7
https://doi.org/10.1016/0006-2952(71)90363-7
Publikováno v:
Journal of Pharmaceutical Sciences. 58:563-566
During previous studies on the inhibition of hydroxyindole-O-methyltransferase, several N-acyltryptamines have been found to be good inhibitors of this enzyme. Substitution of the benzyl or phenyl moiety of N-phenylacetyltryptamine or N-benzoyltrypta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5721ddf8e81c1f93495291a3c9e770
https://doi.org/10.1002/jps.2600580508
https://doi.org/10.1002/jps.2600580508
Autor:
Juhana E. Idänpään-Heikkilä, William M. McIsaac, Beng T. Ho, G. Edward Fritchie, L. Wayne Tansey
Publikováno v:
Brain Research. 22:397-401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b8c96e224e8e17e9ae87e019146ec6
https://doi.org/10.1016/0006-8993(70)90481-6
https://doi.org/10.1016/0006-8993(70)90481-6
Publikováno v:
Journal of Pharmaceutical Sciences. 58:998-1001
Several analogs of tetrahydro-β-carboline (I) and 9-methyltetrahydro-β-carboline (VII) with substituents on C-6 or C-8 were synthesized. Methylation of the N-9 position of a tetrahydro β-carboline is generally achieved in the presence of a base. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1854eea6a456aea0ceccd4c7f16a3
https://doi.org/10.1002/jps.2600580821
https://doi.org/10.1002/jps.2600580821
Autor:
Rong An, William M. McIsaac, L. Wayne Tansey, K.E. Walker, B. T. Ho, Leo F. Englert, Michael Noel
Publikováno v:
Journal of Medicinal Chemistry. 13:26-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d9cd204f00105368f7239e68ede55e
https://doi.org/10.1021/jm00295a007
https://doi.org/10.1021/jm00295a007
Publikováno v:
Journal of Pharmaceutical Sciences. 58:219-221
A series of 9-alkyl aromatic-β-carbolines was synthesized and evaluated as inhibitors of mitrochondrial monoamine oxidase. The possible existence of a hydrophobic or hydrophilic region on the enzyme was explored. Substitution of an electron-withdraw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57777ce8d01e1e83ccd5f471847ed5d
https://doi.org/10.1002/jps.2600580217
https://doi.org/10.1002/jps.2600580217
Publikováno v:
Journal of pharmaceutical sciences. 59(10)
A number of 6(or 8)-substituted aromatic β-carbolines were synthesized, and their inhibitory activities toward monoamine oxidase were compared with their tetrahydro congeners. A considerable difference in the effects of 6(or 8)-substitution on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cbafa3b203673070ed8e4167e18b4d
https://pubmed.ncbi.nlm.nih.gov/5471952
https://pubmed.ncbi.nlm.nih.gov/5471952
Publikováno v:
Journal of pharmaceutical sciences. 57(11)
Several N-acyltryptamines were found to inhibit hydroxyindole-O-methyltransferase. Of these inhibitors the most active was N-phenylacetyltryptamine, having an affinity to the enzyme six times greater than the substrate N-acetylserotonin. These studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e500eee6043975929716ff5b5bc3075
https://pubmed.ncbi.nlm.nih.gov/5725938
https://pubmed.ncbi.nlm.nih.gov/5725938
Autor:
Beng T. Ho, L. Wayne Tansey, George E. Fritchie, William M. McIsaac, Juhana E. Idänpään-Heikkilä
Publikováno v:
Science (New York, N.Y.). 164(3883)
The hallucinogen 2,5-dimethoxy,-4-methylamphetamine, also known as STP, accumulates in specfic areas of cat brains. The unchanged compound was detected in the brain for at least 6 hours, whereas its behavioral effects lasted for about 4 hourS. The co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd86371f1d62124d0a8a443326eacda2
https://pubmed.ncbi.nlm.nih.gov/5769766
https://pubmed.ncbi.nlm.nih.gov/5769766