Zobrazeno 1 - 8
of 8
pro vyhledávání: '"L. W. Woo"'
Autor:
Michael J. Reed, Yaikat Ho, James J. Robinson, Nigel Vicker, Barry V. L. Potter, Lawrence L. W. Woo, Atul Purohit
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:863-865
We describe the docking of selected steroidal and non-steroidal estrone sulphatase inhibitors, including the Phase I clinical trial candidate 667COUMATE (6), into the active site of human carbonic anhydrase II (hCA II). The docking scores are compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237375f10f22391a3240621bbe1af3a2
https://doi.org/10.1016/s0960-894x(03)00009-x
https://doi.org/10.1016/s0960-894x(03)00009-x
Autor:
Paul A. Foster, Simon P. Newman, Surindaer. K. Chander, Roma Jhalli, Chloe Stengel, Atul Purohit, Barry V. L. Potter, Lawrence L. W. Woo, Michael J. Reed
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 12(18)
Purpose: Steroid sulfatase (STS) inhibitors that can decrease or prevent the biosynthesis of estrogenic steroids via the sulfatase route may play an important role in the treatment of breast cancer. We compare the in vivo efficacy of two potent STS i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99fbdcba6304a6f4df8bc74b0a4a9a7
https://pubmed.ncbi.nlm.nih.gov/17000691
https://pubmed.ncbi.nlm.nih.gov/17000691
Publikováno v:
Cancer research. 60(13)
The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treatment of postmenopausal women with breast cancer. A series of tricyclic coumarin sulfamates were synthesized, and their inhibitory properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32bd8fc22818a37bc548959ac78b8a5d
https://pubmed.ncbi.nlm.nih.gov/10910045
https://pubmed.ncbi.nlm.nih.gov/10910045
Publikováno v:
Cancer research. 56(21)
Steroid sulfatase regulates the formation of estrone from estrone sulfate (E1S) and dehydroepiandrosterone (DHA) from DHA sulfate. DHA can be converted to androstenediol, a steroid with potent estrogenic properties, and inhibition of steroid sulfatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e84ae979f8e291f7cb715df00834431d
https://pubmed.ncbi.nlm.nih.gov/8895749
https://pubmed.ncbi.nlm.nih.gov/8895749
Autor:
Michael J. Reed, S. J. Stanway, Richard H. Wilson, Barry V. L. Potter, Atul Purohit, R. C. Coombes, L. W. Woo, Patrick Delavault, N. Dobbs, Frank Z. Stanczyk
Publikováno v:
Journal of Clinical Oncology. 24:580-580
580 Background: Steroid sulfatase (STS) inhibitors, such as STX64, were developed to block the sulfatase pathway of estrogen formation in postmenopausal (PM) women with ER+ breast cancer. They act by blocking the formation of estrone from estrone sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::493629f958983e2321c39fbc26bfbcf5
https://doi.org/10.1200/jco.2006.24.18_suppl.580
https://doi.org/10.1200/jco.2006.24.18_suppl.580
Publikováno v:
Physical Review C. 29:794-804
The differential cross sections for elastic and inelastic scattering to the first excited (${2}^{+}$) states of 100 MeV protons from $^{46,48,50}\mathrm{Ti}$ were measured. The angular ranges covered were 9\ifmmode^\circ\else\textdegree\fi{} to 110\i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ae9c064587846323eebfdffb05f362
https://doi.org/10.1103/physrevc.29.794
https://doi.org/10.1103/physrevc.29.794
Publikováno v:
Physical Review Letters. 42:54-57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aab0e426ba03964e058b287abf8b312
https://doi.org/10.1103/physrevlett.42.54
https://doi.org/10.1103/physrevlett.42.54
Publikováno v:
Physical Review C. 39:1730-1735
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bbb170d1dbb08dd4b35d0f53b45067f
https://doi.org/10.1103/physrevc.39.1730
https://doi.org/10.1103/physrevc.39.1730